A systemic review on efficacy and safety of multi-oil fat emulsion injection in premature infant parenteral nutrition support based on the meta-analysis

Objective To systemically analyze the efficacy and safety of multi-oil fat emulsion injection (SMOF) in the premature infant parenteral nutrition support. Methods Databases including EMbase, PubMed, Cochrane Library, CNKI, VIP and Wanfang, were searched from libraries establishment to November 2017 for randomized controlled trials (RCTs) focusing on the efficacy and safety of SMOF in the premature infant parenteral nutrition support. All the literatures were retrieved and screened according to inclusion and exclusion criteria by two researchers. The software RevMan 5.3 was used for meta-analysis after the evaluation of methodology of quality. Results A total of 7 articles including 7 RCTs were enrolled. Meta-analysis showed that there were no significant differences in body length (OR=-0.25, 95% CI=-1.80-1.30, P=0.75), weight(OR=-0.12, 95% CI=-0.20-0.04, P=0.14), head circumference(OR=0.07, 95% CI=-0.83-0.96, P=0.88), low-density lipoprotein, high-density lipoprotein, direct bilirubin, serum creatinine(OR=-0.16, 95% CI=-0.59-0.26, P=0.45) between the infants receiving SMOF or Intralipid. But compared with the infants receiving Intralipid, hemoglobin(OR=-0.75, 95% CI=-1.49-0.00, P=0.05), red blood cells(OR=-0.23, 95% CI=-0.45-0.00, P=0.05) decreased in the infants receiving SMOF, and white blood cells(OR=1.91, 95% CI=0.46-3.37, P=0.01) increased. Conclusions SMOF can control the hemoglobin content in serum, reduce the risk and degree of jaundice in premature infant, with better safety. Key words: Multi-oil fat emulsion injection; Premature infant; Meta-analysis; Randomized controlled trials; Efficacy; Safety