结合网络药理学和分子对接,鉴定黑草治疗多发性硬化症的关键基因和治疗靶点

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL BioMedicine-Taiwan Pub Date : 2023-07-01 DOI:10.51248/.v43i3.2867
Hardi Kapadia, Divya Vora, Dinesh S. Manjegowda, A. Nair, Sameer Sharma, Susha Dinesh
{"title":"结合网络药理学和分子对接,鉴定黑草治疗多发性硬化症的关键基因和治疗靶点","authors":"Hardi Kapadia, Divya Vora, Dinesh S. Manjegowda, A. Nair, Sameer Sharma, Susha Dinesh","doi":"10.51248/.v43i3.2867","DOIUrl":null,"url":null,"abstract":"Introduction and Aim: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting around 2.8 million people worldwide. MS pathophysiology is not yet explained up to the mark, which is the cause of difficulty and complexity in treating the illness. Most present-day scenarios are engrossed in inhibiting central nervous system (CNS) inflammation. However, this is not enough, hence the present study aims at finding best neuroprotective treatment without adverse effects.\n \nMaterials and Methods: In silico attempt to validate the phytocompounds from Nigella sativa and showcase their use for targeting the neuroprotective mechanism involved in management of MS by finding the key potential genes which were derived from mRNA datasets of previous research. Various bioinformatics tools and software such as GEO, String, ShinyGO, PyRx were used to carry out the current study. The leading steps involve retrieval of targets from mRNA datasets, molecular docking of phytocompounds with the targets and pharmacological analysis.\n \nResults: These phytocompounds from seeds of N. sativa showed promising results as therapeutic agents against target genes RPL27, RPS14 and FAU for management of MS during current in silico study, but any treatment prior its clinical practice should validate with large robust data, which lies as the future prospective here.\n \nConclusion: In summary notable progress in management of MS with better understanding of pathology has been made and many disease modifying therapies (DMT) are made available but the question of safety and efficacy is still challenging due to adverse effects associated with these therapies. Hence properties of N. sativa must be explored as a therapeutic agent that can reduce the neuronal degeneration.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Integrating network pharmacology and molecular docking for the identification of key genes and therapeutic targets of Nigella sativa in multiple sclerosis treatment\",\"authors\":\"Hardi Kapadia, Divya Vora, Dinesh S. Manjegowda, A. Nair, Sameer Sharma, Susha Dinesh\",\"doi\":\"10.51248/.v43i3.2867\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction and Aim: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting around 2.8 million people worldwide. MS pathophysiology is not yet explained up to the mark, which is the cause of difficulty and complexity in treating the illness. Most present-day scenarios are engrossed in inhibiting central nervous system (CNS) inflammation. However, this is not enough, hence the present study aims at finding best neuroprotective treatment without adverse effects.\\n \\nMaterials and Methods: In silico attempt to validate the phytocompounds from Nigella sativa and showcase their use for targeting the neuroprotective mechanism involved in management of MS by finding the key potential genes which were derived from mRNA datasets of previous research. Various bioinformatics tools and software such as GEO, String, ShinyGO, PyRx were used to carry out the current study. The leading steps involve retrieval of targets from mRNA datasets, molecular docking of phytocompounds with the targets and pharmacological analysis.\\n \\nResults: These phytocompounds from seeds of N. sativa showed promising results as therapeutic agents against target genes RPL27, RPS14 and FAU for management of MS during current in silico study, but any treatment prior its clinical practice should validate with large robust data, which lies as the future prospective here.\\n \\nConclusion: In summary notable progress in management of MS with better understanding of pathology has been made and many disease modifying therapies (DMT) are made available but the question of safety and efficacy is still challenging due to adverse effects associated with these therapies. Hence properties of N. sativa must be explored as a therapeutic agent that can reduce the neuronal degeneration.\",\"PeriodicalId\":51650,\"journal\":{\"name\":\"BioMedicine-Taiwan\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BioMedicine-Taiwan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.51248/.v43i3.2867\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioMedicine-Taiwan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51248/.v43i3.2867","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

简介和目的:多发性硬化症(MS)是一种慢性神经退行性疾病,影响全球约280万人。多发性硬化症的病理生理尚未完全解释清楚,这是治疗该病困难和复杂的原因。目前大多数情况下,集中在抑制中枢神经系统(CNS)炎症。然而,这是不够的,因此本研究的目的是寻找最佳的无副作用的神经保护治疗。材料和方法:通过从前期研究的mRNA数据集中寻找关键潜在基因,验证黑草植物化合物的有效性,并展示其在MS治疗中针对神经保护机制的应用。使用GEO、String、ShinyGO、PyRx等多种生物信息学工具和软件开展本研究。主要步骤包括从mRNA数据集中检索靶点,植物化合物与靶点的分子对接以及药理分析。结果:这些来自sativa种子的植物化合物作为靶向基因RPL27、RPS14和FAU治疗MS的药物在目前的计算机研究中显示出良好的效果,但任何治疗在临床实践之前都需要大量可靠的数据验证,这是未来的前景。结论:总的来说,随着对病理的更好理解,MS的治疗取得了显著进展,许多疾病修饰疗法(DMT)已经可用,但由于这些疗法的不良反应,安全性和有效性问题仍然具有挑战性。因此,作为一种能够减少神经元变性的治疗剂,必须探索芥蓝的特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Integrating network pharmacology and molecular docking for the identification of key genes and therapeutic targets of Nigella sativa in multiple sclerosis treatment
Introduction and Aim: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting around 2.8 million people worldwide. MS pathophysiology is not yet explained up to the mark, which is the cause of difficulty and complexity in treating the illness. Most present-day scenarios are engrossed in inhibiting central nervous system (CNS) inflammation. However, this is not enough, hence the present study aims at finding best neuroprotective treatment without adverse effects.   Materials and Methods: In silico attempt to validate the phytocompounds from Nigella sativa and showcase their use for targeting the neuroprotective mechanism involved in management of MS by finding the key potential genes which were derived from mRNA datasets of previous research. Various bioinformatics tools and software such as GEO, String, ShinyGO, PyRx were used to carry out the current study. The leading steps involve retrieval of targets from mRNA datasets, molecular docking of phytocompounds with the targets and pharmacological analysis.   Results: These phytocompounds from seeds of N. sativa showed promising results as therapeutic agents against target genes RPL27, RPS14 and FAU for management of MS during current in silico study, but any treatment prior its clinical practice should validate with large robust data, which lies as the future prospective here.   Conclusion: In summary notable progress in management of MS with better understanding of pathology has been made and many disease modifying therapies (DMT) are made available but the question of safety and efficacy is still challenging due to adverse effects associated with these therapies. Hence properties of N. sativa must be explored as a therapeutic agent that can reduce the neuronal degeneration.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
BioMedicine-Taiwan
BioMedicine-Taiwan MEDICINE, GENERAL & INTERNAL-
CiteScore
2.80
自引率
5.90%
发文量
21
审稿时长
24 weeks
期刊最新文献
Acute kidney injury induced lithium toxicity with concomitant neuroleptic malignant syndrome. Effect of Mucuna pruriens seed extract on depression-like behavior derived from mild traumatic brain injury in rats. Effect of alantolactones on cardiac parameters of animals under artificially induced oxidative stress. Effect of inulin from dahlia tubers (Dahlia variabilis) extract on insulitis severity and insulin expression in diabetic rats. Loss of tyrosine 211 phosphorylation of proliferating cell nuclear antigen (PCNA) enhances postnatal mammary gland development.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1