Synthesis of Oxadiazole, Imidazole, Benzimidazole, Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage

To synthesize Oxadiazole, Imidazole, Benzimidazole, and Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage It is worthwhile to mention that Imidazoles, benzimidazoles, oxadiazoles, are analysed extensively mainly as per their ready availability, broad chemical reactivity, and wide spectrum of biochemical activities, like antimicrobial, anti-inflammatory, antitumor, anticonvulsant drugs, anti-tubercular medicines, and having anti-HIV effect etc. The Oxadiazole, Imidazole, Benzimidazole derivatives were synthesized via Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage. The characteristic drift of our interest towards these molecules prompted us to think about the structural modification of [1, 5]-benzodiazepine compound by incorporating on its 2-position imidazole, benzimidazole, oxadiazole, nuclei through an aminophenyl or phenoxyl bridge to synthesize these novel heterocyclic analogues of 1, 5-benzodiazepines. These derivatives have been analysed by various spectrophometric techniques like UV, IR, NMR, and MS. The synthesis of these compounds via the mentioned methods are unique as Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino is a totally new way of synthesis. The derivatives can be analysed for various properties in chemistry and pharmacology, as their parent compounds has many pharmacological properties. The synthesis of these types of compounds does provide a new hope to medicinal and pharmaceutical industries. Therefore further efforts should be taken into consideration for their synthesis and analysis of their medicinal properties.