{"title":"穴位刺激治疗儿童咳嗽变异性哮喘的疗效和安全性:meta分析","authors":"Jin Yutong , Chen Shan , Xuan Lihua","doi":"10.1016/S0254-6272(18)30880-X","DOIUrl":null,"url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To evaluate the efficacy and safety of stimulating acupoints in subjects with childhood cough variant asthma (CVA).</p></div><div><h3>METHODS</h3><p>A Meta-analysis of randomized controlled trials (RCTs) about the comparison between acupoint sticking therapy and non-acupoint sticking therapy for childhood CVA was conducted. The trials’ quality and risk bias were assessed using the Cochrane Handbook tool. Odds ratio (<em>OR</em>) or risk ratio (RR) with 95% confidence intervals (<em>CIs</em>), mean differences (<em>MD</em>s) or standardized mean differences (<em>SMD</em>s) of a random-effects model were calculated. Heterogeneity was assessed by <em>P</em> value and <em>I</em><sup>2</sup> statistics.</p></div><div><h3>RESULTS</h3><p>Thirteen studies were included in our review, indicating that the total effective rate of stimulating-acupoint group is better than that of control group [RR 1.19, 95% <em>CI</em> (1.13-1.26), <em>P</em> < 0.000 01]. The recurrence rate in two years [<em>RR</em> 0.31, 95% <em>CI</em> (0.19-0.51), <em>P</em> < 0.000 01] and cough duration [<em>MD</em> = −2.42, 95% <em>CI</em> (–3.75, −1.09), <em>P</em> = 0.0004] of childhood CVA in stimulating-acupoint group were significantly lower than those in control group. Besides, stimulating acupoints can reduce the level of IgE [SMD = −0.75, 95% <em>CI</em> (–1.21, −0.30), <em>P</em> = 0.001] and EOS [SMD = −0.36, 95% <em>CI</em> (–0.92,0.21), <em>P</em> =0.22].</p></div><div><h3>CONCLUSION</h3><p>Our findings suggest that stimulating acupoints had positive effects on childhood CVA and was relatively safe treatment. However, more RCTs with more useful indicators are warrant to confirm the current findings.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 4","pages":"Pages 480-489"},"PeriodicalIF":2.0000,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30880-X","citationCount":"2","resultStr":"{\"title\":\"Effect and safety of stimulating acupoints in children with cough variant asthma: A Meta-analysis\",\"authors\":\"Jin Yutong , Chen Shan , Xuan Lihua\",\"doi\":\"10.1016/S0254-6272(18)30880-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>OBJECTIVE</h3><p>To evaluate the efficacy and safety of stimulating acupoints in subjects with childhood cough variant asthma (CVA).</p></div><div><h3>METHODS</h3><p>A Meta-analysis of randomized controlled trials (RCTs) about the comparison between acupoint sticking therapy and non-acupoint sticking therapy for childhood CVA was conducted. The trials’ quality and risk bias were assessed using the Cochrane Handbook tool. Odds ratio (<em>OR</em>) or risk ratio (RR) with 95% confidence intervals (<em>CIs</em>), mean differences (<em>MD</em>s) or standardized mean differences (<em>SMD</em>s) of a random-effects model were calculated. Heterogeneity was assessed by <em>P</em> value and <em>I</em><sup>2</sup> statistics.</p></div><div><h3>RESULTS</h3><p>Thirteen studies were included in our review, indicating that the total effective rate of stimulating-acupoint group is better than that of control group [RR 1.19, 95% <em>CI</em> (1.13-1.26), <em>P</em> < 0.000 01]. The recurrence rate in two years [<em>RR</em> 0.31, 95% <em>CI</em> (0.19-0.51), <em>P</em> < 0.000 01] and cough duration [<em>MD</em> = −2.42, 95% <em>CI</em> (–3.75, −1.09), <em>P</em> = 0.0004] of childhood CVA in stimulating-acupoint group were significantly lower than those in control group. Besides, stimulating acupoints can reduce the level of IgE [SMD = −0.75, 95% <em>CI</em> (–1.21, −0.30), <em>P</em> = 0.001] and EOS [SMD = −0.36, 95% <em>CI</em> (–0.92,0.21), <em>P</em> =0.22].</p></div><div><h3>CONCLUSION</h3><p>Our findings suggest that stimulating acupoints had positive effects on childhood CVA and was relatively safe treatment. 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引用次数: 2
摘要
目的评价穴位刺激法治疗儿童咳嗽变异性哮喘(CVA)的疗效和安全性。方法对穴位贴敷治疗与非穴位贴敷治疗儿童CVA的随机对照试验进行meta分析。使用Cochrane手册工具评估试验的质量和风险偏倚。计算随机效应模型的95%置信区间(ci)的优势比(OR)或风险比(RR)、平均差异(MDs)或标准化平均差异(SMDs)。采用P值和I2统计量评价异质性。结果纳入13项研究,穴位刺激组总有效率优于对照组[RR 1.19, 95% CI (1.13-1.26), P <0.000 01]。两年内复发率[RR 0.31, 95% CI (0.19-0.51), P <刺激穴位组患儿CVA水平与咳嗽持续时间[MD = - 2.42, 95% CI (-3.75, - 1.09), P = 0.0004]均显著低于对照组。此外,刺激穴位可降低IgE [SMD = - 0.75, 95% CI (-1.21, - 0.30), P = 0.001]和EOS [SMD = - 0.36, 95% CI (-0.92,0.21), P =0.22]水平。结论穴位刺激对儿童CVA治疗有积极作用,是一种相对安全的治疗方法。然而,需要更多有更多有用指标的随机对照试验来证实目前的发现。
Effect and safety of stimulating acupoints in children with cough variant asthma: A Meta-analysis
OBJECTIVE
To evaluate the efficacy and safety of stimulating acupoints in subjects with childhood cough variant asthma (CVA).
METHODS
A Meta-analysis of randomized controlled trials (RCTs) about the comparison between acupoint sticking therapy and non-acupoint sticking therapy for childhood CVA was conducted. The trials’ quality and risk bias were assessed using the Cochrane Handbook tool. Odds ratio (OR) or risk ratio (RR) with 95% confidence intervals (CIs), mean differences (MDs) or standardized mean differences (SMDs) of a random-effects model were calculated. Heterogeneity was assessed by P value and I2 statistics.
RESULTS
Thirteen studies were included in our review, indicating that the total effective rate of stimulating-acupoint group is better than that of control group [RR 1.19, 95% CI (1.13-1.26), P < 0.000 01]. The recurrence rate in two years [RR 0.31, 95% CI (0.19-0.51), P < 0.000 01] and cough duration [MD = −2.42, 95% CI (–3.75, −1.09), P = 0.0004] of childhood CVA in stimulating-acupoint group were significantly lower than those in control group. Besides, stimulating acupoints can reduce the level of IgE [SMD = −0.75, 95% CI (–1.21, −0.30), P = 0.001] and EOS [SMD = −0.36, 95% CI (–0.92,0.21), P =0.22].
CONCLUSION
Our findings suggest that stimulating acupoints had positive effects on childhood CVA and was relatively safe treatment. However, more RCTs with more useful indicators are warrant to confirm the current findings.
期刊介绍:
Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.