巨噬细胞先天免疫记忆研究进展

S. Khan, M. U. Khan
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引用次数: 2

摘要

免疫通常分为两类:先天免疫和适应性免疫,其区别在于免疫影响的过程和特征。人们普遍认为,只有适应性免疫才具有记忆特征;然而,目前的研究表明,先天免疫和适应性免疫一样,也具有记忆特性。“训练免疫”,也称为“先天免疫记忆”,是一种当免疫系统的先天细胞受到刺激,然后经历表观遗传重编程和代谢改变时发生的现象。当涉及到先天免疫时,巨噬细胞是必不可少的,因为它们具有免疫记忆能力,并在身体免疫中发挥重要作用。先天免疫记忆的概念扩展了免疫记忆的定义,并为免疫反应研究提供了更广阔的视野。本文综述了巨噬细胞先天免疫记忆的性质、机制及其在疾病中的意义。
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Advances in innate immune memory of macrophages
Immunity is usually classified into two categories: innate immunity and adaptive immunity, distinguished by the process and characteristics of the immunological impact. It was widely assumed that only adaptive immunity possessed memory features; however, current research has revealed that innate immunity, like adaptive immunity, possesses memory properties as well. “Trained immunity”, also known as “innate immune memory”, is a phenomenon that occurs when the immune system’s innate cells are stimulated and then undergo epigenetic reprogramming and metabolic alterations. When it comes to innate immunity, macrophages are essential since they have immunological memory capabilities and play a significant role in the body’s immunity. The concept of innate immune memory expands the definition of immunological memory and offers a broader view of immune response research. This article reviews the properties, mechanism, and significance of macrophage innate immune memory in disease.
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