{"title":"脓毒症期间不同T细胞亚群的免疫代谢","authors":"Pinhao Guo, Lulong Bo","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.02.019","DOIUrl":null,"url":null,"abstract":"Aberrant activation of innate immune cells and immunosuppression are part of the pathogenesis of sepsis. The loss of CD4+ T cells, CD8+ T cells, Th17 cells, γδT cells, upregulation of regulatory T cells (Tregs) and aberrant immune cell metabolism can be detected in the stage of immunosuppression. Summarizing and analyzing the influence of immunometabolism of immune cells (CD4+ T cells, CD8+ T cells, Th17, Tregs and γδT) during sepsis-induced immunosuppression on regulating the function of T cells are helpful to investigate potential target of the immunometabolism of T cells. This review is benefit to explore novel immunometabolism therapeutic method to treat sepsis. \n \n \nKey words: \nSepsis; Immunosuppression; Immunometabolism; T cells","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"212-216"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immunometabolism of different T cell subsets during sepsis\",\"authors\":\"Pinhao Guo, Lulong Bo\",\"doi\":\"10.3760/CMA.J.ISSN.1673-4378.2020.02.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aberrant activation of innate immune cells and immunosuppression are part of the pathogenesis of sepsis. The loss of CD4+ T cells, CD8+ T cells, Th17 cells, γδT cells, upregulation of regulatory T cells (Tregs) and aberrant immune cell metabolism can be detected in the stage of immunosuppression. Summarizing and analyzing the influence of immunometabolism of immune cells (CD4+ T cells, CD8+ T cells, Th17, Tregs and γδT) during sepsis-induced immunosuppression on regulating the function of T cells are helpful to investigate potential target of the immunometabolism of T cells. This review is benefit to explore novel immunometabolism therapeutic method to treat sepsis. \\n \\n \\nKey words: \\nSepsis; Immunosuppression; Immunometabolism; T cells\",\"PeriodicalId\":13847,\"journal\":{\"name\":\"国际麻醉学与复苏杂志\",\"volume\":\"41 1\",\"pages\":\"212-216\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际麻醉学与复苏杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.02.019\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际麻醉学与复苏杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.02.019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunometabolism of different T cell subsets during sepsis
Aberrant activation of innate immune cells and immunosuppression are part of the pathogenesis of sepsis. The loss of CD4+ T cells, CD8+ T cells, Th17 cells, γδT cells, upregulation of regulatory T cells (Tregs) and aberrant immune cell metabolism can be detected in the stage of immunosuppression. Summarizing and analyzing the influence of immunometabolism of immune cells (CD4+ T cells, CD8+ T cells, Th17, Tregs and γδT) during sepsis-induced immunosuppression on regulating the function of T cells are helpful to investigate potential target of the immunometabolism of T cells. This review is benefit to explore novel immunometabolism therapeutic method to treat sepsis.
Key words:
Sepsis; Immunosuppression; Immunometabolism; T cells
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