2016年纳米比亚温得和克孕妇巨细胞病毒血清流行率

IF 0.4 Q4 OBSTETRICS & GYNECOLOGY South African Journal of Obstetrics and Gynaecology Pub Date : 2019-11-06 DOI:10.7196/SAJOG.1441
B. E. van der Colf, G. V. van Zyl, S. Mackenzie
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引用次数: 4

摘要

背景巨细胞病毒(CMV)在发展中国家的血清流行率很高。然而,孕妇的免疫力并不一定能保护她的婴儿免受先天性巨细胞病毒感染。目标。确定在公共产前诊所(纳米比亚温得和克中央医院)就诊的孕妇中CMV的血清流行率,随后确定垂直传播和先天性CMV感染的风险。方法。采集了344名孕妇(年龄在15-48岁之间)的血液样本和人口统计信息。使用自动化学发光测定法检测血清中的抗CMV IgG和IgM,并使用ELISA来评估特异性IgG亲和力。Fisher精确检验用于确定变量之间的关联。结果。研究人群中抗CMV IgG的血清流行率为100%,11名女性(3.2%)的抗CMV IgM结果呈阳性或灰色地带。所有病例的特异性IgG亲和力都很高。母体和胎龄均与IgM阳性或灰色地带结果呈正相关。产次与CMV-IgM血清流行率显著相关,在既往妊娠过一次的女性中观察到最高水平。结论。这是第一项调查纳米比亚CMV血清流行率的研究。尽管孕妇血清阳性率很高,但纳米比亚人口中的婴儿可能携带先天性巨细胞病毒感染的负担。这可能会导致长期残疾,尤其是感音神经性听力损失。需要进一步的研究来确定纳米比亚先天性巨细胞病毒的患病率。
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Seroprevalence of cytomegalovirus among pregnant women in Windhoek, Namibia, 2016
Background. Seroprevalence of cytomegalovirus (CMV) is high in developing countries. However, a pregnant woman’s immunity does not necessarily protect her baby against congenital CMV infection.  Objectives. To determine the seroprevalence of CMV among pregnant women attending a public antenatal clinic (Windhoek Central Hospital, Namibia) and subsequently determine the risk of vertical transmission and congenital CMV infection.  Methods. Blood samples and demographic information were collected from 344 pregnant women (age range 15 - 48 years). Serum was tested for anti-CMV IgG and IgM using an automated chemiluminescence assay, and an ELISA was used to assess specific IgG avidity. Fisher’s exact test was used to determine associations among variables.  Results. Seroprevalence of anti-CMV IgG was found to be 100% across the study population, with positive or grey-zone anti-CMV IgM results found in 11 women (3.2%). Specific IgG avidity was high in all cases. Neither maternal nor gestational age was positively associated with a positive or grey-zone IgM result. Parity was significantly associated with CMV IgM seroprevalence, with the highest level observed in women who had had one previous pregnancy.  Conclusion. This was the first study to investigate seroprevalence of CMV in Namibia. Despite the high seroprevalence among pregnant women, the burden of congenital CMV infection may b e carried by infants in the Namibian population. This may contribute to long-term disabilities, especially sensorineural hearing loss. Further studies are needed to determine the prevalence of congenital CMV in Namibia.
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来源期刊
South African Journal of Obstetrics and Gynaecology
South African Journal of Obstetrics and Gynaecology Medicine-Obstetrics and Gynecology
CiteScore
0.40
自引率
0.00%
发文量
5
审稿时长
15 weeks
期刊介绍: The SAJOG is a tri-annual, general specialist obstetrics and gynaecology journal that publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. The journal carries original research articles, editorials, clinical practice, personal opinion, South Africa health-related news, obituaries and general correspondence.
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