两种光固化单元聚合后不同树脂复合材料的生物相容性:免疫组织化学研究

IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE European Oral Research Pub Date : 2024-01-05 DOI:10.26650/eor.20231260787
Irem Ipek, Murat Unal, Tulay Koc
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引用次数: 0

摘要

目的:本研究旨在比较两种不同树脂复合材料在两种不同光源下聚合后在三个不同时间段内的生物相容性。材料和方法:在 18 只大鼠的背结缔组织中植入 72 支用两种不同树脂复合材料和两种不同光源(Elipar S10 和 Valo)聚合的聚乙烯管[第 1 组:Kalore Elipar S10 (KE);第 2 组:Kalore Valo (KV);第 3 组:Essentia Elipar S10 (EE);第 4 组:Essentia Valo (EV)]。在 6 只大鼠的背结缔组织中植入 24 支空聚乙烯管[第 5 组:(对照组)]。然后,在第 7 天、第 15 天和第 30 天的每个时间间隔(n=8)后将大鼠处死。活检样本用 H&E 染色,检查炎症、坏死、巨噬细胞浸润、巨细胞和纤维囊标准。免疫组化染色用于评估促炎细胞因子(IL-1β、IL-6 和 IL-8):综合组与对照组比较,第 7 天和第 15 天的炎症标准差异有统计学意义,而纤维囊和坏死标准在各时间点之间无统计学差异。在对复合组和对照组的促炎细胞因子进行评估时,发现第 7 天、第 15 天和第 30 天的差异有统计学意义:本研究中使用的所有 CR 在使用不同光源聚合后,在大鼠皮下组织中均表现出可接受的生物相容性。
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Biocompatibility of different resin composites after polymerization with two light curing units: an immunohistochemical study.

Purpose: The aim of this study is to compare the biocompatibility of two different resin composites after polymerization under two different light sources in three different time periods.

Materials and methods: 72 polyethylene tubes polymerized with 2 different resin composites and 2 different light sources (Elipar S10 and Valo ) [Group 1: Kalore Elipar S10 (KE), Group 2: Kalore Valo (KV), Group 3: Essentia Elipar S10 (EE), Group 4: Essentia Valo (EV)] were implanted in the dorsal connective tissue of 18 rats. 24 empty polyethylene tubes [Group 5: (Control group)] were implanted in the dorsal connective tissue of 6 rats. Then, the rats were sacrificed after 7th, 15th and 30th days in each time intervals (n=8). Biopsy samples were stained with H&E and examined for inflammation, necrosis, macrophage infiltrate, giant cell and fibrous capsule criteria. Immunohistochemical staining was performed to evaluate proinflammatory cytokines (IL-1β, IL-6 and IL-8).

Results: When the composite groups and the control groups were compared; the difference was statistically significant for the criteria of inflammation at 7th and 15th days, there was no statistical difference between the time points in terms of fibrous capsule and necrosis. When the composite groups and control groups were evaluated in terms of proinflammatory cytokines; statistically significant differences were found at 7th, 15th and 30th days.

Conclusion: All CRs used in this study showed acceptable biocompatibility in the subcutaneous tissues of rats after polymerization with different light sources.

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来源期刊
European Oral Research
European Oral Research DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
1.60
自引率
0.00%
发文量
23
审稿时长
12 weeks
期刊最新文献
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