Fetuína-A plasmática en pacientes con preeclampsia y gestantes normotensas sanas

Objective

To compare plasma fetuin-A concentrations in patients with preeclampsia and healthy normotensive pregnant women.

Materials and method

A total of 100 patients were selected. Fifty patients with preeclampsia were selected as cases (Group A), and a control group selected with the same age and body mass index as the study group that consisted of 50 healthy normotensive pregnant women (Group B). Blood samples were collected from all patients before labour, and immediately after diagnosis in Group B to determine plasma fetuin-A concentrations.

Results

There was a statistically significant difference in plasma fetuin-A concentrations between patients in group A (279.1 ± 29.1 pg/ml) and patients in group B (328.1 ± 37.2; p<.001). There was no significant correlation with values of systolic and diastolic blood pressure (p= ns). Significant correlations were found between fetuin-A and aspartate transaminases (p<.05). A cut-off value of 300 pg/ml had a value under the curve of 0.86, sensitivity of 79.3%, specificity of 70.7%, a positive predictive value of 65.7%, and a negative predictive value of 82.6%.

Conclusion

Patients with preeclampsia had significantly higher plasma concentrations of fetuin-A when compared with healthy normotensive pregnant women.