{"title":"双孔结构域K+通道TREK-1在麻醉中的作用","authors":"Shuai Zhao, Yeling Ouyang, Zhiqiang Hu, Xiangdong Chen","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.023","DOIUrl":null,"url":null,"abstract":"TREK-1, a member of two-pore domain K+ channel (K2P) family, has various functions and participates in the regulation of resting membrane potentials. Recent studies indicate that TREK-1 is essential in anesthesia, pain, neuroprotection and depression. Based on domestic and foreign literature related to TREK-1, this review concisely outlines the structure, function, distribution and modulation of TREK-1, and thoroughly presents the advances in those fields above. Furthermore, the role of TREK-1 in general anesthesia, pain, neuroprotection and depression has been elaborated, so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs. \n \n \nKey words: \nTREK-1; Tow-pore domain K+ channel; Anesthesia; Pain perception; Neuroprotection; Depression","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"105-110"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The involvement of two-pore domain K+ channel TREK-1 in anesthesia\",\"authors\":\"Shuai Zhao, Yeling Ouyang, Zhiqiang Hu, Xiangdong Chen\",\"doi\":\"10.3760/CMA.J.ISSN.1673-4378.2020.01.023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"TREK-1, a member of two-pore domain K+ channel (K2P) family, has various functions and participates in the regulation of resting membrane potentials. Recent studies indicate that TREK-1 is essential in anesthesia, pain, neuroprotection and depression. Based on domestic and foreign literature related to TREK-1, this review concisely outlines the structure, function, distribution and modulation of TREK-1, and thoroughly presents the advances in those fields above. Furthermore, the role of TREK-1 in general anesthesia, pain, neuroprotection and depression has been elaborated, so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs. \\n \\n \\nKey words: \\nTREK-1; Tow-pore domain K+ channel; Anesthesia; Pain perception; Neuroprotection; Depression\",\"PeriodicalId\":13847,\"journal\":{\"name\":\"国际麻醉学与复苏杂志\",\"volume\":\"41 1\",\"pages\":\"105-110\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际麻醉学与复苏杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际麻醉学与复苏杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The involvement of two-pore domain K+ channel TREK-1 in anesthesia
TREK-1, a member of two-pore domain K+ channel (K2P) family, has various functions and participates in the regulation of resting membrane potentials. Recent studies indicate that TREK-1 is essential in anesthesia, pain, neuroprotection and depression. Based on domestic and foreign literature related to TREK-1, this review concisely outlines the structure, function, distribution and modulation of TREK-1, and thoroughly presents the advances in those fields above. Furthermore, the role of TREK-1 in general anesthesia, pain, neuroprotection and depression has been elaborated, so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs.
Key words:
TREK-1; Tow-pore domain K+ channel; Anesthesia; Pain perception; Neuroprotection; Depression
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