细胞内蛋白质降解的生理功能。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY Annual review of cell and developmental biology Pub Date : 2022-05-19 DOI:10.1146/annurev-cellbio-120420-091943
E. McShane, M. Selbach
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引用次数: 3

摘要

虽然细胞蛋白质最初被认为是稳定的,但过去几十年的研究已经坚定地证明,细胞内蛋白质降解是一个活跃且高度调节的过程:溶酶体、蛋白酶体和线粒体降解系统被鉴定并发现参与了数量惊人的生物功能。在这里,我们使用七个类别对细胞蛋白质降解的不同作用进行了全面概述:稳态、调节、质量控制、化学计量控制、蛋白质组重塑、免疫监测和基线周转。使用选定的例子,我们概述了蛋白质是如何降解的,以及为什么这在功能上是相关的。《细胞与发育生物学年度评论》第38卷预计最终在线出版日期为2022年10月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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Physiological Functions of Intracellular Protein Degradation.
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process: Lysosomal, proteasomal, and mitochondrial degradation systems were identified and found to be involved in a staggering number of biological functions. Here, we provide a global overview of the diverse roles of cellular protein degradation using seven categories: homeostasis, regulation, quality control, stoichiometry control, proteome remodeling, immune surveillance, and baseline turnover. Using selected examples, we outline how proteins are degraded and why this is functionally relevant. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 38 is October 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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