Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.rev08
J.M. Fernández-Rañada de la Gándara
Multiple myeloma is a plasma cell neoplasm that accounts for approximately 1-1.8% of cancer cases. It constitutes 10% of malignant blood diseases and is the 2nd most common hematopoietic tumor. In Spain, between 2,500 and 3,000 new cases are diagnosed per year with a median age at diagnosis of 69 years. A great effort has been made to try to improve MM survival, which has ranged from 3 years in the 1990s, to 5 years in the 2000s, and is currently of around 8-9 years. This improvement is due to a better definition of diagnostic, prognostic, and response to treatment criteria and to the successive introduction of new drugs: proteasome inhibitors, immunomodulators, and monoclonal antibodies. Differences have also been established in the therapeutic strategy for multiple myeloma depending on whether the patients are eligible for autologous transplantation of peripheral blood hematopoietic progenitors (TASPE) or ineligible patients. In the first case, the current standard treatment consists of the combination Daraturumab, Velcade, Thalidomide and Dexamethasone (DVTD) – a regime approved by the EMA (European Medicines Agency) – followed by the practice of TASPE and subsequent maintenance therapy with Lenalidomide with or without post-transplant consolidation. For patients who are not candidates for transplantation, current recommendations support the combination of Daraturumab, Revlimid, Dexamethasone (DRD) as the first therapeutic option, while other alternatives are the combination Daraturumab, Velcade, Melphalan, Prednisone (DVMP) or Velcade, Revlimid, Dexamethasone (VRD).
{"title":"Initial Therapy of Multiple Myeloma (MM)","authors":"J.M. Fernández-Rañada de la Gándara","doi":"10.32440/ar.2023.140.01.rev08","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev08","url":null,"abstract":"Multiple myeloma is a plasma cell neoplasm that accounts for approximately 1-1.8% of cancer cases. It constitutes 10% of malignant blood diseases and is the 2nd most common hematopoietic tumor. In Spain, between 2,500 and 3,000 new cases are diagnosed per year with a median age at diagnosis of 69 years. A great effort has been made to try to improve MM survival, which has ranged from 3 years in the 1990s, to 5 years in the 2000s, and is currently of around 8-9 years. This improvement is due to a better definition of diagnostic, prognostic, and response to treatment criteria and to the successive introduction of new drugs: proteasome inhibitors, immunomodulators, and monoclonal antibodies.\u0000Differences have also been established in the therapeutic strategy for multiple myeloma depending on whether the patients are eligible for autologous transplantation of peripheral blood hematopoietic progenitors (TASPE) or ineligible patients. In the first case, the current standard treatment consists of the combination Daraturumab, Velcade, Thalidomide and Dexamethasone (DVTD) – a regime approved by the EMA (European Medicines Agency) – followed by the practice of TASPE and subsequent maintenance therapy with Lenalidomide with or without post-transplant consolidation. For patients who are not candidates for transplantation, current recommendations support the combination of Daraturumab, Revlimid, Dexamethasone (DRD) as the first therapeutic option, while other alternatives are the combination Daraturumab, Velcade, Melphalan, Prednisone (DVMP) or Velcade, Revlimid, Dexamethasone (VRD).","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47457870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.rev03
J. A. Vargas Núñez, M. Yebra Bango, S. Mellor Pita, P. Tutor de Ureta, P. Durán del Campo, R. Castejón Díaz
Systemic autoimmune diseases, such systemic lupus erythematosus (SLE), show an increased morbidity and cardiovascular mortality and a higher incidence of early and accelerated atherosclerosis than the general population that cannot be explained only by the presence of classic risk factors such arterial hypertension, mellitus diabetes, hypercholesterolemia, obesity or smoking, but it seems to depend on factors associated with the disease. The imbalance between vascular damage and repair plays a critical role in the initiation of atherosclerotic lesion. This balance may be broken by factors associated with chronic inflammation, oxidative stress, pharmacological treatments, altered molecules and cells involved in the repair of the endothelium. Research is ongoing to identify biomarkers that can help clinicians to predict which SLE patients are the greatest risk for cardiovascular disease.
{"title":"Atherosclerosis and systemic lupus erythematosus","authors":"J. A. Vargas Núñez, M. Yebra Bango, S. Mellor Pita, P. Tutor de Ureta, P. Durán del Campo, R. Castejón Díaz","doi":"10.32440/ar.2023.140.01.rev03","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev03","url":null,"abstract":"Systemic autoimmune diseases, such systemic lupus erythematosus (SLE), show an increased morbidity and cardiovascular mortality and a higher incidence of early and accelerated atherosclerosis than the general population that cannot be explained only by the presence of classic risk factors such arterial hypertension, mellitus diabetes, hypercholesterolemia, obesity or smoking, but it seems to depend on factors associated with the disease. The imbalance between vascular damage and repair plays a critical role in the initiation of atherosclerotic lesion. This balance may be broken by factors associated with chronic inflammation, oxidative stress, pharmacological treatments, altered molecules and cells involved in the repair of the endothelium. Research is ongoing to identify biomarkers that can help clinicians to predict which SLE patients are the greatest risk for cardiovascular disease.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43109137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.rev05
J. Andreo-Lopez, M. Bettinetti-Luque, C. Campos-Moreno, A. Gutiérrez, D. Baglietto-Vargas
Alzheimer´s disease (AD) is a complex neurodegenerative disorder that affects mainly the elder population. To date, modifying therapies have not proven to be successful, and therefore, a major effort is necessary to unravel the pathogenic processes underlying AD. New evidences indicate that AD and many other neurodegenerative diseases have commonly the accumulation of misfolded proteins that have the potential to act as infectious agents, and propagate through the entire brain, affecting native proteins. The amyloid peptide (Aβ), characteristic of AD, can adopt a β-sheet conformation acquiring the potential to aggregate and generate misfolded intermediates that can act as ‘’seeds’’ to propagate disease in the brain. Recent findings suggest that these seeds are structurally different depending on the patients and AD subtype, showing different propagation capacity and toxicity. In order to find out which Aβ species or isoforms are more toxic and have greater potential to aggregate, brain extracts from AD patients have been inoculated into transgenic AD mice brains. These approaches have provided much information, however, most of the models contain one or multiple dominant mutations of familial AD cases. This is of great value to mimic the familial forms of the disease, but not the late onset AD (LOAD), which constitute the majority of the cases. Therefore, new animal models are urgently necessary to circumvent these limitations and properly dissect the pathogenic mechanisms of this common form of the disease. As such, a new humanized Aβ model, called hAβ-KI, that has been generated by UCI-MODEL AD center at California, recapitulates certain features of LOAD. This might represent a useful LOAD model to understand how Aβ spreads and favors the progression of the pathology in the brain, hopefully enabling the development of effective therapeutic interventions for AD.
{"title":"Aβ aggregation and propagation in transgenic models of Alzheimer’s disease","authors":"J. Andreo-Lopez, M. Bettinetti-Luque, C. Campos-Moreno, A. Gutiérrez, D. Baglietto-Vargas","doi":"10.32440/ar.2023.140.01.rev05","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev05","url":null,"abstract":"Alzheimer´s disease (AD) is a complex neurodegenerative disorder that affects mainly the elder population. To date, modifying therapies have not proven to be successful, and therefore, a major effort is necessary to unravel the pathogenic processes underlying AD. New evidences indicate that AD and many other neurodegenerative diseases have commonly the accumulation of misfolded proteins that have the potential to act as infectious agents, and propagate through the entire brain, affecting native proteins. The amyloid peptide (Aβ), characteristic of AD, can adopt a β-sheet conformation acquiring the potential to aggregate and generate misfolded intermediates that can act as ‘’seeds’’ to propagate disease in the brain. Recent findings suggest that these seeds are structurally different depending on the patients and AD subtype, showing different propagation capacity and toxicity. In order to find out which Aβ species or isoforms are more toxic and have greater potential to aggregate, brain extracts from AD patients have been inoculated into transgenic AD mice brains. These approaches have provided much information, however, most of the models contain one or multiple dominant mutations of familial AD cases. This is of great value to mimic the familial forms of the disease, but not the late onset AD (LOAD), which constitute the majority of the cases. Therefore, new animal models are urgently necessary to circumvent these limitations and properly dissect the pathogenic mechanisms of this common form of the disease. As such, a new humanized Aβ model, called hAβ-KI, that has been generated by UCI-MODEL AD center at California, recapitulates certain features of LOAD. This might represent a useful LOAD model to understand how Aβ spreads and favors the progression of the pathology in the brain, hopefully enabling the development of effective therapeutic interventions for AD.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47630282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.rev02
L. Martí-Bonmatí
Scientific and professional journals must clearly define their editorial line and their guidelines for action regarding the process of review and acceptance of the manuscripts they receive. The role of the Editor-in-Chief is very important in these aspects. This paper will review the actions taken in this regard in the journal Insights into Imaging that placed the journal in the first quartile by impact factor of journals in the area of imaging and radiology. This narrative emphasizes the importance of critical thinking focused on improving editorial processes, guaranteeing the veracity and authorship of the works, equity, plagiarism control, time adjustment from the receipt to the final decision, simplification of the editorial process, and commitment to foster disruptive articles maintaining a structure focused on the best available evidence. All these measures aim to promote the perceived quality of the journal and the immediate impact of publications.
{"title":"My experience as Editor-in-Chief of Insights into Imaging","authors":"L. Martí-Bonmatí","doi":"10.32440/ar.2023.140.01.rev02","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev02","url":null,"abstract":"Scientific and professional journals must clearly define their editorial line and their guidelines for action regarding the process of review and acceptance of the manuscripts they receive. The role of the Editor-in-Chief is very important in these aspects. This paper will review the actions taken in this regard in the journal Insights into Imaging that placed the journal in the first quartile by impact factor of journals in the area of imaging and radiology. This narrative emphasizes the importance of critical thinking focused on improving editorial processes, guaranteeing the veracity and authorship of the works, equity, plagiarism control, time adjustment from the receipt to the final decision, simplification of the editorial process, and commitment to foster disruptive articles maintaining a structure focused on the best available evidence. All these measures aim to promote the perceived quality of the journal and the immediate impact of publications.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49572441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.rev06
J. R. Ribera Casado
The consequences of climate changes are, at this moment, one of the greatest threats for human health, especially when we talk of older population. This paper collects same recent evidences coming from medical literature, with the enphasis foccussed on elderly people, preferent victims of these changes, due to the functional losses produced during the aging proccess. There is an increase in mortality and morbidity, especially among patients with chronic conditions and/or cardiac and respiratory diseases. There is, also, an increase in the incidence of infectious diseases attributable to air and water contamination, beause of a lower quality in their physical, chemical and biological propierties. Altough it is a global phenomenon, it incides most on victims from the poorest and less pepared countries. The last part of the paper offers, also according with reccent medical studies, some suggestions oriented on what we can do to limit these deletereous effects.
{"title":"Climate change, health and the elderly","authors":"J. R. Ribera Casado","doi":"10.32440/ar.2023.140.01.rev06","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev06","url":null,"abstract":"The consequences of climate changes are, at this moment, one of the greatest threats for human health, especially when we talk of older population. This paper collects same recent evidences coming from medical literature, with the enphasis foccussed on elderly people, preferent victims of these changes, due to the functional losses produced during the aging proccess. There is an increase in mortality and morbidity, especially among patients with chronic conditions and/or cardiac and respiratory diseases. There is, also, an increase in the incidence of infectious diseases attributable to air and water contamination, beause of a lower quality in their physical, chemical and biological propierties. Altough it is a global phenomenon, it incides most on victims from the poorest and less pepared countries. The last part of the paper offers, also according with reccent medical studies, some suggestions oriented on what we can do to limit these deletereous effects.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44024522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.ed01
B. Fernández-Gutiérrez
{"title":"Organoids: a powerful evolutive tool","authors":"B. Fernández-Gutiérrez","doi":"10.32440/ar.2023.140.01.ed01","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.ed01","url":null,"abstract":"","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69672396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.org01
N. Oreiro, R. Cáliz, A. Balsa, J. Andreu, R. Sanmartí, F. Blanco
Introduction and Objectives. Of all clinical manifestations that mark prognosis of a patient with RA, radiological damaged is considered one of the most important variables. In addition to clinical and laboratory markers are increasingly studying the influence of genetic factors in the predictive ability of the RA forecast. Previous studies have reported misleading results about polymorphisms in different genes associated with radiological damage in RA. The aim of this study was to assess the involvement of the clinical, analytical and genetic variables in the radiological damage in a Spanish RA population. Methods. Six hundred thirty-two Spanish RA patients were included. SNP genotyping was performed using an oligonucleotide microarray. Allele and genotype association analyses with articular damage and a haplotype association test were performed. Results. This study includes retrospectively 604 Spanish RA patients with articular erosions and 616 with surgery due to RA. The A587G polymorphism (rs3741240) in uteroglobin gene was associated with increased radiological damage defined by phenotypes RX2 (multiple erosions on hands and feet) and surgery due to RA (OR 1.6 and 1.7 respectively). IL2R polymorphism was associated with RX2 phenotype (OR 2.95). Disease duration, painful joints, ESR, RF and ACPA are the analytical and clinical variables significantly associated with articular damage. Conclusions. These results demonstrate that the A587G and C4599T polymorphism in uteroglobin and IL2R genes respectively are associated with radiological damage in a Spanish RA population.
{"title":"Uteroglobine and IL2R polymorphisms are associated with articular damaged and surgical joint in patients with Rheumatoid Arthritis","authors":"N. Oreiro, R. Cáliz, A. Balsa, J. Andreu, R. Sanmartí, F. Blanco","doi":"10.32440/ar.2023.140.01.org01","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.org01","url":null,"abstract":"Introduction and Objectives. Of all clinical manifestations that mark prognosis of a patient with RA, radiological damaged is considered one of the most important variables. In addition to clinical and laboratory markers are increasingly studying the influence of genetic factors in the predictive ability of the RA forecast. Previous studies have reported misleading results about polymorphisms in different genes associated with radiological damage in RA. The aim of this study was to assess the involvement of the clinical, analytical and genetic variables in the radiological damage in a Spanish RA population.\u0000Methods. Six hundred thirty-two Spanish RA patients were included. SNP genotyping was performed using an oligonucleotide microarray. Allele and genotype association analyses with articular damage and a haplotype association test were performed.\u0000Results. This study includes retrospectively 604 Spanish RA patients with articular erosions and 616 with surgery due to RA. The A587G polymorphism (rs3741240) in uteroglobin gene was associated with increased radiological damage defined by phenotypes RX2 (multiple erosions on hands and feet) and surgery due to RA (OR 1.6 and 1.7 respectively). IL2R polymorphism was associated with RX2 phenotype (OR 2.95). Disease duration, painful joints, ESR, RF and ACPA are the analytical and clinical variables significantly associated with articular damage.\u0000Conclusions. These results demonstrate that the A587G and C4599T polymorphism in uteroglobin and IL2R genes respectively are associated with radiological damage in a Spanish RA population.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42809557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.rev04
J. Ávila
The main risk factor for neurodegenerative disorders, like Alzheimer disease, is aging. At molecular level, aging correlates, in peripheral tissues and in the central nervous system with epigenetic changes at the chromatin (histones and DNA) of aged cells. These molecular changes can be reverted by the expression of the, so called, Yamanaka factors (YF). YF can reprogram (rejuvenate) old cells to cells with structural and functional characteristics of young cells. In the case of the nervous system, upon YF expression, an increase in cognitive capacity can be found. Our future objective, to extrapolate the results found in mice to the human being, will be to look for simple and small chemical compounds with a similar capacity, to that of YF, to revert the structural and functional changes found during aging development.
{"title":"Neuronal Aging – Is it reversible?","authors":"J. Ávila","doi":"10.32440/ar.2023.140.01.rev04","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev04","url":null,"abstract":"The main risk factor for neurodegenerative disorders, like Alzheimer disease, is aging. At molecular level, aging correlates, in peripheral tissues and in the central nervous system with epigenetic changes at the chromatin (histones and DNA) of aged cells. These molecular changes can be reverted by the expression of the, so called, Yamanaka factors (YF). YF can reprogram (rejuvenate) old cells to cells with structural and functional characteristics of young cells. In the case of the nervous system, upon YF expression, an increase in cognitive capacity can be found. Our future objective, to extrapolate the results found in mice to the human being, will be to look for simple and small chemical compounds with a similar capacity, to that of YF, to revert the structural and functional changes found during aging development.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42890101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.cc01
A. Reolid, B. Butrón, R. Sampedro, A. Miguélez, E. Daudén, M. Llamas‐Velasco
During the world pandemic coronavirus disease (COVID-19), an increase in herpesvirus infections has been observed in patients with COVID-19. We describe 3 patients with atypical clinical presentations of herpesvirus infection. In two of them we demonstrated the presence of several members of the Herpesviridae family in the same skin lesion, and in the other we found the coexistence of herpes simplex virus and varicella zoster virus. These coexistences are highly infrequent findings and hardly described in the literature. All our patients had lymphopenia. Since SARS-CoV-2 virus infection characteristically produces lymphopenia, we wondered whether COVID-19 may play a role as a predisposing factor to herpesvirus infections.
{"title":"Coexistence of herpesviridae family viruses in vesicular skin lesions of COVID-19 patients","authors":"A. Reolid, B. Butrón, R. Sampedro, A. Miguélez, E. Daudén, M. Llamas‐Velasco","doi":"10.32440/ar.2023.140.01.cc01","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.cc01","url":null,"abstract":"During the world pandemic coronavirus disease (COVID-19), an increase in herpesvirus infections has been observed in patients with COVID-19. We describe 3 patients with atypical clinical presentations of herpesvirus infection. In two of them we demonstrated the presence of several members of the Herpesviridae family in the same skin lesion, and in the other we found the coexistence of herpes simplex virus and varicella zoster virus. These coexistences are highly infrequent findings and hardly described in the literature. All our patients had lymphopenia. Since SARS-CoV-2 virus infection characteristically produces lymphopenia, we wondered whether COVID-19 may play a role as a predisposing factor to herpesvirus infections.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46880870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.32440/ar.2023.140.01.rev01
E. Moreno gonzález, A. García Sesma, C. Jiménez Romero, C. Loinaz Segurola, A. Manrique, J. Calvo, A. Marcacuzco
On 31 December 2019 COVID-19 Viral infection was diagnoses. On june 2020 only in 188 countries 33 millons of infected people were detected. Unfortunately in Spain the results of the treatment has been worse than in Germany, Italy, Corea, Taiwan., Grece, Portugal, France, Japan, and others. 778 transplanted patients were infected. 249 of them in Madrid area. Organ donation was reduced. National Organization of Organ Trasplantation diminished donation, and transplantation of kidney, liver, heart, lung close to 90% (in april, 0%) from march to july 2020. Living rolated or split, and cluster trasplantation was not permited. In Madrid area, on 2020 were done 37 transplantation less than in 2019 the causes of that were the reduction of UCI beds, time in the OR, reduction of doctors and nurses. 861.112 infected people, 32.992 died and from the total number of patients, 36.000 were included as, doctors, nurses and other related with health care areas new protocols, hospitals, intensive care areas, etc were established along 2020 going back to the previous results obtained during 2018-2019.
{"title":"Modifications or organ transplantation due to viral infection by Covid 19","authors":"E. Moreno gonzález, A. García Sesma, C. Jiménez Romero, C. Loinaz Segurola, A. Manrique, J. Calvo, A. Marcacuzco","doi":"10.32440/ar.2023.140.01.rev01","DOIUrl":"https://doi.org/10.32440/ar.2023.140.01.rev01","url":null,"abstract":"On 31 December 2019 COVID-19 Viral infection was diagnoses. On june 2020 only in 188 countries 33 millons of infected people were detected. Unfortunately in Spain the results of the treatment has been worse than in Germany, Italy, Corea, Taiwan., Grece, Portugal, France, Japan, and others. 778 transplanted patients were infected. 249 of them in Madrid area. Organ donation was reduced. National Organization of Organ Trasplantation diminished donation, and transplantation of kidney, liver, heart, lung close to 90% (in april, 0%) from march to july 2020. Living rolated or split, and cluster trasplantation was not permited. In Madrid area, on 2020 were done 37 transplantation less than in 2019 the causes of that were the reduction of UCI beds, time in the OR, reduction of doctors and nurses. 861.112 infected people, 32.992 died and from the total number of patients, 36.000 were included as, doctors, nurses and other related with health care areas new protocols, hospitals, intensive care areas, etc were established along 2020 going back to the previous results obtained during 2018-2019.","PeriodicalId":75487,"journal":{"name":"Anales de la Real Academia Nacional de Medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46442588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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