Ayca Circir Hatil, Esra Çiçek, Merve Oyken, A. E. Erson-Bensan
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引用次数: 0
摘要
ERBB家族成员表皮受体酪氨酸激酶(EGFR)由28个外显子和27个内含子组成。EGFR编码11个转录本，其中8个为蛋白质编码。EGFR是一种跨膜糖蛋白，可以被几种不同的配体激活，如表皮生长因子(EGF)、转化生长因子- α (TGFA)、肝素结合的EGF样生长因子(HBEGF)、β -纤维素蛋白(BTC)、双调节蛋白(AREG)、表调节蛋白(EREG)和表原(EPGN) (Singh, 2016)。配体结合诱导EGFR二聚化和自磷酸化，随后是一系列下游磷酸化事件(Capuani et al.， 2015)。EGFR激活在细胞存活、增殖、迁移和分化中起着关键作用(Purba, 2017)。
ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN) (Singh, 2016). Ligand binding induces the dimerization of EGFR and autophosphorylation followed by a cascade of downstream phosphorylation events (Capuani et al., 2015). EGFR activation plays a key role in cell survival, proliferation, migration and differentiation (Purba, 2017).
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