有无妊娠期糖尿病足月新生儿QT离散度与超声心动图指标是否相关?

M. Zarkesh, Seyyedeh Azade Hoseini Nouri, Manijeh Tabrizi, Esfandiar Nazari, Atbin Latifi, Sadroddin Mahdipour, E. Kazemnezhad leili
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Ejection fraction (EF), interventricular septal thickness at the end of diastole (IVSTD), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), and left ventricular posterior wall thickness (LVPWT) were evaluated by performing echocardiography, and the two groups were compared regarding them. Data were analyzed using SPSS version 21. Results: In this study, neonates' mean age and weight were 4.18 ± 1.3 days and 3418.16 ± 549.24 grams, respectively. As for the gender of neonates, 68.4% in the case group and 47.4% in the control group were female. The two groups had no significant difference regarding age, weight, and sex (P > 0.05). Minimum QTc (QTc min) was significantly higher in the case group (P = 0.046). Considerably lower EF and higher IVSTD were found in the case group (P = 0.011 and P = 0.05 respectively). 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引用次数: 0

摘要

背景:妊娠期糖尿病(GDM)可导致妊娠期糖尿病母亲(igdm)的婴儿舒张功能障碍和不对称室间隔肥厚。心室厚度可影响QT间期及其他QT参数。目的:本研究旨在评估和比较两组有和无GDM母亲的新生儿QT间期、校正QT间期(QTc)、QT离散度(QTD)和超声心动图指标。方法:本病例对照研究纳入76例足月新生儿。病例组(n = 38)包括IGDM,对照组(n = 38)包括健康母亲所生的新生儿。根据心电图结果计算QT、QTD和QTc。采用超声心动图评价两组患者的射血分数(EF)、舒张末期室间隔厚度(IVSTD)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室后壁厚度(LVPWT),并进行比较。数据采用SPSS version 21进行分析。结果:本组新生儿平均年龄为4.18±1.3 d,体重为3418.16±549.24 g。新生儿性别方面,病例组为68.4%,对照组为47.4%。两组患者年龄、体重、性别差异无统计学意义(P < 0.05)。病例组最小QTc (QTc min)显著高于病例组(P = 0.046)。病例组EF明显降低,IVSTD明显升高(P = 0.011, P = 0.05)。单因素分析中,超声心动图参数不是QTD的预测因子(P < 0.05);然而,在多变量分析中,QTD与LVEDD (P = 0.001)和LVESD (P = 0.015)显著相关。结论:与健康母亲的婴儿相比,igdm婴儿中隔肥厚的比例更高,与ECG指标无相关性。超声心动图证实,这种受累伴有相对降低的EF。除LVEDD和LVESD外,大多数心电图表现(包括QTD值)与超声心动图参数无线性关系。
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Is There Any Correlation Between QT Dispersion and Echocardiographic Indices in Term Neonates with and Without Maternal Gestational Diabetes Mellitus?
Background: Gestational diabetes mellitus (GDM) can cause diastolic dysfunction and asymmetric ventricular septal hypertrophy in infants of gestational diabetic mothers (IGDMs). Ventricular thickness can affect QT interval and other QT parameters. Objectives: This study aimed to evaluate and compare the duration of QT, corrected QT (QTc), QT dispersion (QTD), and echocardiographic indices in two groups of neonates of mothers with and without GDM. Methods: In this case-control study, 76 term neonates were enrolled. The case group (n = 38) included IGDM, and the control group (n = 38) included neonates born to healthy mothers. The QT, QTD, and QTc were calculated based on electrocardiographic results. Ejection fraction (EF), interventricular septal thickness at the end of diastole (IVSTD), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), and left ventricular posterior wall thickness (LVPWT) were evaluated by performing echocardiography, and the two groups were compared regarding them. Data were analyzed using SPSS version 21. Results: In this study, neonates' mean age and weight were 4.18 ± 1.3 days and 3418.16 ± 549.24 grams, respectively. As for the gender of neonates, 68.4% in the case group and 47.4% in the control group were female. The two groups had no significant difference regarding age, weight, and sex (P > 0.05). Minimum QTc (QTc min) was significantly higher in the case group (P = 0.046). Considerably lower EF and higher IVSTD were found in the case group (P = 0.011 and P = 0.05 respectively). In univariate analysis, echocardiographic parameters were not the predictors of QTD (P > 0.05); in multivariate analysis, however, QTD was significantly correlated with LVEDD (P = 0.001) and LVESD (P = 0.015). Conclusions: A higher proportion of septal hypertrophy was detected in IGDMs compared to infants of the healthy mothers without any correlation with ECG indices. This involvement was accompanied by relatively decreased EF verified by echocardiography. Most ECG findings, including QTD values, had no linear relationship with echocardiographic parameters except for LVEDD and LVESD.
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来源期刊
Journal of Comprehensive Pediatrics
Journal of Comprehensive Pediatrics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
0.90
自引率
0.00%
发文量
28
期刊介绍: Journal of Comprehensive Pediatrics is the official publication of Iranian Society of Pediatrics (ISP) and a peer-reviewed medical journal which is published quarterly. It is informative for all practicing pediatrics including general medical profession.
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