微埃克森:转录组的新型调节因子

Ashton Curry-Hyde, Bei Jun Chen, J. D. Mills, M. Janitz
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引用次数: 8

摘要

摘要RNA的选择性剪接是一个基本的转录后调控过程,它导致从相对较少的基因组基因座翻译出大量多样的蛋白质。微埃克森是一组由1-17个氨基酸组成的非常小的蛋白质编码序列,直到最近才被认为是前信使核糖核酸加工的重要组成部分。最近的研究表明,微栓子在各种细胞功能、蛋白质-蛋白质相互作用中发挥着重要作用,也与各种神经疾病有关。这篇综述提供了关于微栓子对细胞和疾病生物学的功能影响以及其剪接调控机制的最新研究。最后,讨论了目前检测微栓子的生物信息学方法。
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Microexons: novel regulators of the transcriptome
Abstract Alternative splicing of RNA is a fundamental post-transcriptional regulatory process that leads to a vast diversity of proteins being translated from a relatively small number of genomic loci. Microexons, a set of very small protein-coding sequences of 1-17 amino acids, have only recently been recognised as an important part of pre-mRNA processing. Recent studies have revealed that microexons can play important roles in various cellular functions, protein-protein interactions and have also been associated with various neurological diseases. This review provides an update on research covering the functional impact of microexons on the biology of a cell and disease, and the mechanisms by which their splicing is regulated. Finally, the current bioinformatics methods for detecting microexons are discussed.
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Microexons: novel regulators of the transcriptome Conservation and tissue-specific transcription patterns of long noncoding RNAs. Welcome message from the Editor-in-Chief
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