用于药物递送系统的细胞外囊泡的纳米工程：当前进展和未来方向

Q2 Pharmacology, Toxicology and Pharmaceutics OpenNano Pub Date : 2023-05-01 DOI:10.1016/j.onano.2023.100130

Ali Afzal , Muhammad Babar Khawar , Ume Habiba , Sara Shahzaman , Syeda Eisha Hamid , Mussarat Rafiq , Muddasir Hassan Abbasi , Nadeem Sheikh

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引用次数: 2

摘要

细胞外囊泡(EVs)作为天然的药物传递载体，由于其相对较高的效率，在药物传递系统中获得了很高的声誉。目前的文献通过探索其生物发生、表征和纳米工程技术等各个方面，推动了ev在药物输送中的应用，从而使其从实验室应用到临床，并优化了良好的实验室实践。在这篇及时的综述中，我们总结了电动汽车表征的现状以及电动汽车在载货和表面制造方面的纳米工程的最新进展。此外，我们还回顾了目前在临床转化和ev在临床试验中的意义方面的进展以及未来的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nanoengineering of extracellular vesicles for drug delivery systems: Current advances and future directions

Extracellular Vesicles (EVs) have gained high repute in drug delivery systems owing to their relatively higher efficacy as natural drug delivery vehicles. The current literature has advanced the use of EVs in drug delivery through exploring various aspects including their biogenesis, characterization, and nanoengineering techniques thereby leading them from laboratory to clinical use with optimized good laboratory practices. In this timely review, we summarize the current status of EVs characterizations and recent updates on nanoengineering of EVs regarding Cargo loading and surface fabrication. Further, we have also reviewed current progress in clinical translation and implications of EVs in clinical trials together with future recommendations.

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来源期刊

OpenNano Medicine-Pharmacology (medical)

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

50 days

期刊介绍： OpenNano is an internationally peer-reviewed and open access journal publishing high-quality review articles and original research papers on the burgeoning area of nanopharmaceutics and nanosized delivery systems for drugs, genes, and imaging agents. The Journal publishes basic, translational and clinical research as well as methodological papers and aims to bring together chemists, biochemists, cell biologists, material scientists, pharmaceutical scientists, pharmacologists, clinicians and all others working in this exciting and challenging area.