Systemic inflammation response index and systemic immune inflammation index for predicting acute cholecystitis

Objective: Acute cholecystitis (AC) is a condition caused by acute inflammation of gallbladder. Many inflammatory markers are frequently used in the diagnostic process. In this study, we wanted to show the diagnostic efficacy of the systemic inflammatory response index (SIRI) and systemic immune inflammation index (SII) in patients with AC. Methods: This retrospective study was conducted in subjects diagnosed with AC between January 1, 2020, and June 1, 2022. The control group was randomly selected from subjects who attended to the emergency department with abdominal pain and did not need hospitalization, among subjects of similar age and gender to our study group. Demographic data and laboratory parameters of the patients were collected. Results: One hundred and thirty-three AC patients who met the inclusion criteria were included. Eighty-five patients with similar demographic data were included as a control group. The mean median SIRI levels of the patients were significantly higher than the control group (2.88 vs. 1.35; P < 0.001). In addition, the median SII levels of the patients were found to be significantly higher than the control group (1019.42 vs. 573.80; P < 0.001). Conclusions: We found that SIRI and SII are markers that can be used diagnostically in patients with AC and can be used as an option to C-reactive protein.