Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.4753
E. Brodovskaya, A. Dombrovskaya, I.D. Kravchuk, E. V. Likhacheva, V. Lukushin, L. P. Nikolaeva, A. S. Ognev, R.V. Parma
The article presents the experimental confirmation of the hypothesis that with the help of cardio- and oculometric attestation of various types of visual content, it is possible to conduct a selective analysis of the stimulus material used in projective diagnostics and to identify a group of images most suitable for operative counseling, and also shows that there is often an increased interest in content that symbolizes the value of rivalry and risky forms of behavior, with a high degree of probability, will correlate with the rapid manifestation of the respondent's dissatisfaction with various kinds of restrictions on their own behavior.
{"title":"Cardiometric assessment of visual stimuli to identify likely reactions to destructive network content","authors":"E. Brodovskaya, A. Dombrovskaya, I.D. Kravchuk, E. V. Likhacheva, V. Lukushin, L. P. Nikolaeva, A. S. Ognev, R.V. Parma","doi":"10.18137/cardiometry.2023.29.4753","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.4753","url":null,"abstract":"The article presents the experimental confirmation of the hypothesis that with the help of cardio- and oculometric attestation of various types of visual content, it is possible to conduct a selective analysis of the stimulus material used in projective diagnostics and to identify a group of images most suitable for operative counseling, and also shows that there is often an increased interest in content that symbolizes the value of rivalry and risky forms of behavior, with a high degree of probability, will correlate with the rapid manifestation of the respondent's dissatisfaction with various kinds of restrictions on their own behavior.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
With the participation of 8 male volunteers, the dynamics of values of heart rate autonomic regulation were studied at response to physical load on a bicycle ergometer twice: both respirating by the room air under normobaric environment and simulating effects of the altered hyperoxic respiratory gas mixture (HRGM) by the rebreathe respiration methods from a rebreather at the high-pressure chamber (at «depth» 7 m). The devices and methods of Holter electrocardiogram monitoring were used under 24 hours research. The specialized software to analyze the data was used. The electrocardiogram (ECG) and calculated time series of cardiac intervals data obtained were subjected to mathematical processing to calculate statistical and spectral values of heart rate variability (HRV). Additionally, the geometric and nonlinear analysis methods of HRV were investigated. It has been established that influencing factors (compound and pressure of the HRGM) affect the autonomic regulation of heartbeats both at rest and during physical load. Clinical practitioners the HRV values are studied at rest and during strictly regulated tests, i.e. in stationary conditions. The analysis of non-stationary processes, for example, when it is necessary to continuously analyze data, the so-called transient processes under increasing psychological stress, to assess changes in the autonomic regulation of the heart during breathing of gas mixtures with different compositions (hypoxic therapy, hyperbaric oxygenation, etc.), and, especially during physically upload are used the methods of nonlinear and geometric analysis of HRV that are independent of the degree of nonstationary processes and, to some extent, of artifactual cardiac intervals. During the breathing the respiratory gas mixtures with an increased substance of O2 under conditions of high pressure, the activity of the parasympathetic branches of the autonomic nervous system (ANS) significantly increases. The nonlinear dynamics indexes reflect significant differences in the activity of autonomic components under experimental conditions in the direction of strengthening the parasympathetic links of the ANS. The use of nonlinear analysis values is more acceptable when evaluating obtained of non-stationary processes. In general, the study confirms that the regulatory response to the effects of hyperbaria and hyperoxia when performing a bicycle ergometer test with stepwise increase exercise strain is manifested by the prevalence of the activity of the parasympathetic part of the ANS autonomic regulation of cardiac rhythm compared to regular room air and barometric pressure.
{"title":"The influence of combined effects of hyperbaria and hyperoxia on human heart rate variability during exercise strain","authors":"Е.Yu. Bersenev, A.I. Dyachenko, A.V. Suvorov, P.N. Demina, I. Berseneva, T.V. Dyachkova","doi":"10.18137/cardiometry.2023.29.8089","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.8089","url":null,"abstract":"With the participation of 8 male volunteers, the dynamics of values of heart rate autonomic regulation were studied at response to physical load on a bicycle ergometer twice: both respirating by the room air under normobaric environment and simulating effects of the altered hyperoxic respiratory gas mixture (HRGM) by the rebreathe respiration methods from a rebreather at the high-pressure chamber (at «depth» 7 m). The devices and methods of Holter electrocardiogram monitoring were used under 24 hours research. The specialized software to analyze the data was used. The electrocardiogram (ECG) and calculated time series of cardiac intervals data obtained were subjected to mathematical processing to calculate statistical and spectral values of heart rate variability (HRV). Additionally, the geometric and nonlinear analysis methods of HRV were investigated. It has been established that influencing factors (compound and pressure of the HRGM) affect the autonomic regulation of heartbeats both at rest and during physical load. Clinical practitioners the HRV values are studied at rest and during strictly regulated tests, i.e. in stationary conditions. The analysis of non-stationary processes, for example, when it is necessary to continuously analyze data, the so-called transient processes under increasing psychological stress, to assess changes in the autonomic regulation of the heart during breathing of gas mixtures with different compositions (hypoxic therapy, hyperbaric oxygenation, etc.), and, especially during physically upload are used the methods of nonlinear and geometric analysis of HRV that are independent of the degree of nonstationary processes and, to some extent, of artifactual cardiac intervals. During the breathing the respiratory gas mixtures with an increased substance of O2 under conditions of high pressure, the activity of the parasympathetic branches of the autonomic nervous system (ANS) significantly increases. The nonlinear dynamics indexes reflect significant differences in the activity of autonomic components under experimental conditions in the direction of strengthening the parasympathetic links of the ANS. The use of nonlinear analysis values is more acceptable when evaluating obtained of non-stationary processes. In general, the study confirms that the regulatory response to the effects of hyperbaria and hyperoxia when performing a bicycle ergometer test with stepwise increase exercise strain is manifested by the prevalence of the activity of the parasympathetic part of the ANS autonomic regulation of cardiac rhythm compared to regular room air and barometric pressure.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.9094
F.F. Muhammad, R.F. Tayyab, M. Sana, Y. Usama
To know the effect of Diabetes type-II on Eye disease and its risk factors in a tertiary eye care hospital in Karachi. This was a cross-sectional study with retrospective data collection. The data was retrieved from January to June 2019 from the Hospital Information Management System (HIMS) software of the Institute. Non-probability purposive sampling method was used to collect data. Inclusion criteria were all the diabetics type-II patients came for routine check-ups at Diabetes Eye Department irrespective of age, gender and duration of diabetes. Statistical analysis was done using STATA version 13.0 software for windows. A total of 6090 cases were analyzed. Mean age of the participants was 51.01±10.8 years. There were 2954 (48.5%) male and 3136 (51.5%) female observed in this study. Table 1 shows the results of the binary logistic regression analysis with coefficients and their standard errors (S.E.), Wald test values, p values, odd ratios, and 95% confidence intervals for odds ratios. When all explanatory variables treat as continuous variables, we found that all variables which include age, height, random blood sugar (RBS) and duration of diabetes was statistically significant at the significance level 0.05 except weight and fasting blood sugar (FBS) for individual regression slope coefficients. This study reveals findings through binary logistics regression analysis. It indicates that there is an association found in the patients of eye disease with age, height, weight, RBS, FBS. This stated that there were some risk factors observed in these variables related to eye disease. Those who have the disease have risk factor to developed the others associated disease.
{"title":"Effect of Diabetes type-II on Eye disease and its risk factors; A Logit Model Analysis","authors":"F.F. Muhammad, R.F. Tayyab, M. Sana, Y. Usama","doi":"10.18137/cardiometry.2023.29.9094","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.9094","url":null,"abstract":"To know the effect of Diabetes type-II on Eye disease and its risk factors in a tertiary eye care hospital in Karachi. This was a cross-sectional study with retrospective data collection. The data was retrieved from January to June 2019 from the Hospital Information Management System (HIMS) software of the Institute. Non-probability purposive sampling method was used to collect data. Inclusion criteria were all the diabetics type-II patients came for routine check-ups at Diabetes Eye Department irrespective of age, gender and duration of diabetes. Statistical analysis was done using STATA version 13.0 software for windows. A total of 6090 cases were analyzed. Mean age of the participants was 51.01±10.8 years. There were 2954 (48.5%) male and 3136 (51.5%) female observed in this study. Table 1 shows the results of the binary logistic regression analysis with coefficients and their standard errors (S.E.), Wald test values, p values, odd ratios, and 95% confidence intervals for odds ratios. When all explanatory variables treat as continuous variables, we found that all variables which include age, height, random blood sugar (RBS) and duration of diabetes was statistically significant at the significance level 0.05 except weight and fasting blood sugar (FBS) for individual regression slope coefficients. This study reveals findings through binary logistics regression analysis. It indicates that there is an association found in the patients of eye disease with age, height, weight, RBS, FBS. This stated that there were some risk factors observed in these variables related to eye disease. Those who have the disease have risk factor to developed the others associated disease.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139299372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.21
G. M. Salieva, A. Kubyshkin, I. Fomochkina, A.V. Kamysheva
The etiology of hereditary ovarian cancer is most often attributed to structural or functional inactivation of some tumor suppressors. An identification of the molecular genetic basis of the disease has prognostic significance, and it also influences the selection of the most effective therapeutic tactics. The rate of the occurrence of polymorphisms is variable and depends, among other things, on ethnicity and geography.
{"title":"MOLECULAR GENETIC CHARACTERISTICS OF OVARIAN CANCER IN CRIMEAN PATIENTS","authors":"G. M. Salieva, A. Kubyshkin, I. Fomochkina, A.V. Kamysheva","doi":"10.18137/cardiometry.2023.29.conf.21","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.21","url":null,"abstract":"The etiology of hereditary ovarian cancer is most often attributed to structural or functional inactivation of some tumor suppressors. An identification of the molecular genetic basis of the disease has prognostic significance, and it also influences the selection of the most effective therapeutic tactics. The rate of the occurrence of polymorphisms is variable and depends, among other things, on ethnicity and geography.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.16
M. Lukashina, M.D. Mollaev, A. Posvyatenko, A.V. Kibardin, M.A. Maschan, S. S. Larin
The process of transferring the technology for obtaining a drug from the laboratory to production and, then, to the clinical practice is always a very complicated and time-consuming way, requiring many adaptation solutions. Regarding biomedical cell products (BMCP), this is even a more complex process, requiring large-scale expansion of procedures to obtain clinically significant numbers of cells, adaptation to reagents and equipment, and establishment of safety parameters for reagents, equipment and the final product. Nevertheless, cell therapy has become an integral part of treatment regimens for malignant neoplasms. Today, thousands of studies of BMCP are being conducted around the world, both in mono-regimen and in various regimen combinations.
{"title":"QUALITY CONTROL OF NK CELLS PRODUCED EX VIVO FOR MALIGNANT NEOPLASM THERAPY","authors":"M. Lukashina, M.D. Mollaev, A. Posvyatenko, A.V. Kibardin, M.A. Maschan, S. S. Larin","doi":"10.18137/cardiometry.2023.29.conf.16","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.16","url":null,"abstract":"The process of transferring the technology for obtaining a drug from the laboratory to production and, then, to the clinical practice is always a very complicated and time-consuming way, requiring many adaptation solutions. Regarding biomedical cell products (BMCP), this is even a more complex process, requiring large-scale expansion of procedures to obtain clinically significant numbers of cells, adaptation to reagents and equipment, and establishment of safety parameters for reagents, equipment and the final product. Nevertheless, cell therapy has become an integral part of treatment regimens for malignant neoplasms. Today, thousands of studies of BMCP are being conducted around the world, both in mono-regimen and in various regimen combinations.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.3
U. A. Bokova, M. Tretyakova, A.A. Frolova, V. Alifanov, E. S. Andryukhova, N. Cherdyntseva, V. Perelmuter, E. Denisov
To study the mechanisms of metastasis, one of the effective tools is mouse models using primary patient tumors (Patient-Derived Xenograft, PDX). The phenomenon of changes in the cell phenotype in response to the dynamic conditions of the tumor microenvironment is one of the key processes forming the basis for metastasis.
{"title":"PHENOTYPIC COMPOSITION OF TUMOR CELLS AND THEIR ROLE IN THE PROCESS OF METASTASIS WHEN DEVELOPING A PDX MODEL OF BREAST CANCER","authors":"U. A. Bokova, M. Tretyakova, A.A. Frolova, V. Alifanov, E. S. Andryukhova, N. Cherdyntseva, V. Perelmuter, E. Denisov","doi":"10.18137/cardiometry.2023.29.conf.3","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.3","url":null,"abstract":"To study the mechanisms of metastasis, one of the effective tools is mouse models using primary patient tumors (Patient-Derived Xenograft, PDX). The phenomenon of changes in the cell phenotype in response to the dynamic conditions of the tumor microenvironment is one of the key processes forming the basis for metastasis.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139293443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.25
M. Tsyganov, E.O. Rodionov, M. Ibragimova, S. S. Sorokovikova, A. A. Karchevskaya
Numerous studies have shown that the presence of homologous recombination deficiency (HRD) in breast tumors may be a good marker of the effectiveness of chemotherapy with DNA-damaging agents such as platinum-based and anthracycline-containing medication regimens. However, the formation of HRD due to disruptions in the BRCA1/2 genes is typical not only for breast cancer and ovarian cancer, but also for other cancer localizations, in particular for non-small cell lung cancer (NSCLC). Since the use of platinum-based drugs in patients with NSCLC is a standard treatment protocol, studying the expression profile of homologous recombination genes and the presence of chromosomal aberrations therein will allow us to fully study HRD in these patients and identify new prognostic markers.
{"title":"ASSESSMENT OF THE PROGNOSTIC POTENTIAL OF EXPRESSION AND ABERRATIONS IN THE NUMBER OF DNA COPIES OF THE HOMOLOGICAL RECOMBINATION SYSTEM GENES IN PATIENTS WITH NON-SMALL CELL LUNG CANCER","authors":"M. Tsyganov, E.O. Rodionov, M. Ibragimova, S. S. Sorokovikova, A. A. Karchevskaya","doi":"10.18137/cardiometry.2023.29.conf.25","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.25","url":null,"abstract":"Numerous studies have shown that the presence of homologous recombination deficiency (HRD) in breast tumors may be a good marker of the effectiveness of chemotherapy with DNA-damaging agents such as platinum-based and anthracycline-containing medication regimens. However, the formation of HRD due to disruptions in the BRCA1/2 genes is typical not only for breast cancer and ovarian cancer, but also for other cancer localizations, in particular for non-small cell lung cancer (NSCLC). Since the use of platinum-based drugs in patients with NSCLC is a standard treatment protocol, studying the expression profile of homologous recombination genes and the presence of chromosomal aberrations therein will allow us to fully study HRD in these patients and identify new prognostic markers.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.5
N.B. Fadeev, N. I. Sidelnikov
The aim of our study was to search and identify new promising plant species containing alkaloids in order to develop new effective herbal medicines for antitumor therapy.
我们研究的目的是寻找和鉴定含有生物碱的新的有前途的植物物种，以开发新的有效的抗肿瘤草药。
{"title":"MEDICINAL PLANTS CONTAINING ALKALOIDS: PROSPECTS FOR THEIR USE IN ONCOLOGY","authors":"N.B. Fadeev, N. I. Sidelnikov","doi":"10.18137/cardiometry.2023.29.conf.5","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.5","url":null,"abstract":"The aim of our study was to search and identify new promising plant species containing alkaloids in order to develop new effective herbal medicines for antitumor therapy.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.4046
V.O. Chereshnev, S.G. Proskurin
The results of a study of a series of sequential images of a vessel and a hydrodynamic phantom of biological tissues obtained using a Spectral Domain Optical Coherence Tomography (SP OCT) are presented. Acquired data were processed and histograms of speckle distributions were created. They demonstrated differences in the intensity distribution for three different areas of the OCT image: (1) free space, (2) wall of the vessel, and (3) the flow of scatterers. Using an optimization algorithm the histograms were approximated by various distribution functions, best result was demonstrated by the beta distribution with the determination coefficient R2 ~ 0.95. The resulting distributions quantitatively demonstrate effect of tissue heterogeneity. They show significant differences in the values of the shape and scale parameters, corresponding to the obtained beta distribution parameters, which were α ~ 1.7, β ~ 20.5 for free space, α ~ 3.1, β ~ 5.5 for the wall region of the phantom, α ~ 2.6, β ~ 1.7 for the flow of the scattering liquid. Variance matrices of the OCT images, which show correlation of speckles between adjacent pixels and those of the successive images were also obtained. Brighter areas of the variance matrix indicate a dynamic speckle structure in OCT images, while low brightness of the areas indicates static speckle structure, on the contrary.
本文介绍了使用光谱域光学相干断层扫描（SP OCT）获得的一系列血管和生物组织流体力学模型连续图像的研究结果。对获取的数据进行了处理，并绘制了斑点分布直方图。它们显示了 OCT 图像三个不同区域的强度分布差异：(1) 自由空间，(2) 血管壁，(3) 散射体流。他们使用优化算法，用各种分布函数对直方图进行了近似处理，结果表明贝塔分布的效果最好，确定系数 R2 ~ 0.95。结果分布定量地显示了组织异质性的影响。它们在形状参数和比例参数值上显示出明显的差异，与所获得的贝塔分布参数相对应，自由空间为 α ~ 1.7，β ~ 20.5；模型壁区域为 α ~ 3.1，β ~ 5.5；散射液体流为 α ~ 2.6，β ~ 1.7。此外，还获得了 OCT 图像的方差矩阵，该矩阵显示了相邻像素间斑点的相关性以及连续图像中斑点的相关性。方差矩阵中亮度较高的区域表示 OCT 图像中的动态斑点结构，而亮度较低的区域则表示静态斑点结构。
{"title":"SPECKLE IMAGES OF THE VESSELS AND HYDRODYNAMIC PHANTOMS IN OPTICAL COHERENCE TOMOGRAPHY","authors":"V.O. Chereshnev, S.G. Proskurin","doi":"10.18137/cardiometry.2023.29.4046","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.4046","url":null,"abstract":"The results of a study of a series of sequential images of a vessel and a hydrodynamic phantom of biological tissues obtained using a Spectral Domain Optical Coherence Tomography (SP OCT) are presented. Acquired data were processed and histograms of speckle distributions were created. They demonstrated differences in the intensity distribution for three different areas of the OCT image: (1) free space, (2) wall of the vessel, and (3) the flow of scatterers. Using an optimization algorithm the histograms were approximated by various distribution functions, best result was demonstrated by the beta distribution with the determination coefficient R2 ~ 0.95. The resulting distributions quantitatively demonstrate effect of tissue heterogeneity. They show significant differences in the values of the shape and scale parameters, corresponding to the obtained beta distribution parameters, which were α ~ 1.7, β ~ 20.5 for free space, α ~ 3.1, β ~ 5.5 for the wall region of the phantom, α ~ 2.6, β ~ 1.7 for the flow of the scattering liquid. Variance matrices of the OCT images, which show correlation of speckles between adjacent pixels and those of the successive images were also obtained. Brighter areas of the variance matrix indicate a dynamic speckle structure in OCT images, while low brightness of the areas indicates static speckle structure, on the contrary.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.18137/cardiometry.2023.29.conf.2
O. Bocharova, R. Karpova, E. Bocharov, A.A. Aksenov, V. Kucheryanu
The concept that the key mechanism of the tumor process is the disruption of adhesive interactions is based on the participation of local, general and central mechanisms.
肿瘤过程的关键机制是粘附相互作用的破坏，这一概念的基础是局部、总体和中央机制的参与。
{"title":"TUMOR GROWTH ADHESION","authors":"O. Bocharova, R. Karpova, E. Bocharov, A.A. Aksenov, V. Kucheryanu","doi":"10.18137/cardiometry.2023.29.conf.2","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.29.conf.2","url":null,"abstract":"The concept that the key mechanism of the tumor process is the disruption of adhesive interactions is based on the participation of local, general and central mechanisms.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139300968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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