上皮细胞FTL表达作为结肠腺癌预后的重要预测因子

Ziyang Sun, Siqi Zhang, Lei Zhao, Shuhao Wang, Zhen-dong Lin, A. Jin
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引用次数: 0

摘要

铁死亡已被证明是一个非自我凋亡,铁离子催化,控制细胞死亡过程涉及细胞脂质氧化物。可能影响铁下垂的基因可能是候选的生物标志物。但有关铁中毒相关基因在结直肠腺癌(COAD)中的价值和预测价值尚不完全清楚。因此,我们使用GEO、GEPIA和HPA数据库分析了COAD和健康结肠组织中的表达状况。使用cBioPortal、HPA、PrognoScan、STRING、GeneMANIA和LinkedOmics数据库研究了铁衰相关基因的预测和遗传改变的作用。免疫组化染色检测COAD中FTL的上皮和间质表达。利用FerrDb和GEO数据库,我们发现XBP1、TSC22D3和YWHAE的转录水平与肿瘤晚期相关,FTL、DUSP1、TSC22D3和GDF15与COAD预后不良相关。免疫组化染色显示,COAD组织中FTL明显上调。Cox生存分析和KM生存分析表明,高上皮FTL水平与COAD的不良预后相关。
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Identification of Epithelial FTL Expression as an Important Predictor for Prognosis of Colon Adenocarcinoma
Ferroptosis has been shown to be a non-self apoptotic, iron ion-catalysed, controlled cell death process involving cellular lipid oxides. The gnes that may affect ferroptosis may be candidate biomarkers. But the value and predictive value of ferroptosis-related genes in colorectal adenocarcinoma (COAD) are not fully understood. Therefore, we analyzed the expression status in COAD and healthy colon tissue using GEO, GEPIA and HPA databases. The role of predictive and genetic alterations of ferroptosis-related genes were investigated using cBioPortal, HPA, PrognoScan, STRING, GeneMANIA and LinkedOmics databases. Then, immunohistochemistry staining was performed to detect the both epithelial and stromal expression of FTL in COAD. Using FerrDb and GEO databases, the transcript levels of XBP1, TSC22D3 and YWHAE were identified to correlate with advanced tumor stage, FTL, DUSP1, TSC22D3 and GDF15 were related to poor prognosis of COAD. As immunohistochemistry staining shown that FTL was significantly up-regulated in COAD tissues. Cox survival analysis and KM survival analysis indicated that high epithelial FTL levels is associated with a poor prognosis in COAD.
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