甲状腺功能减退对结肠癌大鼠血液性激素水平及肿瘤内激素含量的影响

O. Kit, V. Bandovkina, E. Frantsiyants, I. Kaplieva, A. Shikhlyarova, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, L. K. Trepitaki, A. Arakelova, N. Maksimova, Yury A. Poryvaev, M. Ilchenko, V. Irina, Kaplieva, Irina V. Nesku, Lidia K. Trepit
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On the 18th day of the tumor growth, the animals were sacrificed, and, using standard RIA kits, in the serum, the tumor homogenates and the perifocal zone, the levels of estradiol (E2), testosterone (T) and progesterone (P4) were determined. Results. In comparison with intact animals, hypothyroidism caused an increase in the blood content of E2 in animals of both sexes by 2.2-2.4 times and T by 1.4-16 times, and P4 by 1.7 times only in females, but recorded was a decrease therein in males by 2.4 times. The growth of Guerin’s carcinoma resulted in a 2.5-5.5-fold decrease in E2 in blood of the animals of both sexes, an increase in T by 2.1 times and P4 by 3 times in the females, but a decrease in T by 2.6 times without changing P4 in the males. In the main group, in the animals of both sexes, similarly to the processes in hypothyroidism, the level of E2 and P4 increased by 1.4-1.6 times, and in females also T by 4.4 times, compared with the intact animals. Conclusion. 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引用次数: 0

摘要

我们研究工作的目的是在甲状腺功能减退的背景下,研究患有格林氏癌的两性大鼠的血液、肿瘤和病灶周围区域中性类固醇的水平。材料和方法。实验在110只雄性和雌性大鼠中进行。甲唑醇药物诱导动物甲状腺功能减退30天,然后移植Guerin’s癌(主要组)。参考组包括独立生长的格林氏癌和独立甲状腺功能减退的动物,以及完整的动物(正常)。在肿瘤生长的第18天,处死动物,并使用标准RIA试剂盒,在血清、肿瘤匀浆和病灶周围区中测定雌二醇(E2)、睾酮(T)和孕酮(P4)的水平。后果与完整的动物相比,甲状腺功能减退症导致两性动物的E2血液含量增加了2.2-2.4倍,T血液含量增加1.4-16倍,P4血液含量仅在雌性动物中增加了1.7倍,但雄性动物的血液含量减少了2.4倍。Guerin’s癌的生长导致两性动物血液中E2减少2.5-5.5倍,雌性动物T增加2.1倍,P4增加3倍,但雄性动物T减少2.6倍,而P4没有改变。在主要组中,在两性动物中,与甲状腺功能减退症的过程类似,与完整动物相比,E2和P4水平增加了1.4-1.6倍,雌性动物的T水平也增加了4.4倍。结论甲状腺功能减退和格林氏癌的生长使两性动物的E2向不同方向变化,血液中性激素水平改变,并改变了肿瘤及其局灶周围区域的类固醇平衡。在主要组的女性中,雌激素、雄激素和孕酮的肿瘤饱和度降低,而在男性中,相反,类固醇的浓度增加。
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Influence by hypothyroidism on the level of sex hormones in blood and their intracrine content in the tumor in rats with Guerin’s carcinoma
The aim of our research work was to study the level of sex steroids in blood, the tumor and the perifocal zone in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. The experiment was performed in 110 outbred rats of both sexes. Hypothyroidism was induced in animals for 30 days with Mercazolil medication, and then Guerin’s carcinoma was transplanted (the main group). The reference groups included animals with an independent growth of Guerin’s carcinoma and with independent hypothyroidism, as well as intact animals (the norm). On the 18th day of the tumor growth, the animals were sacrificed, and, using standard RIA kits, in the serum, the tumor homogenates and the perifocal zone, the levels of estradiol (E2), testosterone (T) and progesterone (P4) were determined. Results. In comparison with intact animals, hypothyroidism caused an increase in the blood content of E2 in animals of both sexes by 2.2-2.4 times and T by 1.4-16 times, and P4 by 1.7 times only in females, but recorded was a decrease therein in males by 2.4 times. The growth of Guerin’s carcinoma resulted in a 2.5-5.5-fold decrease in E2 in blood of the animals of both sexes, an increase in T by 2.1 times and P4 by 3 times in the females, but a decrease in T by 2.6 times without changing P4 in the males. In the main group, in the animals of both sexes, similarly to the processes in hypothyroidism, the level of E2 and P4 increased by 1.4-1.6 times, and in females also T by 4.4 times, compared with the intact animals. Conclusion. Hypothyroidism and the growth of Guerin’s carcinoma changed E2 in different directions in animals of both sexes the level of sex hormones in blood and shifted the steroid balance in the tumor and its perifocal zone. In the females of the main group, the saturation of the tumor with estrogens, androgens and progesterone decreased, while in the males, on the contrary, the concentration of steroids increased.
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来源期刊
Cardiometry
Cardiometry MEDICAL LABORATORY TECHNOLOGY-
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期刊介绍: Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.
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