韩国儿童和青少年高尿酸血症患病率及其与代谢综合征和心脏代谢危险因素的关联:基于2016-2017年韩国国家健康与营养检查调查的分析

Jung Hyun Lee
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引用次数: 23

摘要

目的调查韩国儿童和青少年高尿酸血症的患病率及其与代谢综合征(MetS)和心脏代谢危险因素(CMRFs)的关系。方法横断面调查采用第七次韩国国民健康与营养检查调查(2016-2017)的数据;包括1256名年龄在10-18岁的男性和女性。高尿酸血症定义为10-11岁(男女)血清尿酸水平为bbb6.6 mg/dL, 12-18岁男性为>7.7 mg/dL, 12-18岁女性为>5.7 mg/dL。MetS是根据国际糖尿病联合会的标准定义的。采用Logistic回归分析高尿酸血症相关危险因素。结果高尿酸血症患病率为9.4%(男性8.4%;女性,10.5%)(P<0.281)。在多变量分析(模型1)中调整了社会人口因素和健康行为后,MetS高尿酸血症的优势比(OR)为3.05(95%可信区间[CI], 1.17-7.92;P = 0.022)。在模型1加上肥胖和所有MetS成分(模型2)中调整相同的变量后,只有腹部肥胖具有显著性,高尿酸血症的OR为3.38 (95% CI, 1.72-6.63;P<0.001)在对模型1中的相同变量加上体重指数(BMI) z分数和除腹部肥胖(模型3)外的所有MetS成分进行调整后,只有BMI z分数具有显著性,高尿酸血症的OR为1.59 (95% CI, 1.34-1.89;P < 0.001)。结论MetS、腹部肥胖和BMI z评分是与韩国儿童和青少年高尿酸血症显著相关的CMRFs。因此,肥胖或MetS患者应注意高尿酸血症。
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Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey
Purpose Investigating the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents. Methods This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016–2017); 1,256 males and females aged 10–18 years were included. Hyperuricemia was defined as serum uric acid levels were >6.6 mg/dL at 10–11 years of age (both sexes), >7.7 mg/dL for males at 12–18 years of age and >5.7 mg/dL for females at 12–18 years of age. MetS was defined by the International Diabetes Federation criteria. Logistic regression analysis was used to analyze hyperuricemia-associated risk factors. Results The prevalence of hyperuricemia was 9.4% (male, 8.4%; female, 10.5%) (P<0.281). After adjusting for sociodemographic factors and health behaviors in multivariate analysis (model 1), the odds ratio (OR) for hyperuricemia of MetS was 3.05 (95% confidence interval [CI], 1.17–7.92; P=0.022). After adjusting for the same variables in model 1 plus obesity and all MetS components (model 2), only abdominal obesity was significant, and the OR for hyperuricemia was 3.38 (95% CI, 1.72–6.63; P<0.001) After adjusting for the same variables in model 1 plus body mass index (BMI) z scores and all MetS components except abdominal obesity (model 3), only BMI z scores was significant, and the OR for hyperuricemia was 1.59 (95% CI, 1.34–1.89; P<0.001). Conclusion MetS, abdominal obesity, and BMI z scores were CMRFs significantly associated with hyperuricemia in Korean children and adolescents. Therefore, attention should be paid to hyperuricemia in patients with obesity or MetS.
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审稿时长
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期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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