与体弱多病的老年人跌倒有关的因素——巴西的一项病例对照研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-06-30 DOI:10.1007/s12126-022-09503-8

Thais Bueno Enes, Cristina Sanches, Lorena Rocha Ayres, Gustavo Machado Rocha, Laila Nathieline Gonçalves Rodrigues Madureira, Daniele Aparecida de Souza, Carl Schneider, Jéssica Azevedo Aquino, André Oliveira Baldoni

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引用次数: 0

摘要

方法这是一项按性别和年龄配对的病例对照研究，病例被定义为去年自我报告跌倒的体弱老年人，对照组被定义为没有跌倒报告的体弱老年。采用条件logistic回归分析比值比（OR），置信区间为95%。主要结果指标：体弱老年人跌倒的发生与以下临床和药物流行病学因素有关：尿失禁和多药治疗。结果本组老年人1028名，病例组514名，对照组514人。跌倒的患病率为26.5%。多药治疗、使用不符合Beers标准的药物以及增加跌倒风险的药物的频率分别为58%、85%和87%。根据使用的量表类型，具有抗胆碱能特性的药物的使用频率在12%至65%之间。据观察，跌倒与尿失禁（OR 1.73，95%CI 1.28-2.34）和使用五种或五种以上药物（OR 1.68，95%CI 1.30-2.17）有关。

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Factors associated with falls in frail older persons—a case control study in Brazil

Method

This is a case-control study paired by sex and age, with the cases defined as frail older persons with self-reported falls in the last year and controls as frail older persons with no fall report. Odds ratio (OR) was analyzed by means of conditional logistic regression, with a 95% confidence interval. Main outcome measure: The occurrence of falls in frail older persons is associated with the following clinical and pharmacoepidemiological factors: urinary incontinence and polypharmacy.

Results

The sample consisted of 1028 older persons, 514 in the case group and 514 in the control group. The prevalence of falls was 26.5%. The frequency of polypharmacy, use of drugs inappropriate according to Beers’ criteria and drugs that increase the risk of falls were 58%, 85% and 87%. The frequency of drugs with anticholinergic properties ranged from 12 to 65% according to the type of scale used. It was observed that the fall is associated with urinary incontinence (OR 1.73, 95% CI 1.28–2.34) and use of five or more medications (OR 1.68, 95% CI, 1.30–2.17).

Conclusions

With this research, is possible to conclude that falling in the frail older persons is associated with the use of five or more drugs and the presence of urinary incontinence.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.