肿瘤血管VS肿瘤细胞靶向:了解使用功能性纳米颗粒治疗癌症的最新趋势

Q2 Pharmacology, Toxicology and Pharmaceutics OpenNano Pub Date : 2023-05-01 DOI:10.1016/j.onano.2023.100136

Nahid S Awad , Najla M Salkho , Waad H Abuwatfa , Vinod Paul , Nour M AlSawaftah , Ghaleb A Husseini

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引用次数: 2

摘要

利用纳米颗粒(NPs)将药物递送到肿瘤中，在促进抗肿瘤药物靶向递送以提高其效率同时降低相关的全身毒性方面显示出良好的潜力。本文综述了不同类型的NPs和肿瘤微环境(TME)的生理特征，以及将药物安全递送到特定病变的机制。本文综述了以肿瘤血管为靶点的NPs与以癌细胞为靶点的NPs的原理和最新进展，以及它们与TME的相关性。我们讨论了每种靶向药物传递机制的优点和局限性，以及旨在最大化其潜力的未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment

Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. This review highlights the different types of NPs and the physiological characteristics of the tumor microenvironment (TME), and the mechanisms undertaken to safely deliver drugs to specific lesions. We review the principles and latest developments in the field of targeted NPs designed to target tumor vasculature compared to those designed to target cancer cells and their correlation with the TME. We discuss the advantages and limitations of each targeted drug delivery mechanism and future directions aiming to maximize their potential.

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来源期刊

OpenNano Medicine-Pharmacology (medical)

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

50 days

期刊介绍： OpenNano is an internationally peer-reviewed and open access journal publishing high-quality review articles and original research papers on the burgeoning area of nanopharmaceutics and nanosized delivery systems for drugs, genes, and imaging agents. The Journal publishes basic, translational and clinical research as well as methodological papers and aims to bring together chemists, biochemists, cell biologists, material scientists, pharmaceutical scientists, pharmacologists, clinicians and all others working in this exciting and challenging area.