新冠病毒后糖尿病出版社?

IF 0.1 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Investigacion clinica Pub Date : 2022-03-23 DOI:10.54817/ic.v63n1a00
Nereida Josefina Valero Cedeño
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引用次数: 0

摘要

如果后续研究证实,2019冠状病毒病患者出现糖尿病(DM)可能会被添加到本次大流行造成的一长串后果中。同样,COVID-19对内分泌系统的影响研究也很少。以前的冠状病毒爆发以及其他先前报道的病毒感染与新发糖尿病有关。然而,这方面的研究很少,问题再次出现,即病毒如何导致疾病的发作,或者它们是否会改变最终引发血糖控制缺失的因素,以及胰岛素抵抗(IR)。最近的COVID-19大流行充分表明,糖尿病增加了更频繁和更严重的病毒感染的风险。同时,促炎细胞因子促进IR并构成糖尿病发展的危险因素。这表明在糖尿病的背景下,免疫系统和内分泌系统之间存在互惠和有害的相互作用。目前尚不清楚为什么这两个系统会通过诱导全身代谢的短暂变化来相互作用,作为对抗病毒感染的策略。在糖尿病患者中,该系统失效,对抗病毒免疫反应产生负面影响。此外,感染后免疫介导的全身代谢变化可能使血糖控制恶化,为今后的研究奠定基础。
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EDITORIAL ¿Diabetes post COVID-19?
The appearance of Diabetes Mellitus (DM) in patients who have suffered from COVID-19 could be added, if confirmed by subsequent studies, to the long list of consequences caused by this pandemic. Likewise, the impact of COVID-19 on the endocrine system is poorly studied. Previous coronavirus outbreaks, as well as other previously reported viral infections, have been associated with new-onset DM. However, there is little research in this regard and the question arises again as to how viruses can contribute to the onset of the disease or if they modify factors that ultimately trigger the lack of control of blood glucose, together with insulin resistance (IR). The recent COVID-19 pandemic has made it abundantly clear that DM increases the risk of more frequent and severe viral infections. At the same time, proinflammatory cytokines promote IR and constitute a risk factor for the development of DM. This raises the existence of a reciprocal and harmful interaction between the immune and endocrine systems in the context of DM. It is not clear why these two systems would interact by inducing transient changes in systemic metabolism as a strategy against viral infection. In people with DM, this system fails, negatively affecting the antiviral immune response. In addition, immune-mediated changes in systemic metabolism after infection may worsen glycemic control, laying the groundwork for future research.
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来源期刊
Investigacion clinica
Investigacion clinica MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
0.20
自引率
50.00%
发文量
2
审稿时长
>12 weeks
期刊介绍: Estudios humanos, animales y de laboratorio relacionados con la investigación clínica y asuntos conexos.
期刊最新文献
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