膝关节置换术后的血液回收:它们仍然有用吗?回顾性队列研究

I. Valbuena, E. Guasch, N. Brogly, R. Schiraldi, J. Díez, F. Gilsanz
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引用次数: 1

摘要

研究背景和目标:血液抢救(BS)对于实施患者血液管理的第二支柱以避免全膝关节置换术(TKA)后的贫血非常重要。我们的主要结果是评估BS在降低TKA中同种异体输血(ABT)率方面的有用性。材料和方法:对连续计划接受或不接受BS TKA的患者进行回顾性、观察性队列研究。记录人口统计学、合并症、手术和麻醉数据、实验室术前和术后结果、BS的排血和再输血量以及ABT的要求。采用了参数和非参数测试。p<0.05被认为是显著的。结果:纳入260名患者(每个队列130名)。术后出血量为713.1+445.4 ml。26.5%的患者接受了ABT。BS减少了13,1%(p=0.024)的输血,RR为1.65(CI 1085-2,52)]。术后出血的危险因素有:男性、心房颤动、术前抗血小板治疗和非骨水泥原发性TKA。ABT的危险因素:ASA>II,术前血红蛋白<13 g/dl,膝关节翻修,抗血小板治疗,手术时间较长。输血患者的血红蛋白值较低(p<0.001),中等LOS较长(+2.5天,p=0.026)。结论:在TKA中使用BS有利于减少同种异体输血和住院时间。对于TKA操作的血栓栓塞事件高危患者,BS仍然是氨甲环酸的有效、安全和廉价的替代品。
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Postoperative Blood Salvage after knee arthroplasty: are they still useful? A retrospective cohort study
Background and Goal of Study: Blood salvage (BS) is important to implement the second pillar of Patient Blood Management to avoid anaemia after total knee arthroplasty (TKA). Our primary outcome was to assess BS usefulness to decrease allogenic blood transfusion (ABT) rate in TKA. Materials and Methods: a retrospective, observational cohort study was conducted on consecutive patients scheduled for TKA with BS or not. Demographic, comorbidity, surgical and anesthetic data, laboratory pre and postoperative results, volume of blood drained, and reinfused from BS and the requirement of ABT were recorded. Parametric and non-parametric tests were employed. p< 0.05 was accepted as significant. Results: 260 patients were included (130 per cohort). The amount of postoperative bleeding was 713.1 +445.4 ml. 26.5% received ABT. BS reduced transfusion in 13,1% (p=0,024) with RR 1,65 (CI 1,085-2,52)]. Risk factors for postoperative bleeding were: male gender, atrial fibrillation, preoperative anti-platelet therapy and cementless primary TKA. Risk factors for ABT: ASA > II, preoperative hemoglobin < 13 g/dl, knee revision, anti-platelet therapy, longer surgery time. Patients transfused had lower hemoglobin values (p<0.001), and longer medium LOS (+2.5 days, p=0.026). Conclusion: The use of BS in TKA showed benefits reducing allogenic blood transfusion and length of hospital stay. BS would remain an effective, safe and cheap alternative to tranexamic acid in patients with high risk of thromboembolism events operated of TKA.
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