Superficial epidermolytic ichthyosis in a neonate

Superficial epidermolytic ichthyosis (SEI) is a rare blistering disorder, manifesting as blisters and hyperkeratosis. It has characteristic histopathological features, hyperkeratosis, vacuolar degeneration of the granular layer, and subcorneal split. Clinically, peeling skin syndrome and epidermolytic ichthyosis can mimic SEI. Therefore, a skin biopsy is essential to diagnose this rare genetic condition. Here, we are reporting a rare case of SEI in neonates presented with peeling of the skin.