艾滋病毒和艾滋病毒/结核病合并感染:俄罗斯西北联邦区地区的聚集分布

Z. Zagdyn, O. B. Nechaeva, S. Sterlikov, T. P. Vasilyeva, O. Alexandrova
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引用次数: 0

摘要

介绍。影响结核病负担的主要因素之一是艾滋病毒进展,反过来,艾滋病患者主要死于结核病。该研究的目的是确定2007年至2018年间俄罗斯西北西北地区艾滋病毒、艾滋病毒/结核病合并感染的高风险地区。材料和方法。采用k -均值法对西北西北地区10个地区的HIV、HIV/TB发病率、流行率、死亡率以及异性恋HIV传播途径聚类的比例进行统计。需求数据提取自2007年至2018年联邦统计观测的相关形式。由于研究期间没有HIV/TB合并感染病例,NAO被排除在聚类分析之外。为了全面了解艾滋病毒/结核病合并感染的趋势,还估计了结核病的发病率、流行率和死亡率,但未将其纳入聚类分析。在结核病病例显著减少的同时,大多数地区的艾滋病毒病例数据也有所增加,特别是在阿尔汉格尔斯克州,在分析期间艾滋病毒发病率上升了617.8%。与此同时,加里宁格勒州成为2007-2018年唯一一个艾滋病毒发病率(-21.5%)和死亡率(-65.6%)以及艾滋病毒/结核病发病率(-55.0%)下降的地区。异性恋HIV传播风险几乎在所有地区都很高,特别是在NAO州(100.0%)、普斯科夫州(89.2%)、诺夫哥罗德州(78.8%)。k -均值法检测到的艾滋病毒传播最高的是阿尔汉格尔斯克州(第一聚集群),最低的是加里宁格勒、列宁格勒、摩尔曼斯克州和圣彼得堡(第三聚集群)。其他艾滋病毒病例数据中等的地区形成第二聚类。艾滋病毒/结核病合并感染在阿尔汉格尔斯克州、普斯科夫州和诺夫哥罗德州(第一聚集性病例)传播最快,在加里宁格勒州、列宁格勒州和圣彼得堡(第三聚集性病例)传播最慢。其他地区HIV/TB合并感染传播率平均,形成第二中间群。随着结核病流行的显著改善,艾滋病毒和艾滋病毒/结核病合并感染在西北西北地区的传播被认为是不均衡的。在艾滋病毒病例高度集中的地区,艾滋病毒和艾滋病毒/结核病合并感染率下降。相反,在艾滋病毒积累较少的地区,艾滋病毒病例率以及艾滋病毒/结核病合并感染病例数据最高,这表明需要加强艾滋病毒传播较低地区PLWH的结核病措施。
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HIV and HIV/TB coinfection: cluster distribution of regions in the Northwestern Federal District of Russia
Introduction. One of the main factors affecting TB burden is HIV progression and, in turn, PLWH predominantly die of TB.The study purpose was to identify high risk regions of HIV, HIV/TB coinfection in NWFD of Russia between years of 2007 to 2018.Materials and methods. K-means method was applied to identify HIV, HIV/TB incidence, prevalence and mortality rates, as well as share of heterosexual HIV transmission route clusters in 10 regions of NWFD. The need data were extracted from relevant forms of federal statistical observation between 2007 to 2018. NAO was excluded from cluster analysis due to absence of HIV/TB coinfection cases in study period. For holistic understanding of HIV/TB coinfection trends, TB incidence, prevalence and mortality rates were estimated too without including them in cluster analysis.Results. Along with significant reduce in TB cases there was increase in HIV case data in most regions, especially in Arkhangelsk oblast where HIV incidence raised by 617.8% in period analyzed. Meanwhile Kaliningrad oblast became the only region where HIV incidence (–21.5%) and mortality (–65.6%), also HIV/TB incidence (–55.0%) is failed in 2007–2018. Heterosexual HIV transmission risk was high in almost all regions, especially in NAO (100.0%), Pskov (89.2%), Novgorod (78.8%) oblasts. K-means method detected the highest HIV spread in Arkhangelsk oblast (first cluster), lowest — in Kaliningrad, Leningrad, Murmansk oblasts and St. Petersburg (third cluster). Other regions with intermediate HIV case data formed second cluster. HIV/TB coinfection most rapidly spreads in Arkhangelsk, Pskov and Novgorod oblasts (first cluster), most slowly — in Kaliningrad, Leningrad oblasts and in St. Petersburg (third cluster). In other regions, spread of HIV/TB coinfection has average rate, forming second intermediate cluster.Conclusion. Along with significant improvement in TB epidemic, spread of HIV and HIV/TB coinfection in regions of NWFD considered as uneven. In regions with high concentration of HIV cases, HIV and HIV/TB coinfection rates are slowed down. Conversely, highest rates of HIV cases, as well as of HIV/TB coinfection case data, are observed in regions with low HIV accumulation, indicating the need to strengthen TB measures in PLWH in regions with a low spread of HIV. 
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来源期刊
HIV Infection and Immunosuppressive Disorders
HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases
CiteScore
0.70
自引率
0.00%
发文量
37
期刊介绍: In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.
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