Chronic lymphocytic lymphoma (CLL) is a lymphoproliferative malignancy characterized by the generation and accumulation of CD5+ monoclonal B-cell lymphocytes, which are physically mature lymphocytes with aberrant immunological activity. The common presenting features are lymphadenopathy and leukocytosis. Because of its asymptomatic and indolent appearance, CLL requires a high index of suspicion to be diagnosed. Our patient presented with unusual symptoms of malignant polyserositis without substantial lymphadenopathy or hepatosplenomegaly. Ascitic fluid cytology and flow cytometry were done to confirm the diagnosis. The patient was staged modified Rai 0 and Binet A and categorized as low-risk status. Treatment is usually advised at Rai stage II and Binet stage B and higher. Although there is no mention of ascites or pleural effusion in the staging disease or deciding therapy, malignant polyserositis carries a poor prognosis and the decision to treat should be individualized. Our patient was offered chemotherapy but the patient denied it. He was on regular follow-ups receiving palliative therapy.
慢性淋巴细胞淋巴瘤（CLL）是一种淋巴组织增生性恶性肿瘤，其特征是 CD5+ 单克隆 B 细胞淋巴细胞的生成和聚集，这些淋巴细胞是具有异常免疫活性的物理成熟淋巴细胞。常见的表现特征是淋巴结肿大和白细胞增多。由于 CLL 无症状且症状不明显，因此需要高度怀疑才能确诊。我们的患者出现了恶性多发性骨髓炎的异常症状，但没有实质性淋巴结病变或肝脾肿大。为了确诊，我们对患者进行了腹腔积液细胞学检查和流式细胞术检查。对患者进行了改良的 Rai 0 期和 Binet A 期分期，并将其归类为低风险状态。通常建议在 Rai II 期和 Binet B 期及以上进行治疗。虽然在疾病分期或决定治疗时没有提及腹水或胸腔积液，但恶性多发性浆细胞炎的预后较差，因此应根据个体情况决定是否治疗。医生为我们的患者提供了化疗，但患者拒绝了。他定期接受随访，接受姑息治疗。
{"title":"Polyserositis as an Initial Manifestation of Chronic Lymphocytic Lymphoma","authors":"Sunita Aggarwal, Anshul Tomar, Ranvijay Singh, Pradeep Kumar, Sudipta Nandi, Meeta Singh, Kamal Garg, Dhananjay Muralidhar Kharche","doi":"10.4103/injms.injms_150_23","DOIUrl":"https://doi.org/10.4103/injms.injms_150_23","url":null,"abstract":"\u0000 Chronic lymphocytic lymphoma (CLL) is a lymphoproliferative malignancy characterized by the generation and accumulation of CD5+ monoclonal B-cell lymphocytes, which are physically mature lymphocytes with aberrant immunological activity. The common presenting features are lymphadenopathy and leukocytosis. Because of its asymptomatic and indolent appearance, CLL requires a high index of suspicion to be diagnosed. Our patient presented with unusual symptoms of malignant polyserositis without substantial lymphadenopathy or hepatosplenomegaly. Ascitic fluid cytology and flow cytometry were done to confirm the diagnosis. The patient was staged modified Rai 0 and Binet A and categorized as low-risk status. Treatment is usually advised at Rai stage II and Binet stage B and higher. Although there is no mention of ascites or pleural effusion in the staging disease or deciding therapy, malignant polyserositis carries a poor prognosis and the decision to treat should be individualized. Our patient was offered chemotherapy but the patient denied it. He was on regular follow-ups receiving palliative therapy.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_2_23
O. Olorunfemi, I. Awe, G. Ogbeye, O. Oluwagbemi, W. Tijani
Background: Many human rights issues addressed by various right conventions center on breastfeeding. One of these is the Convention on the Rights of the Child, which outlines fundamental human rights for children, such as the right to life, the right to develop to their full potential, and the right to be protected from harmful influences. Aims: The aim of this study was to evaluate the elements affecting working-class women's exclusive breastfeeding. Materials and Methods: The sample size (n = 196) for a descriptive cross-sectional study that ran from September 2022 to December 2022 was determined using a multistage sampling procedure. Tables, percentages, and Chi-square test statistics were employed at the 0.05 level of significance to examine the data using the Statistical Package Service Software (SPSS) version 23.0. Results: 48% of the respondents were within the age of 30 and 39 years. The majority of respondents (98%) identified the following factors as influencing the practice of exclusive breastfeeding among working-class women: job (93.9%), sore nipple (86.2%), insufficient lactation (43.9%), nipple not prominent (15.8%), not allowed by work (93.9%), breast milk alone before 6 months does not satisfy my baby (58.7%), lack of support from husband (67.9%), mother-in-law (76.5%), as well as inadequate maternity leave (67.9%) as the factors influencing the practice of exclusive breastfeeding among working-class women. In addition, this study shows a significant correlation between working-class women's Knowledge of exclusive breastfeeding and age (Chi-square = 6.016, df = 3, P = 0.024) and the number of children they had (Chi-square = 5.816, df = 3, P = 0.011). Conclusions: This study therefore suggests, among other things, that the state and federal Ministries of Labor and Employment set up childcare for the infant close to the mothers' places of employment to allow their babies to be brought to the workplace or breastfeeding mothers to go to the childcare facility at the time of breastfeeding.
{"title":"Factors working against exclusive breastfeeding among working-class women living around Dagiri Gwagwalada Area Council, Abuja","authors":"O. Olorunfemi, I. Awe, G. Ogbeye, O. Oluwagbemi, W. Tijani","doi":"10.4103/injms.injms_2_23","DOIUrl":"https://doi.org/10.4103/injms.injms_2_23","url":null,"abstract":"Background: Many human rights issues addressed by various right conventions center on breastfeeding. One of these is the Convention on the Rights of the Child, which outlines fundamental human rights for children, such as the right to life, the right to develop to their full potential, and the right to be protected from harmful influences. Aims: The aim of this study was to evaluate the elements affecting working-class women's exclusive breastfeeding. Materials and Methods: The sample size (n = 196) for a descriptive cross-sectional study that ran from September 2022 to December 2022 was determined using a multistage sampling procedure. Tables, percentages, and Chi-square test statistics were employed at the 0.05 level of significance to examine the data using the Statistical Package Service Software (SPSS) version 23.0. Results: 48% of the respondents were within the age of 30 and 39 years. The majority of respondents (98%) identified the following factors as influencing the practice of exclusive breastfeeding among working-class women: job (93.9%), sore nipple (86.2%), insufficient lactation (43.9%), nipple not prominent (15.8%), not allowed by work (93.9%), breast milk alone before 6 months does not satisfy my baby (58.7%), lack of support from husband (67.9%), mother-in-law (76.5%), as well as inadequate maternity leave (67.9%) as the factors influencing the practice of exclusive breastfeeding among working-class women. In addition, this study shows a significant correlation between working-class women's Knowledge of exclusive breastfeeding and age (Chi-square = 6.016, df = 3, P = 0.024) and the number of children they had (Chi-square = 5.816, df = 3, P = 0.011). Conclusions: This study therefore suggests, among other things, that the state and federal Ministries of Labor and Employment set up childcare for the infant close to the mothers' places of employment to allow their babies to be brought to the workplace or breastfeeding mothers to go to the childcare facility at the time of breastfeeding.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46697804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_142_22
J. Kausik, D. Divya, S. Parthasarathy
A 29-year-old primigravida parturient at term with a known case of hypothyroidism for the past 1 year was taken for emergency cesarean section in view of fetal distress. The patient's medical history showed a history of galactorrhea, for which magnetic resonance imaging of the brain and the routine blood investigations were normal. The parturient was posted for emergency cesarean section due to fetal distress. There was no significant comorbid illness or illicit drug intake. All the basic investigations including the thyroid-stimulating hormone were normal. Spinal anesthesia with 2.0 ml of 0.5% hyperbaric bupivacaine to achieve a level of T6 was performed. After the delivery of the fetus, there was a sudden seizure occurred, and the mother lost her consciousness. The hemodynamics remained stable. The patient was given oxygen, 2 mg of intravenous midazolam, and magnesium sulfate by the Pritchard regimen. The newborn's Apgar scores were normal. She had no recollection of the seizure attack after regaining consciousness and normal spontaneous respiration which occurred in a few minutes. Breastfeeding was recommended. To avoid another seizure episode, the Pritchard regimen was followed. The recovery period was uneventful. A cranial computed tomography scan of the brain was also performed, which revealed no abnormalities. Serum electrolytes were within the normal range when tested again. This case is being reported to raise awareness of seizures in nonhypertensive patients.
{"title":"Sudden and unexpected seizure during emergency cesarean section in a nonhypertensive hypothyroid primigravida","authors":"J. Kausik, D. Divya, S. Parthasarathy","doi":"10.4103/injms.injms_142_22","DOIUrl":"https://doi.org/10.4103/injms.injms_142_22","url":null,"abstract":"A 29-year-old primigravida parturient at term with a known case of hypothyroidism for the past 1 year was taken for emergency cesarean section in view of fetal distress. The patient's medical history showed a history of galactorrhea, for which magnetic resonance imaging of the brain and the routine blood investigations were normal. The parturient was posted for emergency cesarean section due to fetal distress. There was no significant comorbid illness or illicit drug intake. All the basic investigations including the thyroid-stimulating hormone were normal. Spinal anesthesia with 2.0 ml of 0.5% hyperbaric bupivacaine to achieve a level of T6 was performed. After the delivery of the fetus, there was a sudden seizure occurred, and the mother lost her consciousness. The hemodynamics remained stable. The patient was given oxygen, 2 mg of intravenous midazolam, and magnesium sulfate by the Pritchard regimen. The newborn's Apgar scores were normal. She had no recollection of the seizure attack after regaining consciousness and normal spontaneous respiration which occurred in a few minutes. Breastfeeding was recommended. To avoid another seizure episode, the Pritchard regimen was followed. The recovery period was uneventful. A cranial computed tomography scan of the brain was also performed, which revealed no abnormalities. Serum electrolytes were within the normal range when tested again. This case is being reported to raise awareness of seizures in nonhypertensive patients.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42793370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_136_22
Soumya Bhowmik, K. Anand
There have been well-known headache precipitants already documented in the literature. Laughter has previously been found as a rare trigger of headache in some individuals. Laughter-induced headache is a rare type of triggered headache which can share some similarities with primary cough headache or primary exercise headache. We report a case of abrupt onset, bilateral temporo-occipital headache, typically triggered exclusively by loud laughter in a 30-year-old male, with normal neurological examination and neuroimaging brain. The patient has shown some excellent responses to treatment with sodium valproate.
{"title":"Laughter-induced headache? Yes, it is possible!","authors":"Soumya Bhowmik, K. Anand","doi":"10.4103/injms.injms_136_22","DOIUrl":"https://doi.org/10.4103/injms.injms_136_22","url":null,"abstract":"There have been well-known headache precipitants already documented in the literature. Laughter has previously been found as a rare trigger of headache in some individuals. Laughter-induced headache is a rare type of triggered headache which can share some similarities with primary cough headache or primary exercise headache. We report a case of abrupt onset, bilateral temporo-occipital headache, typically triggered exclusively by loud laughter in a 30-year-old male, with normal neurological examination and neuroimaging brain. The patient has shown some excellent responses to treatment with sodium valproate.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49356854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_11_23
Tahereh Navadifar, Saba Karam, A. Emamie, Atieh Darbandi
A 30-year-old female who underwent an emergency cesarean section reported that the breast pump tubing, infant's pacifier, and soiled diapers turned pinkish after 24 h. Serratia marcescens was isolated from the mother's breast milk, breast pump tubing, and infant's stool. This mother had no mastitis or fever symptoms but received antibiotic therapy due to endometriosis and urinary tract infection. The infant had abdominal cramps, heartburn, and frequent bowel movements; however, he was afebrile and received no antibiotics. After 3 months, this infant returned to breastfeeding as his diaper's pinkish color disappeared and the culture of the mother's breast milk was negative.
{"title":"Identification of Serratia marcescens in a mother's expressed breast milk","authors":"Tahereh Navadifar, Saba Karam, A. Emamie, Atieh Darbandi","doi":"10.4103/injms.injms_11_23","DOIUrl":"https://doi.org/10.4103/injms.injms_11_23","url":null,"abstract":"A 30-year-old female who underwent an emergency cesarean section reported that the breast pump tubing, infant's pacifier, and soiled diapers turned pinkish after 24 h. Serratia marcescens was isolated from the mother's breast milk, breast pump tubing, and infant's stool. This mother had no mastitis or fever symptoms but received antibiotic therapy due to endometriosis and urinary tract infection. The infant had abdominal cramps, heartburn, and frequent bowel movements; however, he was afebrile and received no antibiotics. After 3 months, this infant returned to breastfeeding as his diaper's pinkish color disappeared and the culture of the mother's breast milk was negative.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48158922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_8_23
Anwita Khaitan, S. Rai, A. Krishnan, S. Gupta, S. Kant, G. Khilnani
Introduction: Treatment loss-to-follow-up (LTFU) is a great obstacle to tuberculosis (TB) elimination. Our objective was to estimate its prevalence in district Faridabad, Haryana, and to see its association with selected variables. Materials and Methods: We conducted a desk review of TB notification registers of two TB units under a district TB center, Faridabad. All patients registered between October 1, 2016, and September 30, 2017, were analyzed. Following univariate analysis, factors with P < 0.2 were included in the multivariable logistic regression model. Results: Of 999 eligible patients, 742 (74.2%) had treatment outcomes available. LTFU was estimated to be 3.5%, with cumulative incidence calculated to be 6.63 LTFUs per 100 person-years. LTFU increased with increasing age. LTFU was 5.2% (9.8 LTFUs per 100 person-years) and 0.3% (0.6 LTFUs per 100 person-years) among pulmonary TB (PTB) and extra-PTB (EPTB) patients, respectively. LTFU was higher in patients with previous relapse (9% or 14.2 LTFU per 100 person-years) and previous LTFU (16% or 32 LTFUs per 100 person-years) as compared to only 2.4% (4.7 per 100 person-years) among new patients. PTB patients and patients on treatment after prior LTFU had 12 times and 5 times higher odds of LTFU than EPTB patients and new patients, respectively. Conclusion: The observed LTFU burden is lower than the <5% target set by the National TB Elimination Program. Lack of information on outcomes under the program should be cause for concern. Special attention should be paid under the program on high-risk groups identified to ensure treatment adherence.
{"title":"Loss-to-follow-up rate among tuberculosis patients registered at two tuberculosis units of ballabgarh block of district Faridabad, Haryana: A desk review","authors":"Anwita Khaitan, S. Rai, A. Krishnan, S. Gupta, S. Kant, G. Khilnani","doi":"10.4103/injms.injms_8_23","DOIUrl":"https://doi.org/10.4103/injms.injms_8_23","url":null,"abstract":"Introduction: Treatment loss-to-follow-up (LTFU) is a great obstacle to tuberculosis (TB) elimination. Our objective was to estimate its prevalence in district Faridabad, Haryana, and to see its association with selected variables. Materials and Methods: We conducted a desk review of TB notification registers of two TB units under a district TB center, Faridabad. All patients registered between October 1, 2016, and September 30, 2017, were analyzed. Following univariate analysis, factors with P < 0.2 were included in the multivariable logistic regression model. Results: Of 999 eligible patients, 742 (74.2%) had treatment outcomes available. LTFU was estimated to be 3.5%, with cumulative incidence calculated to be 6.63 LTFUs per 100 person-years. LTFU increased with increasing age. LTFU was 5.2% (9.8 LTFUs per 100 person-years) and 0.3% (0.6 LTFUs per 100 person-years) among pulmonary TB (PTB) and extra-PTB (EPTB) patients, respectively. LTFU was higher in patients with previous relapse (9% or 14.2 LTFU per 100 person-years) and previous LTFU (16% or 32 LTFUs per 100 person-years) as compared to only 2.4% (4.7 per 100 person-years) among new patients. PTB patients and patients on treatment after prior LTFU had 12 times and 5 times higher odds of LTFU than EPTB patients and new patients, respectively. Conclusion: The observed LTFU burden is lower than the <5% target set by the National TB Elimination Program. Lack of information on outcomes under the program should be cause for concern. Special attention should be paid under the program on high-risk groups identified to ensure treatment adherence.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41805199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_7_23
H. Patel, Balaganapathy Muruganantham
Background: Knee osteoarthritis is one of the leading causes of the increasing global burden of musculoskeletal disorders. The prevalence rate of patellofemoral arthritis is 39% in South Asia in >40 years of age. The census on early osteoarthritis recommends focusing on the prediagnostic stage. However, none of the tools is available to screen the early symptoms of patellofemoral arthritis. Purpose of the Study: The purpose of this study was to develop and evaluate the psychometric properties of the CHARUSAT Patellofemoral Arthritis Questionnaire. Methods: The questionnaire was developed using a mixed method stepwise approach. The participant with early patellofemoral arthritis (n = 14) was interviewed. We conducted scoping review and in-depth interviews to develop a conceptual framework. Initial content validation was completed through community consultation and expert opinion. Final psychometric validation was conducted on n = 310 individuals with early patellofemoral arthritis. Participants were recruited from tertiary hospitals' outpatient units and regional communities in India. Results: Conceptual framework was developed based on the current literature review, and qualitative data obtained from participants finalized the 4 domains and 12 content versions: crepitus (2 items), stiffness (2 items), pain (2 items), and difficulty in functional activity (6 items). The psychometric measurement demonstrated good internal consistency, Cronbach's alpha α was 0.90 and an acceptable level of inter-item redundancy. The intraclass correlation coefficient (ICC) value for the test and retest assessment was 0.93 (ICC:2,1; 95% confidence interval = 0.880–0.936; P < 0.000). Principal component analysis demonstrates a four-factor solution with 56.83% total variance. Conclusions: It is an acceptable, reliable, and valid self-administered questionnaire that can identify the early symptoms of patellofemoral arthritis. The questionnaire provides an excellent opportunity for self-analysis of the symptoms at the community level.
{"title":"Development and preliminary evaluation of the CHARUSAT patellofemoral arthritis questionnaire: A psychometric study","authors":"H. Patel, Balaganapathy Muruganantham","doi":"10.4103/injms.injms_7_23","DOIUrl":"https://doi.org/10.4103/injms.injms_7_23","url":null,"abstract":"Background: Knee osteoarthritis is one of the leading causes of the increasing global burden of musculoskeletal disorders. The prevalence rate of patellofemoral arthritis is 39% in South Asia in >40 years of age. The census on early osteoarthritis recommends focusing on the prediagnostic stage. However, none of the tools is available to screen the early symptoms of patellofemoral arthritis. Purpose of the Study: The purpose of this study was to develop and evaluate the psychometric properties of the CHARUSAT Patellofemoral Arthritis Questionnaire. Methods: The questionnaire was developed using a mixed method stepwise approach. The participant with early patellofemoral arthritis (n = 14) was interviewed. We conducted scoping review and in-depth interviews to develop a conceptual framework. Initial content validation was completed through community consultation and expert opinion. Final psychometric validation was conducted on n = 310 individuals with early patellofemoral arthritis. Participants were recruited from tertiary hospitals' outpatient units and regional communities in India. Results: Conceptual framework was developed based on the current literature review, and qualitative data obtained from participants finalized the 4 domains and 12 content versions: crepitus (2 items), stiffness (2 items), pain (2 items), and difficulty in functional activity (6 items). The psychometric measurement demonstrated good internal consistency, Cronbach's alpha α was 0.90 and an acceptable level of inter-item redundancy. The intraclass correlation coefficient (ICC) value for the test and retest assessment was 0.93 (ICC:2,1; 95% confidence interval = 0.880–0.936; P < 0.000). Principal component analysis demonstrates a four-factor solution with 56.83% total variance. Conclusions: It is an acceptable, reliable, and valid self-administered questionnaire that can identify the early symptoms of patellofemoral arthritis. The questionnaire provides an excellent opportunity for self-analysis of the symptoms at the community level.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70773337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_5_23
G. Yıldız, F. Selvi, C. Bedel, Ökkeş Zortuk, M. Korkut, U. Mutlucan
Objective: Acute cholecystitis (AC) is a condition caused by acute inflammation of gallbladder. Many inflammatory markers are frequently used in the diagnostic process. In this study, we wanted to show the diagnostic efficacy of the systemic inflammatory response index (SIRI) and systemic immune inflammation index (SII) in patients with AC. Methods: This retrospective study was conducted in subjects diagnosed with AC between January 1, 2020, and June 1, 2022. The control group was randomly selected from subjects who attended to the emergency department with abdominal pain and did not need hospitalization, among subjects of similar age and gender to our study group. Demographic data and laboratory parameters of the patients were collected. Results: One hundred and thirty-three AC patients who met the inclusion criteria were included. Eighty-five patients with similar demographic data were included as a control group. The mean median SIRI levels of the patients were significantly higher than the control group (2.88 vs. 1.35; P < 0.001). In addition, the median SII levels of the patients were found to be significantly higher than the control group (1019.42 vs. 573.80; P < 0.001). Conclusions: We found that SIRI and SII are markers that can be used diagnostically in patients with AC and can be used as an option to C-reactive protein.
目的:急性胆囊炎是一种由胆囊急性炎症引起的疾病。在诊断过程中经常使用许多炎症标志物。在本研究中，我们希望展示全身炎症反应指数(SIRI)和全身免疫炎症指数(SII)对AC患者的诊断效果。方法:本回顾性研究在2020年1月1日至2022年6月1日期间诊断为AC的受试者中进行。对照组随机选择在与本研究组年龄、性别相近的就诊于急诊科且不需要住院治疗的腹痛患者。收集患者的人口学资料和实验室参数。结果:133例AC患者符合纳入标准。85例人口统计学资料相似的患者作为对照组。患者的SIRI平均中位水平显著高于对照组(2.88 vs 1.35;P < 0.001)。此外，发现患者的SII中位数水平显著高于对照组(1019.42 vs 573.80;P < 0.001)。结论:我们发现SIRI和SII是可用于AC患者诊断的标记物，可作为c反应蛋白的一种选择。
{"title":"Systemic inflammation response index and systemic immune inflammation index for predicting acute cholecystitis","authors":"G. Yıldız, F. Selvi, C. Bedel, Ökkeş Zortuk, M. Korkut, U. Mutlucan","doi":"10.4103/injms.injms_5_23","DOIUrl":"https://doi.org/10.4103/injms.injms_5_23","url":null,"abstract":"Objective: Acute cholecystitis (AC) is a condition caused by acute inflammation of gallbladder. Many inflammatory markers are frequently used in the diagnostic process. In this study, we wanted to show the diagnostic efficacy of the systemic inflammatory response index (SIRI) and systemic immune inflammation index (SII) in patients with AC. Methods: This retrospective study was conducted in subjects diagnosed with AC between January 1, 2020, and June 1, 2022. The control group was randomly selected from subjects who attended to the emergency department with abdominal pain and did not need hospitalization, among subjects of similar age and gender to our study group. Demographic data and laboratory parameters of the patients were collected. Results: One hundred and thirty-three AC patients who met the inclusion criteria were included. Eighty-five patients with similar demographic data were included as a control group. The mean median SIRI levels of the patients were significantly higher than the control group (2.88 vs. 1.35; P < 0.001). In addition, the median SII levels of the patients were found to be significantly higher than the control group (1019.42 vs. 573.80; P < 0.001). Conclusions: We found that SIRI and SII are markers that can be used diagnostically in patients with AC and can be used as an option to C-reactive protein.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43617663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_9_23
Suraj Hiwarkar, M. Holay, Bhiwagade Rahul, Patil Prashant
Background: Zinc increases the natural defense of reactive oxygen radicals; Zinc also acts as an antioxidant, an anti-apoptotic agent, a cofactor for DNA synthesis, and an anti-inflammatory agent. Hence, deficient zinc levels seem to have an effect in the pathogenesis of hepatic encephalopathy (HE). Aims: This prospective observational study was done to assess serum zinc levels in cases of liver cirrhosis with decompensated liver disease (DCLD) and to see the correlation of serum zinc levels with stages of HE and patients' outcome. Materials and Methods: This prospective observational study was conducted at a tertiary care institution in Central India. Total 66 cases of liver cirrhosis with DCLD were studied. Fifty healthy controls were enrolled. All cases were evaluated for serum zinc levels, and all were divided further according to the class of liver cirrhosis and stages of HE. The association between serum zinc level and stages of HE and outcome was studied. The data were analyzed with SPSS software version 22. Results: The mean age of the cases at presentation was 45.67 ± 8.73 years. The M: F ratio was 10:1. The mean serum zinc level in controls was 104.16 ± 22.60 μg/dl, while in cases, it was 47.68 ± 16.72 μg/dl. It was significantly low in cases as compared to the controls, P < 0.0001. An inverse correlation was observed between serum zinc and West Haven classification grading of HE. There was found a direct correlation between serum zinc level and serum albumin. The lesser the serum albumin, the lesser the serum zinc level. P <0.0001 was highly significant. The mean serum zinc level was 57.67 μg/dl in survivors 40 cases (60.61%) as compared to 32.30 μg/dl in nonsurvivors 26 (39.30%). Low serum zinc level was associated with high mortality. P <0.0001 was statistically highly significant. Conclusion: Low serum zinc is associated with cirrhosis of the liver, DCLD, and high incidence of HE. Hence, all patients of cirrhosis liver with hypoalbuminemia and HE should be evaluated for low serum zinc. Low serum zinc in HE was associated with high mortality. The present study could not establish a causal relationship between low serum zinc and liver cirrhosis with DCLD having HE. Whether correction of zinc in these cases can prevent worsening, HE needs further evaluation.
{"title":"Study of serum zinc level in liver cirrhosis and its correlation with stages of hepatic encephalopathy","authors":"Suraj Hiwarkar, M. Holay, Bhiwagade Rahul, Patil Prashant","doi":"10.4103/injms.injms_9_23","DOIUrl":"https://doi.org/10.4103/injms.injms_9_23","url":null,"abstract":"Background: Zinc increases the natural defense of reactive oxygen radicals; Zinc also acts as an antioxidant, an anti-apoptotic agent, a cofactor for DNA synthesis, and an anti-inflammatory agent. Hence, deficient zinc levels seem to have an effect in the pathogenesis of hepatic encephalopathy (HE). Aims: This prospective observational study was done to assess serum zinc levels in cases of liver cirrhosis with decompensated liver disease (DCLD) and to see the correlation of serum zinc levels with stages of HE and patients' outcome. Materials and Methods: This prospective observational study was conducted at a tertiary care institution in Central India. Total 66 cases of liver cirrhosis with DCLD were studied. Fifty healthy controls were enrolled. All cases were evaluated for serum zinc levels, and all were divided further according to the class of liver cirrhosis and stages of HE. The association between serum zinc level and stages of HE and outcome was studied. The data were analyzed with SPSS software version 22. Results: The mean age of the cases at presentation was 45.67 ± 8.73 years. The M: F ratio was 10:1. The mean serum zinc level in controls was 104.16 ± 22.60 μg/dl, while in cases, it was 47.68 ± 16.72 μg/dl. It was significantly low in cases as compared to the controls, P < 0.0001. An inverse correlation was observed between serum zinc and West Haven classification grading of HE. There was found a direct correlation between serum zinc level and serum albumin. The lesser the serum albumin, the lesser the serum zinc level. P <0.0001 was highly significant. The mean serum zinc level was 57.67 μg/dl in survivors 40 cases (60.61%) as compared to 32.30 μg/dl in nonsurvivors 26 (39.30%). Low serum zinc level was associated with high mortality. P <0.0001 was statistically highly significant. Conclusion: Low serum zinc is associated with cirrhosis of the liver, DCLD, and high incidence of HE. Hence, all patients of cirrhosis liver with hypoalbuminemia and HE should be evaluated for low serum zinc. Low serum zinc in HE was associated with high mortality. The present study could not establish a causal relationship between low serum zinc and liver cirrhosis with DCLD having HE. Whether correction of zinc in these cases can prevent worsening, HE needs further evaluation.","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43866537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.4103/injms.injms_47_23
N. Sethi, Ashwani Kumar, N. Prakash
{"title":"Cardiovascular effects of adult vaccines","authors":"N. Sethi, Ashwani Kumar, N. Prakash","doi":"10.4103/injms.injms_47_23","DOIUrl":"https://doi.org/10.4103/injms.injms_47_23","url":null,"abstract":"","PeriodicalId":43811,"journal":{"name":"Indian Journal of Medical Specialities","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47393226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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