一种便携式、真空操作、纯机械抽吸粪便治疗慢性肛裂的装置

IF 0.8 4区 医学 Q4 ENGINEERING, BIOMEDICAL Journal of Medical Devices-Transactions of the Asme Pub Date : 2022-11-15 DOI:10.1115/1.4056251
Riaz Ur Rehman Mohammed, Vedad Bassari, Richard Rasmussen, B. Terry
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引用次数: 0

摘要

肛裂是一种常见的肛门直肠问题,影响所有年龄组的男性和女性。它从急性期发展而来,表现为阳极层的线性或椭圆形撕裂,由于愈合不良,可能发展到更复杂的慢性期。常规排便会导致阳极皮过度拉伸,加深疤痕,形成一个正反馈回路,阻止裂缝愈合。现有的治疗方法可能是侵入性的、昂贵的,并且可能引起副作用。在这里,我们提出了一种新型的真空操作机械装置,通过抽吸提取粪便。该装置旨在通过协助排便来解决阳极拉伸的问题。该装置在直肠台式模型上进行了体外测试,并在猪身上进行了体内测试。体外测试表明,该装置可以保持真空12小时,泄漏量可以忽略不计。此外,该装置可以以32mL/s的流速提取模拟人类粪便。在猪身上进行的体内测试表明,该装置没有对直肠壁造成任何创伤,因此证明了其安全性。我们的研究结果突出了这种新型平台的潜力,可以避免阳极皮肤拉伸的问题,提高肛裂的愈合率。
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A Portable, Vacuum-Operated, and Purely Mechanical Device for Extracting Feces by Suction to Cure Chronic Anal Fissures
An anal fissure is a common anorectal problem that affects men and women of all age groups. It develops from an acute phase that presents as a linear or oval tear in the anoderm and may progress to a more complex chronic stage due to poor healing. Routine defecation causes overstretching of the anoderm and deepens the scar, setting up a positive feedback loop that keeps the fissure from healing. Existing treatments can be invasive, expensive, and may induce side effects. Here we present a novel vacuum-operated mechanical device to extract feces via suction. The device is designed to solve the problem of anodermal stretching by assisting in defecation. The device was tested in vitro on a benchtop model of the rectum and in vivo on pigs. In vitro tests showed that the device could hold a vacuum for 12 h with negligible leakage. Further, the device could extract simulated human feces at a flowrate of 32 mL/s. In vivo tests on pigs showed that the device did not cause any trauma to the rectal wall, thus demonstrating its safety. Our results highlight the potential of this novel platform to circumvent the problem of anodermal stretching and improve the healing rate of anal fissures.
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来源期刊
CiteScore
1.80
自引率
11.10%
发文量
56
审稿时长
6-12 weeks
期刊介绍: The Journal of Medical Devices presents papers on medical devices that improve diagnostic, interventional and therapeutic treatments focusing on applied research and the development of new medical devices or instrumentation. It provides special coverage of novel devices that allow new surgical strategies, new methods of drug delivery, or possible reductions in the complexity, cost, or adverse results of health care. The Design Innovation category features papers focusing on novel devices, including papers with limited clinical or engineering results. The Medical Device News section provides coverage of advances, trends, and events.
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