月桂叶提取物合成氧化锌纳米颗粒及其抑菌活性研究

E. Önem, Firdevs MERT SİVRİ, S. Akkoç, Cennet Çirrik, Aleyna Ezer
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引用次数: 0

摘要

纳米技术最近已成为现代材料科学的一个重要研究领域。利用植物提取物绿色合成纳米颗粒具有成本效益高、环境友好、适合大规模生产的特点,因此备受关注。该研究重点介绍了使用月桂(L.nobilis)叶提取物合成ZnO纳米颗粒(ZnO NPs)的方法及其在生物医学领域的潜在应用的表征和生物活性。利用月桂叶提取物合成了ZnO纳米颗粒。通过紫外-可见光谱、透射电镜、X射线衍射和红外光谱对合成的ZnO纳米颗粒进行了表征。根据TEM和XRD衍射分析,合成的ZnO纳米颗粒的平均粒径为16±5nm,含有六方纤锌矿结构。ZnO纳米粒子对革兰氏阳性金黄色葡萄球菌(S.aureus)和革兰氏阴性大肠杆菌(E.coli)具有抗菌活性。采用MTT法检测了ZnO纳米粒子对人结肠癌癌症细胞株和小鼠正常成纤维细胞株的抗增殖活性。结果表明,所制备的纳米颗粒在筛选的培养时间和浓度下具有抗增殖活性。
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Biosynthesis of ZnO nanoparticles using Laurus nobilis leaf extract and investigation of antiproliferative and antibacterial activity potential
Nanotechnology has recently emerged as an essential field of study in modern materials science. The green synthesis of nanoparticles using plant extracts is of great interest because it is cost-effective, eco-friendly, and suitable for large-scale production. The study highlights the synthesis of ZnO nanoparticles (ZnO NPs) using Laurus nobilis (L. nobilis) leaf extract and their characterization and biological activities for potential applications in the biomedical field. ZnO NPs were synthesized using Laurus nobilis leaf extract. The synthesized ZnO NPs were characterized by UV-Vis spectroscopy, TEM, XRD, and FT-IR. According to TEM and XRD diffraction analysis, with a mean particle size of 16 ± 5 nm, it was found that the synthesized ZnO NPs contain a hexagonal wurtzite structure. ZnO NPs have antibacterial activity against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). The antiproliferative activity of ZnO NPs was tested against the human colon cancer cell line and mouse normal fibroblast cell line using MTT assay in vitro. The results show that the prepared nanoparticles had antiproliferative in screened incubation time and concentrations.
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来源期刊
International Journal of Secondary Metabolite
International Journal of Secondary Metabolite Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
1.40
自引率
0.00%
发文量
28
期刊最新文献
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