帕金森病患者脑白质增高与认知功能障碍关系的研究进展

Q4 Medicine 中国现代神经疾病杂志 Pub Date : 2017-11-25 DOI:10.3969/cjcnn.v17i11.1694

F. Hu, Zun-sheng Zhang, Xinhong Yang

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引用次数: 0

摘要

帕金森病（PD）是老年人常见的神经退行性疾病，其中认知障碍是影响患者生活质量的最常见的非运动症状。认知障碍与多种因素有关，白质高信号（WMH）是PD认知障碍的一种重要病理变化。本文将从神经元通路、白质体积变化和扩散张量成像（DTI）的角度解释WMH与PD认知障碍之间的关系，为帕金森病的早期诊断提供新的方向。DOI:10.3969/j.issn.1672-67312017.11.012

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Research progress of relationship between white matter hyperintensity and cognitive impairment in Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disease in the elderly, of which cognitive impairment is the most common non-motor symptom (NMS) affecting the life quality of patients. Cognitive impairment is associated with many factors, and white matter hyperintensity (WMH) is an important pathological change of cognitive impairment in PD. In this paper, we will explain the relationship between WMH and cognitive impairment in PD by the perspective of neuronal pathway, white matter volume change and diffusion tensor imaging (DTI), to provide a new direction for the early diagnosis of PD. DOI: 10.3969/j.issn.1672-6731.2017.11.012

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