Dineo Mpanya, Mike Sathekge, Eric Klug, Jenna Damelin, Stuart More, Bawinile Hadebe, Mariza Vorster, Nqoba Tsabedze
{"title":"镓-68成纤维细胞活化蛋白抑制剂在心血管疾病中的正电子发射断层扫描","authors":"Dineo Mpanya, Mike Sathekge, Eric Klug, Jenna Damelin, Stuart More, Bawinile Hadebe, Mariza Vorster, Nqoba Tsabedze","doi":"10.3389/fnume.2023.1224905","DOIUrl":null,"url":null,"abstract":"<p><p>Gallium-68 fibroblast activation protein inhibitor [(<sup>68</sup>Ga)Ga-FAPI] is a new radiopharmaceutical positioning itself as the preferred agent in patients with malignant tumours, competing with 2-Deoxy-2-[18F]fluoro-d-glucose [2-(<sup>18</sup>F)FDG] using positron emission tomography (PET). While imaging oncology patients with [<sup>68</sup>Ga]Ga-FAPI PET, incidental uptake of [<sup>68</sup>Ga]Ga-FAPI has been detected in the myocardium. This review summarises original research studies associating the visualisation of FAPI-based tracers in the myocardium with underlying active cardiovascular disease.</p>","PeriodicalId":73095,"journal":{"name":"Frontiers in nuclear medicine (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440833/pdf/","citationCount":"0","resultStr":"{\"title\":\"Gallium-68 fibroblast activation protein inhibitor positron emission tomography in cardiovascular disease.\",\"authors\":\"Dineo Mpanya, Mike Sathekge, Eric Klug, Jenna Damelin, Stuart More, Bawinile Hadebe, Mariza Vorster, Nqoba Tsabedze\",\"doi\":\"10.3389/fnume.2023.1224905\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gallium-68 fibroblast activation protein inhibitor [(<sup>68</sup>Ga)Ga-FAPI] is a new radiopharmaceutical positioning itself as the preferred agent in patients with malignant tumours, competing with 2-Deoxy-2-[18F]fluoro-d-glucose [2-(<sup>18</sup>F)FDG] using positron emission tomography (PET). While imaging oncology patients with [<sup>68</sup>Ga]Ga-FAPI PET, incidental uptake of [<sup>68</sup>Ga]Ga-FAPI has been detected in the myocardium. This review summarises original research studies associating the visualisation of FAPI-based tracers in the myocardium with underlying active cardiovascular disease.</p>\",\"PeriodicalId\":73095,\"journal\":{\"name\":\"Frontiers in nuclear medicine (Lausanne, Switzerland)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-07-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440833/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in nuclear medicine (Lausanne, Switzerland)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/fnume.2023.1224905\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in nuclear medicine (Lausanne, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fnume.2023.1224905","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Gallium-68 fibroblast activation protein inhibitor positron emission tomography in cardiovascular disease.
Gallium-68 fibroblast activation protein inhibitor [(68Ga)Ga-FAPI] is a new radiopharmaceutical positioning itself as the preferred agent in patients with malignant tumours, competing with 2-Deoxy-2-[18F]fluoro-d-glucose [2-(18F)FDG] using positron emission tomography (PET). While imaging oncology patients with [68Ga]Ga-FAPI PET, incidental uptake of [68Ga]Ga-FAPI has been detected in the myocardium. This review summarises original research studies associating the visualisation of FAPI-based tracers in the myocardium with underlying active cardiovascular disease.
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