Zeinah Al-Darsani, David R Jacobs, R Nick Bryan, Lenore J Launer, Lyn M Steffen, Kristine Yaffe, James M Shikany, Andrew O Odegaard
{"title":"根据年轻人和中年人的平均改良地中海饮食评分测量中年MRI脑生物标志物","authors":"Zeinah Al-Darsani, David R Jacobs, R Nick Bryan, Lenore J Launer, Lyn M Steffen, Kristine Yaffe, James M Shikany, Andrew O Odegaard","doi":"10.3233/NHA-220192","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The Mediterranean diet (MedDiet) has been linked with better cognitive function and brain integrity.</p><p><strong>Objective: </strong>To examine the association of modified Mediterranean diet (mMedDiet) scores from early through middle adulthood in relation to volumetric and microstructural midlife MRI brain measures. Assess the association of mMedDiet and brain measures with four cognitive domains. If variables are correlated, determine if brain measures mediate the relationship between mMedDiet and cognition.</p><p><strong>Methods: </strong>618 participants (mean age 25.4±3.5 at year 0) of the Coronary Artery Risk Development in Young Adults (CARDIA) study were included. Cumulative average mMedDiet scores were calculated by averaging scores from years 0, 7, and 20. MRI scans were obtained at years 25 and 30. General linear models were used to examine the association between mMedDiet and brain measures.</p><p><strong>Results: </strong>Higher cumulative average mMedDiet scores were associated with better microstructural white matter (WM) integrity measured by fractional anisotropy (FA) at years 25 and 30 (all p<sub>trend</sub> <0.05). Higher mMedDiet scores at year 7 were associated with higher WM FA at year 25 (β= 0.003, p<sub>trend</sub> = 0.03). Higher mMedDiet scores at year 20 associated with higher WM FA at years 25 (β= 0.0005, p<sub>trend</sub> = 0.002) and 30 (β= 0.0003, p<sub>trend</sub> = 0.02). mMedDiet scores were not associated with brain volumes. Higher mMedDiet scores and WM FA were both correlated with better executive function, processing speed, and global cognition (all p<sub>trend</sub> <0.05). WM FA did not mediate the association between mMedDiet scores and cognition.</p><p><strong>Conclusions: </strong>mMedDiet scores may be associated with microstructural WM integrity at midlife.</p>","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"8 1","pages":"109-121"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475985/pdf/","citationCount":"0","resultStr":"{\"title\":\"Measures of MRI Brain Biomarkers in Middle Age According to Average Modified Mediterranean Diet Scores Throughout Young and Middle Adulthood.\",\"authors\":\"Zeinah Al-Darsani, David R Jacobs, R Nick Bryan, Lenore J Launer, Lyn M Steffen, Kristine Yaffe, James M Shikany, Andrew O Odegaard\",\"doi\":\"10.3233/NHA-220192\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The Mediterranean diet (MedDiet) has been linked with better cognitive function and brain integrity.</p><p><strong>Objective: </strong>To examine the association of modified Mediterranean diet (mMedDiet) scores from early through middle adulthood in relation to volumetric and microstructural midlife MRI brain measures. Assess the association of mMedDiet and brain measures with four cognitive domains. If variables are correlated, determine if brain measures mediate the relationship between mMedDiet and cognition.</p><p><strong>Methods: </strong>618 participants (mean age 25.4±3.5 at year 0) of the Coronary Artery Risk Development in Young Adults (CARDIA) study were included. Cumulative average mMedDiet scores were calculated by averaging scores from years 0, 7, and 20. MRI scans were obtained at years 25 and 30. General linear models were used to examine the association between mMedDiet and brain measures.</p><p><strong>Results: </strong>Higher cumulative average mMedDiet scores were associated with better microstructural white matter (WM) integrity measured by fractional anisotropy (FA) at years 25 and 30 (all p<sub>trend</sub> <0.05). Higher mMedDiet scores at year 7 were associated with higher WM FA at year 25 (β= 0.003, p<sub>trend</sub> = 0.03). Higher mMedDiet scores at year 20 associated with higher WM FA at years 25 (β= 0.0005, p<sub>trend</sub> = 0.002) and 30 (β= 0.0003, p<sub>trend</sub> = 0.02). mMedDiet scores were not associated with brain volumes. Higher mMedDiet scores and WM FA were both correlated with better executive function, processing speed, and global cognition (all p<sub>trend</sub> <0.05). WM FA did not mediate the association between mMedDiet scores and cognition.</p><p><strong>Conclusions: </strong>mMedDiet scores may be associated with microstructural WM integrity at midlife.</p>\",\"PeriodicalId\":37419,\"journal\":{\"name\":\"Nutrition and Healthy Aging\",\"volume\":\"8 1\",\"pages\":\"109-121\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10475985/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition and Healthy Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3233/NHA-220192\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition and Healthy Aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/NHA-220192","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Measures of MRI Brain Biomarkers in Middle Age According to Average Modified Mediterranean Diet Scores Throughout Young and Middle Adulthood.
Background: The Mediterranean diet (MedDiet) has been linked with better cognitive function and brain integrity.
Objective: To examine the association of modified Mediterranean diet (mMedDiet) scores from early through middle adulthood in relation to volumetric and microstructural midlife MRI brain measures. Assess the association of mMedDiet and brain measures with four cognitive domains. If variables are correlated, determine if brain measures mediate the relationship between mMedDiet and cognition.
Methods: 618 participants (mean age 25.4±3.5 at year 0) of the Coronary Artery Risk Development in Young Adults (CARDIA) study were included. Cumulative average mMedDiet scores were calculated by averaging scores from years 0, 7, and 20. MRI scans were obtained at years 25 and 30. General linear models were used to examine the association between mMedDiet and brain measures.
Results: Higher cumulative average mMedDiet scores were associated with better microstructural white matter (WM) integrity measured by fractional anisotropy (FA) at years 25 and 30 (all ptrend <0.05). Higher mMedDiet scores at year 7 were associated with higher WM FA at year 25 (β= 0.003, ptrend = 0.03). Higher mMedDiet scores at year 20 associated with higher WM FA at years 25 (β= 0.0005, ptrend = 0.002) and 30 (β= 0.0003, ptrend = 0.02). mMedDiet scores were not associated with brain volumes. Higher mMedDiet scores and WM FA were both correlated with better executive function, processing speed, and global cognition (all ptrend <0.05). WM FA did not mediate the association between mMedDiet scores and cognition.
Conclusions: mMedDiet scores may be associated with microstructural WM integrity at midlife.
期刊介绍：
Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.
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