一氧化氮细胞信号转导与乳腺癌的研究进展

Cui-Cui Zhao, J. Chen, Yan Liu, Chuan-Gui Zhang
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摘要

癌症是女性最常见的恶性肿瘤之一,其发病率逐年上升,是女性特别是年轻女性最重要的死亡原因之一。研究影响癌症发展和进展的相关细胞信号传导,有助于预防癌症的发生,减缓癌症的进展,改善患者的预后。一氧化氮(NO)是一种信号分子。许多研究表明,NO的产生和表达与癌症密切相关。氮相关细胞信号传导对癌症的发生发展有显著影响。然而,对NO与乳腺癌症相关细胞信号传导之间关系的理解还有待进一步提高。本文综述了近年来在癌症中NO-相关细胞信号传导的相关研究,以期加深对癌症发生发展的认识。关键词:一氧化氮;癌症;细胞信号转导
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Research progress in cellular signal transduction of nitric oxide and breast cancer
Breast cancer is one of the most common malignant tumors in women, and its incidence has increased year by year, which is one of the most important causes of death among women, especially young women. Studying related cell signal transduction that affects the development and progression of breast cancer can help prevent the occurrence of breast cancer, slow down the cancer progression and improve the prognosis of patients. nitric oxide (NO) is a kind of signaling molecule. Many studies have shown that the production and expression of NO are closely related to breast cancer. NO-related cell signal transduction significantly affects the occurrence and development of breast cancer. However, the understanding of the relationship between NO and breast cancer associated cell signal transduction needs to be further improved. In this paper, the related studies on NO-related cellular signal transduction in breast cancer were reviewed with a view to improving the understanding of the development and progression of breast cancer. Key words: Nitric oxide; Breast cancer; Cell signal transduction
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