重新发明的磁共振肠造影:探索一种新的天然饮料作为聚乙二醇溶液替代品的潜力

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY Gastroenterology Insights Pub Date : 2023-08-04 DOI:10.3390/gastroent14030023
M. Renzulli, M. A. Cocozza, M. Biselli, A. Cattabriga, N. Brandi, F. Giannone, Marco Storchi, P. Gionchetti, G. Poggioli, S. Laureti, R. Golfieri, A. Cappelli
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引用次数: 0

摘要

本研究的目的是测试一种由天然成分组成的新型口服造影剂,用于小肠疾病的磁共振(MR)成像。在2018年1月至2019年6月期间,35名受回结肠性克罗恩病(CD)影响的患者参加了本研究。每位患者进行两次连续MR肠造影,第一次用标准聚乙二醇(PEG)水溶液,3周后用我们团队设计的新型天然饮料。在每次口服对照的管理结束时,对患者进行满意度调查,以评估两种饮料的适口性。两项研究的两名放射科专家评估了肠道膨胀和图像质量,并计算了解读者的一致性。满意度问卷显示,97.1%的患者对天然饮料(71.4%非常好,25.7%良好)表示肯定,而对PEG水溶液(8.6%良好)表示赞赏的患者仅占8.6% (p = 0.0001)。97.1%的患者在服用PEG后肠胀程度为优,94.3%的患者在服用天然饮料后肠胀程度为良,两种产品之间无显著差异,观察者间变异性分别接近完美(k = 0.821)和显著(k = 0.754)。两名放射科专家对成像质量的评价无统计学差异;特别是,100%服用PEG水溶液的患者和97.2%服用天然饮料的患者认为它们是良好和优秀的,分别具有大量(k = 0.618)和几乎完美(k = 0.858)的观察者间变异性。与合成标准口服造影剂相比,这种新型天然饮料在小肠疾病的MRE治疗中表现出相同的肠道膨胀和优异的图像质量,证明是一种有效的替代品,具有更好的适口性。
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Magnetic Resonance Enterography Reinvented: Exploring the Potential of a New Natural Beverage as an Alternative to Polyethylene Glycol Solution
The aim of the present study was to test a new oral contrast medium composed of natural components for the magnetic resonance (MR) imaging of small bowel diseases. Between January 2018 and June 2019, 35 patients affected by ileocolic Crohn’s disease (CD) were enrolled in the present study. Each patient underwent two sequential MR enterographies, first with the standard polyethylene glycol (PEG) water solution and, after 3 weeks, with the new natural beverage designed by our team. At the end of the administration of each oral contrast, a satisfaction survey was given to the patients to assess the palatability of both beverages. The intestinal distention and the quality of images were evaluated by two expert radiologists for both studies and the interreader agreement was calculated. According to the satisfaction questionnaire, 97.1% of patients expressed positive judgments regarding the natural beverage (71.4% very good and 25.7% good) whereas only 8.6% of them appreciated the PEG water solution (8.6% good) (p = 0.0001). The degree of intestinal distention was excellent and good in 97.1% of patients after the administration of PEG and in 94.3% of the patients after the administration of the natural beverage, without significant differences between the two products and with almost perfect (k = 0.821) and substantial (k = 0.754) inter-observer variability, respectively. No statistical differences were observed between the two expert radiologists regarding the evaluation of the imaging quality; in particular, they were considered good and excellent in 100% of patients after the administration of PEG water solution and in 97.2% of those who took the natural beverage, with substantial (k = 0.618) and almost perfect (k = 0.858) inter-observer variability, respectively. The new natural beverage demonstrated the same intestinal distension and excellent image quality compared to the synthetic standard oral contrast administered during MRE for small bowel diseases, proving to be a valid alternative with better palatability.
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来源期刊
Gastroenterology Insights
Gastroenterology Insights GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.80
自引率
3.40%
发文量
35
审稿时长
10 weeks
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