基于图拉普拉斯和双稀疏约束的主成分分析在多视图数据特征选择和样本聚类中的应用

IF 1.1 4区 生物学 Q4 GENETICS & HEREDITY Human Heredity Pub Date : 2019-08-29 DOI:10.1159/000501653
Ming-Juan Wu, Ying-Lian Gao, Jin-Xing Liu, Rong Zhu, Juan Wang
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引用次数: 2

摘要

主成分分析(PCA)是一种广泛用于评估低维数据的方法。已经提出了主成分分析的一些变体,以改进对主成分的解释。最常见的方法之一是稀疏主成分分析,其目的是找到稀疏基以提高主成分分析的可解释性。然而,由于数据中仍然包含冗余的PC,这些改进方法的性能仍远不能令人满意。本文提出了一种新的基于图拉普拉斯和双稀疏约束的PCA方法,以改进PC的解释并考虑数据的内部几何。详细地说,GDPCA同时利用L2,1-形式和L1规范正则化项,通过过滤冗余和不相关的PC来强制矩阵稀疏,其中L2,1-类型正则化项可以产生行稀疏性,而L1规范正则性项可以强制元素稀疏性。这样,我们可以在低维子空间中更好地解释新的PC。同时,GDSPCA方法将图拉普拉斯算子集成到PCA中,以探索隐藏在数据中的几何结构。提供了一种简单有效的优化解决方案。在多视图生物数据上进行的大量实验证明了所提出方法的可行性和有效性。
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Principal Component Analysis Based on Graph Laplacian and Double Sparse Constraints for Feature Selection and Sample Clustering on Multi-View Data
Principal component analysis (PCA) is a widely used method for evaluating low-dimensional data. Some variants of PCA have been proposed to improve the interpretation of the principal components (PCs). One of the most common methods is sparse PCA which aims at finding a sparse basis to improve the interpretability over the dense basis of PCA. However, the performances of these improved methods are still far from satisfactory because the data still contain redundant PCs. In this paper, a novel method called PCA based on graph Laplacian and double sparse constraints (GDSPCA) is proposed to improve the interpretation of the PCs and consider the internal geometry of the data. In detail, GDSPCA utilizes L2,1-norm and L1-norm regularization terms simultaneously to enforce the matrix to be sparse by filtering redundant and irrelative PCs, where the L2,1-norm regularization term can produce row sparsity, while the L1-norm regularization term can enforce element sparsity. This way, we can make a better interpretation of the new PCs in low-dimensional subspace. Meanwhile, the method of GDSPCA integrates graph Laplacian into PCA to explore the geometric structure hidden in the data. A simple and effective optimization solution is provided. Extensive experiments on multi-view biological data demonstrate the feasibility and effectiveness of the proposed approach.
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来源期刊
Human Heredity
Human Heredity 生物-遗传学
CiteScore
2.50
自引率
0.00%
发文量
12
审稿时长
>12 weeks
期刊介绍: Gathering original research reports and short communications from all over the world, ''Human Heredity'' is devoted to methodological and applied research on the genetics of human populations, association and linkage analysis, genetic mechanisms of disease, and new methods for statistical genetics, for example, analysis of rare variants and results from next generation sequencing. The value of this information to many branches of medicine is shown by the number of citations the journal receives in fields ranging from immunology and hematology to epidemiology and public health planning, and the fact that at least 50% of all ''Human Heredity'' papers are still cited more than 8 years after publication (according to ISI Journal Citation Reports). Special issues on methodological topics (such as ‘Consanguinity and Genomics’ in 2014; ‘Analyzing Rare Variants in Complex Diseases’ in 2012) or reviews of advances in particular fields (‘Genetic Diversity in European Populations: Evolutionary Evidence and Medical Implications’ in 2014; ‘Genes and the Environment in Obesity’ in 2013) are published every year. Renowned experts in the field are invited to contribute to these special issues.
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