与早发性、青少年和青年结直肠癌相关的基因组和分子改变

IF 2.7 Q3 ONCOLOGY Colorectal Cancer Pub Date : 2020-09-01 DOI:10.2217/crc-2020-0009

J. V. Tricoli

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引用次数: 1

摘要

虽然美国癌症（CRC）的发病率在2003年至2012年间以每年3%的速度下降，但早发性癌症（EOCRC）的发生率却有所上升。这一增长的原因尚不清楚。饮食、环境、微生物组和饮酒都被认为是促成因素。EOCRC有可能具有独特的生物学特性。与EOCRC年龄范围重叠的是青少年和年轻人的CRC（AYA），其与EOCRC有许多共同的分子特征。这篇综述的目的是在青少年和年轻人CRC和EOCRC的背景下，介绍我们对CRC生物学理解的当前进展，并讨论未来的方向。

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Genomic and molecular alterations associated with early-onset and adolescent and young adult colorectal cancer

While the incidence of colorectal cancer (CRC) in the US has declined at a pace of 3% annually between 2003 and 2012, there has been an increase in the incidence of early-onset colorectal cancer (EOCRC). The reasons for this increase are unclear. Diet, the environment, the microbiome and alcohol consumption have all been proposed as contributing factors. There is the possibility that EOCRC has a unique biology. Overlapping with the EOCRC age range is CRC in adolescent and young adults (AYA) that share many molecular characteristics with EOCRC. The purpose of this review is to cover current progress in our understanding of the biology of CRC in the context of adolescent and young adult CRC and EOCRC and discuss future directions.

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.