Coexistence of Crohn’s Disease and Systemic Lupus Erythematosus with Lupus Nephritis : About Two Cases

Systemic lupus erythematosus (SLE) is a chronic multisystem inflammatory disease, known as a prototype for autoimmune disease [1,2]. It is usually associated with other autoimmune and dysimmune diseases. Inflammatory bowel disease (IBD) is one of the specific dysimmune diseases of the intestine with extraintestinal involvements and with environmental factors and genetic predisposition [3]. IBD is a chronic recurrent disease comprised of two major phenotypes, Crohn’s disease (CD) and ulcerative colitis [4]. The coexistence of SLE and CD in the same patient is extremely rare (<0.4%) [5]. Even rarer is the association between lupus nephritis (LN) and CD, with only two cases reported to date [6,7]. A review study corroborated that SLE was associated with comorbid CD (OR 2.23) [8]. We communicate herein two cases of patients, ones with SLE who was diagnosed CD colitis and the other with CD who was diagnosed SLE. Case presentation 1