免疫检查点抑制剂治疗癌症挽救性化疗的疗效和安全性

Pub Date : 2019-05-09 DOI:10.2217/lmt-2019-0001

M. Tone, T. Izumo, Nobuyasu Awano, N. Kuse, M. Inomata, Tatsunori Jo, Hanako Yoshimura, S. Miyamoto, H. Kunitoh

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引用次数: 14

摘要

目的：评估免疫检查点抑制剂（ICI）与挽救性化疗疗效的关系，以及挽救性化疗的安全性。患者和方法：对18例晚期NSCLC患者进行回顾性分析。我们评估了挽救性化疗的总有效率和不良事件。结果：对挽救性化疗的总有效率为33.3%，ICI应答者明显高于无应答者（分别为66.7%和16.7%，p=0.03）。挽救性化疗不良事件发生率为55.6%。结论：挽救性化疗疗效与ICI前相似。此外，挽救性化疗的安全性良好。

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Treatment effect and safety profile of salvage chemotherapy following immune checkpoint inhibitors in lung cancer

Aim: To assess the relationship of treatment effects between immune checkpoint inhibitor (ICI) and salvage chemotherapy, with the safety profile of salvage chemotherapy. Patients & methods: 18 patients with advanced NSCLC treated using salvage chemotherapy following ICI treatment were retrospectively included. We assessed the overall response rate to and adverse events of salvage chemotherapy. Results: The overall response rate to salvage chemotherapy was 33.3% and that of ICI responders was significantly higher than that of ICI nonresponders (66.7 vs 16.7%, respectively, p = 0.03). The incidence rate of adverse events to salvage chemotherapy was 55.6%. Conclusion: The efficacy of salvage chemotherapy was similar to that preceding ICI. Moreover, the safety of salvage chemotherapy was good.

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