急性心肌梗死后的短期生存:一项前瞻性观察研究

M. Aryaie, F. Bakhsha, Seyyed Yaghub Jafari, Z. Yousefi, A. Heidari, Z. Esmaeili, S. Sobhani, Shima Aghili
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摘要

简介:调查伊朗北部Gorgan地区与经典危险因素存在相关的首次急性心肌梗死(AMI)后28天生存率和治疗方式。材料和方法:我们的队列包括2010 - 2013年因AMI住院的所有患者。收集了人口统计学、预防性药物和典型冠状动脉危险因素的数据。数据分析采用Kaplan-Meier检验和log rank检验。建立Cox比例风险模型,综合考虑其他变量估算相对风险。结果:男性和女性的中位年龄分别为58岁和64岁;糖尿病的发生率分别为52.5和24.5。在最终模型中,女性的存活率较差。在调整后的模型中检测到法尔斯人或非波斯人以及未服用他汀类药物的人的死亡发生率过高。结论:服用他汀类药物的患者生存率更高,这表明他汀类药物可能是一种有益的治疗方式,非波斯种族需要被视为早期筛查项目的高危人群。尽管有其他一些研究发现,即使在考虑了年龄和合并症的情况下,女性AMI后的预后也较差。
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The short-term survival following acute myocardial infarction: A prospective observational study
Introduction: To investigate 28 days survival rate following first acute myocardial infarction (AMI) associated with the presence of classical risk factors and treatment modalities in Gorgan, north of Iran. Materials and methods: Our cohort including all patients hospitalized due to AMI from 2010 to 2013. Data were collected on demographic, prophylactic drugs and classical coronary risk factors. Data were analyzed using Kaplan-Meier and log rank tests. Cox proportional hazard model was built to estimate relative risk by taking into account other variables. Results: Median age of subjects was 58 and 64 for men and women, respectively; moreover, the occurrence of diabetes was 52.5 and 24.5 for them. A poorer outcome was detected in survival rate for women in the final model. Excess death occurrence in Fars or nonPersian ethnicity, and those who were not prescribed statin was detected in the adjusted model. Conclusion: A better survival rate for those who were prescribed statin suggest that it could be beneficial in treatment modality and non-Persian ethnicities needed to be considered as a group of at risk for earlier screening programs. In spite of some other studies a poorer outcome following AMI for women was found even after taking into account age and comorbidity.
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