抗磷脂综合征孕妇血小板指数有变化吗?

IF 1.1 Q4 IMMUNOLOGY Immunopathologia Persa Pub Date : 2022-05-31 DOI:10.34172/ipp.2022.32410
Wassan Nori, Shaima K. Harmoosh, Roaa Hamed
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引用次数: 0

摘要

引言:复发性流产(RPL)是一种常见的产科并发症,50%的病因尚未确定。抗磷脂综合征(APL)是一种自身免疫性疾病,被认为是RPL的病因之一。血栓形成倾向,特别是血小板异常,被认定为RPL。目的:本研究的目的是确定血小板参数的变化;特别是抗磷脂综合征引起的RPL患者的血小板计数、平均血小板体积(MPV)、血小板分布宽度PDW。患者和方法:50名确诊为APL综合征并有RPL病史的女性被分配为研究组,50名在没有RPL的情况下分娩的女性被设定为健康对照,她们来自巴格达的al-Yarmouk教学医院。通过直接采访患者获取个人数据,采集血样并分析全血细胞计数和血小板指数。结果:血小板计数和PDW均与流产次数显著相关;两个变量的Pearson相关系数分别为(0.74,0.59)。ROC评估的血小板计数的敏感性和特异性分别为230、88%、84%,AUC=0.89,P值<0.001。PDW的临界值为13.6 fl/L,灵敏度和特异性分别为88%和80%,AUC=0.87,P值<0.001。结论:血小板指标可能有助于妇科医生在低资源环境下预测被认为患有RPL的高危妊娠。
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Is There a Change in Platelet Indices Among Pregnant With Anti Phospholipid Syndrome?
Introduction: Recurrent pregnancy loss (RPL) is a common obstetrical complication, where 50% have undetermined etiology. Antiphospholipid syndrome (APL) is an autoimmune disease documented as a cause of RPL. Thrombophilia, particularly platelet abnormalities, were accredited for RPL. Objectives: The purpose of this study is to determine the change in platelets parameters; specifically, platelet count, mean platelet volume (MPV), platelet distribution width PDW, in patients suffering from RPL caused by the anti-phospholipid syndrome. Patients and Methods: Fifty women with a confirmed diagnosis of APL syndrome having a history of RPL were assigned as a study group and fifty women who gave birth without RPL were set as healthy controls were taken from al Yarmouk teaching hospitals in Baghdad. The personal data were taken by direct interview with patients, and blood samples were taken and analyzed for complete blood counts and platelets indices. Results: Both platelets count and PDW scored significant correlation with the number of pregnancy loss; Pearson's correlation coefficient was (0.74,0.59) respectively for both variables. The ROC evaluated platelets count a cutoff value of 230 ,88%,84% respective sensitivity and specificities, AUC =0.89,and P-value<0.001 respectively. As for PDW it had a cutoff value of 13.6 fl/L,88%,80% respective sensitivity and specificities, AUC=0.87,and P-value<0.001. Conclusions: Platelet indicators may aid gynecologists' in low-resource settings in predicting high-risk pregnancies deemed to suffer from RPL .
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CiteScore
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0.00%
发文量
65
审稿时长
3 weeks
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