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Epidemiological Characteristics of Hepatitis B Positive Patients in Oman between 2009 and 2019: A Retrospective Cohort Study 2009 - 2019年阿曼乙型肝炎阳性患者的流行病学特征:一项回顾性队列研究
Pub Date : 2021-08-09 DOI: 10.33552/ajgh.2021.03.000553
S. Awaidy
The prevalence of chronic hepatitis in Oman was estimated to 2-7% prior to the introduction of vaccination. However, HBV remains a major concern among unvaccinated individuals, especially older adults. Objective: The study aim is to describe the epidemiological characteristics of HBV positive patients at a specialized liver clinic at the Armed Forces Hospital, between January 2009 and December 2019. A retrospective cohort study was undertaken, and secondary data were obtained from electronic medical records. Results: 593 patients with positive HBV serology were identified. Fifty-nine percent of patients were male, with a mean age of 42 years (SD: 10.05) compared to females (43 years, SD: 10.70). Eighty-five percent (492/580) of the patients were treatment naïve. Eighty-eight percent showed detectable HBV viremia. The median level of HBV DNA among chronic hepatitis BV patients who are HBeAg-positive was significantly higher: 1 884 847 IU/ml (IQR: 81662-486924145), as compared to the rest of chronic hepatitis BV patients: 339 IU/ml (IQR: 33.5-3366). Elevated ALT (≥ 40 IU/ ml) was found in 29% of the patients. liver abnormalities were detected by ultrasound in 28% (165) of patients. Treatment was introduced in 15% of patients. Conclusion: The majority of HBV patients were seronegative for HB-Ag and were born before the vaccination era. Therefore, these patients with hepatitis B in dormancy do not need treatment, but regular monitoring and follow-up.
在接种疫苗之前,阿曼的慢性肝炎患病率估计为2-7%。然而,HBV仍然是未接种疫苗的人,尤其是老年人的主要担忧。目的:本研究旨在描述2009年1月至2019年12月期间武装部队医院肝脏专科诊所HBV阳性患者的流行病学特征。进行了一项回顾性队列研究,并从电子医疗记录中获得了次要数据。结果:共发现593例HBV血清学阳性患者。59%的患者是男性,平均年龄为42岁(SD:10.05),而女性(43岁,SD:10.70)。85%(492/580)的患者治疗幼稚。88%的患者表现出可检测的HBV病毒血症。HBeAg阳性的慢性乙型肝炎患者的HBV DNA中位水平显著较高:1 884 847 IU/ml(IQR:88162-486924145),而其他慢性乙型肝炎病例的HBV DNA中位数为339 IU/ml(IQ R:33.5-3366)。29%的患者ALT升高(≥40 IU/ml)。28%(165)的患者经超声检查发现肝脏异常。15%的患者接受了治疗。结论:大多数HBV患者血清HB-Ag均为阴性,且出生于疫苗接种时代之前。因此,这些处于休眠状态的乙肝患者不需要治疗,而是需要定期监测和随访。
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引用次数: 0
Use of Silimarin in the Treatment of Non-Alcoholic Fatty Liver Disease (Nafld) Silimarin在治疗非酒精性脂肪肝(Nafld)中的应用
Pub Date : 2021-07-15 DOI: 10.33552/ajgh.2021.03.000552
Sander Bq
Non-alcoholic hepatic steatosis is characterized by steatosis and necroinflammation, with or without centrilobular fibrosis [1], in cases where the deposit of lipids in hepatocytes exceeds 5% of the total weight of the liver and there is no other causes of hepatic involvement [2]. Therefore, in its diagnosis it is necessary to exclude viral hepatitis, use of drugs that promote parenchymal alterations, autoimmune hepatitis, hemochromatosis, Wilson’s disease, or significant alcohol consumption above 30 g daily for men, and 20 g daily for women [3]. The main risk factors for its development are the components of the metabolic syndrome, weight gain, insulin resistance, hypertension, and hyperlipidemia [1]. These risk factors suggest reasons for the increased prevalence of nonalcoholic hepatic steatosis in the world, probably as a result of changes in lifestyle and eating habits, with increasing consumption of carbohydrates, also contributing to the evolution of diagnostic methods for the disease. This prevalence, although the numbers may vary between authors, is currently estimated at 20% to 40% in the world population, and this high incidence has become a source of concern for health professionals [3-6].
非酒精性肝脂肪变性的特征是脂肪变性和坏死性炎症,伴有或不伴有小叶中心纤维化[1],在肝细胞中脂质沉积超过肝脏总重量的5%且没有其他肝脏受累原因的情况下[2]。因此,在诊断中,有必要排除病毒性肝炎、使用促进实质改变的药物、自身免疫性肝炎、血色素沉着症、Wilson病,或男性每天饮酒量超过30克,女性每天饮酒量高于20克[3]。其发展的主要危险因素是代谢综合征的组成部分、体重增加、胰岛素抵抗、高血压和高脂血症[1]。这些风险因素表明了世界上非酒精性肝脂肪变性患病率增加的原因,可能是生活方式和饮食习惯的改变,碳水化合物的消耗增加,也有助于该疾病诊断方法的发展。尽管作者之间的数字可能有所不同,但目前估计世界人口中这种患病率为20%至40%,这种高发病率已成为卫生专业人员关注的问题[3-6]。
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引用次数: 0
Aftermath Pandemic Challenges for the Cancer Service Provision, The Need for A Fitting Strategy: A Standpoint from the UK 癌症服务提供的流行病后挑战,需要一个合适的战略:来自英国的观点
Pub Date : 2021-06-17 DOI: 10.33552/ajgh.2021.03.000551
Y. Viswanath
Soon after the 1st lockdown was imposed in the UK on March 27, 2020, all elective activity surgical and endoscopic stopped in James Cook University Hospital, Cleveland County in North England. It was almost a standstill due to fear of the unknown and senior upper GI oncology surgeon thinking how one could not stop cancer-related care, especially extensive major cancer surgeries such as esophagectomy and gastrectomy. Approach with common sense, untold braveness with available guidance and safety kit, surgeries continued despite the risk to the operating surgical team and the patient. The UK health ministry’s announcement was candid and stated the cancer care should continue, and one must not deny timely access to the treatment. Furthermore, potential patients’ reluctance to attend hospitals, reduced access to primary care, delayed referrals, and a few other factors impacted deferred diagnosis. The estimated loss could amount to 60,000 life-years plus in the next decade in the UK [1].
2020年3月27日,英国实施第一次封锁后不久,位于北英格兰克利夫兰县的詹姆斯·库克大学医院停止了所有选择性手术和内镜活动。由于担心未知和资深上消化道肿瘤外科医生认为无法停止癌症相关护理,尤其是广泛的癌症大手术,如食管切除术和胃切除术,这几乎是一场停滞。有了常识,有了可用的指导和安全工具包,尽管手术团队和患者面临风险,但手术仍在继续。英国卫生部的声明是坦率的,并表示癌症治疗应该继续,不能拒绝及时获得治疗。此外,潜在患者不愿去医院就诊、获得初级保健的机会减少、转诊延迟以及其他一些因素影响了延迟诊断。据估计,在英国,未来十年的损失可能达到60000多岁[1]。
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引用次数: 0
New Paradigms in the Treatment of Metastatic Hepatocarcinoma: Case Report 转移性肝癌治疗的新模式:病例报告
Pub Date : 2021-06-09 DOI: 10.33552/ajgh.2021.02.000550
E. Melo
of The results of the phase III study, IMbrave 150, which compared atezolizumab plus bevacizumab versus sorafenib, represented an important advance in the first-line treatment. We report a clinical case of a 78-year-old patient with metastatic hepatocarcinoma, who underwent first-line treatment with the combination of atezolizumab and bevacizumab. After 3 treatment cycles, there was a complete response in the lung and a partial response in the liver, opening the discussion about the possibility of considering at some point the local treatment of the liver in the face of tumor downstaging.
III期研究IMbrave 150的结果比较了atezolizumab +贝伐单抗与索拉非尼,代表了一线治疗的重要进展。我们报告一个78岁的转移性肝癌患者的临床病例,他接受了阿特唑单抗和贝伐单抗联合一线治疗。3个治疗周期后,肺部出现完全缓解,肝脏出现部分缓解,这开启了在肿瘤降期时考虑肝脏局部治疗的可能性的讨论。
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引用次数: 0
Crohn’s Disease: A Curable Disease Held Hostage? 克罗恩病:一种可治愈的疾病?
Pub Date : 2021-06-09 DOI: 10.33552/ajgh.2020.02.000550
E. Melo
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引用次数: 1
Ramzan for Patients with Chronic Liver Disease 拉姆赞治疗慢性肝病
Pub Date : 2021-05-07 DOI: 10.33552/ajgh.2020.02.000548
Z. Majid
With the holy month of Ramzan fast approaching us, Muslim’s from all around the world would be engaged in various religious activities including fasting. Ramzan is the 9th month of the Islamic calendar and during which fasting is obligatory for all muslims. During a fast a Muslim not only abstains themselves from food and water but also from smoking and oral medications [1]. A typical fast last around 12-18 hours [2] At present the impact of fasting on patients with chronic liver disease regardless of its etiologic is scarce. Here we wish to highlight the effects of fasting in the month of ramzan and the precautionary measures that need to be taken in this month in patients diagnosed with chronic liver disease (regardless of its etiology). Cirrhotics are particularly at risk of protein energy malnutrition (PEM), upper gastrointestinal bleed, worsening of their liver functions along with encephalopathy and discontinuation of their medications during fasting [3]. Along with this, fasting in the tropics or during the summer season may place these patients at risk of renal dysfunction [3]. Generally, it is recommended that patients having Child Pugh score C (CPS) cirrhosis should avoid fasting [3].
随着斋月的临近,来自世界各地的穆斯林将进行包括斋戒在内的各种宗教活动。斋月是伊斯兰历法的第九个月,在此期间,所有穆斯林都必须禁食。在斋戒期间,穆斯林不仅不吃不喝,而且不吸烟,不服用药物。典型的禁食持续约12-18小时,目前,禁食对慢性肝病患者的影响很少,无论其病因如何。在这里,我们希望强调斋月禁食的影响,以及诊断为慢性肝病的患者(无论其病因如何)在这个月需要采取的预防措施。肝硬化患者尤其有发生蛋白质能量营养不良(PEM)、上消化道出血、肝功能恶化并伴有脑病和禁食期间停药的风险。与此同时,在热带地区或夏季禁食可能会使这些患者面临肾功能不全的风险。一般建议Child Pugh评分C (CPS)肝硬化患者避免空腹。
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引用次数: 0
Recurrence of Upper Gastrointestinal Hemorrhage in Sclerotherapy X Elastic Ligature: Systematic Review X弹性结扎硬化治疗后上消化道出血复发:系统回顾
Pub Date : 2021-04-16 DOI: 10.33552/ajgh.2020.02.000547
Sander Bq
s: To compare, through a systematic review, the recurrence of upper digestive hemorrhage in the techniques of sclerotherapy and The most relevant studies in the MedLine, Bireme and Scielo databases were analyzed. The search strategy used the following keyword combinations: (“High Digestive Hemorrhage, Sclerotherapy, Elastic Bandage”). Results: There were 9 studies selected from the crossword of the keywords, and of these, only 6 were used in the studies after applying the Randomized Controlled Trial and Clinical Trials filters. Conclusion: There is no definite consensus on which technique - sclerotherapy or elastic ligation - could be associated with a lower risk of recurrence in cases involving upper gastrointestinal bleeding. The literature shows advantages both in the technique of sclerotherapy and in the technique of elastic ligation, and in general, it is nowadays observed that the technique considered gold standard for these cases is the technique of elastic ligation, although many professionals still opt for sclerotherapy, especially in surgical intervention in pediatric patients.
s: 通过系统回顾,比较硬化治疗技术中上消化道出血的复发和MedLine、Bireme和Scielo数据库中最相关的研究。搜索策略使用了以下关键词组合:(“高消化道出血、硬化疗法、弹力绷带”)。结果:从关键词的填字游戏中选择了9项研究,其中只有6项在应用随机对照试验和临床试验过滤器后用于研究。结论:在涉及上消化道出血的病例中,哪种技术(硬化治疗或弹性结扎)可以降低复发风险,目前还没有明确的共识。文献显示了硬化治疗技术和弹性结扎技术的优势,总的来说,目前观察到,这些病例的黄金标准技术是弹性结扎技术,尽管许多专业人员仍然选择硬化治疗,尤其是在儿科患者的手术干预中。
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引用次数: 0
Two Nobel Prizes that Both Fight Starvation, Helicobacter Pylori and WFP 两项诺贝尔奖同时对抗饥饿、幽门螺杆菌和世界粮食计划署
Pub Date : 2021-04-06 DOI: 10.33552/ajgh.2021.02.000546
T. Midtvedt
In 2020 the Nobel Peace prize was awarded to World Food Program (WFP) due to their important job in distributing food and fighting starvation all over the world. Fifteen years earlier the Nobel Prize in Physiology or Medicine was awarded for the discovery of the bacterium Helicobacter pylori. This bacterium – in its own way actually also helps fight starvation. In 2018 it was estimated that across the world 821 million people were going hungry -124 million acutely so [1]. In order to reduce starvation and treat malnutrition WFP for many years have delivered so called food baskets. The actual size and composition of the food basket is closely tailored to local preferences, demographic profile, climate conditions, local coping capacity and existing levels of malnutrition and disease [2]. In 1982 Robin Warren and Barry J. Marshall unexpectedly discovered that inflammation in the stomach (gastritis) as well as ulceration of the stomach or duodenum (peptic ulcer disease) could be the result of an infection caused by a bacterium. In 2005 they jointly were awarded the Nobel Prize in Physiology or Medicine. The infection could be treated by antibiotics. The bacterium was named Helicobacter pylori (H. pylori).
2020年,诺贝尔和平奖被授予世界粮食计划署(WFP),因为他们在世界各地分发食物和抗击饥饿方面做出了重要贡献。15年前,诺贝尔生理学或医学奖被授予幽门螺杆菌的发现。这种细菌实际上也以自己的方式帮助对抗饥饿。据估计,2018年全球有8.21亿人处于饥饿状态,其中1.24亿人处于严重饥饿状态。为了减少饥饿和治疗营养不良,世界粮食计划署多年来一直提供所谓的粮食篮。粮食篮子的实际规模和组成是根据当地的喜好、人口状况、气候条件、当地的应对能力和现有的营养不良和疾病水平密切调整的。1982年,罗宾·沃伦(Robin Warren)和巴里·j·马歇尔(Barry J. Marshall)出人意料地发现,胃炎(胃炎)以及胃或十二指肠溃疡(消化性溃疡疾病)可能是细菌感染的结果。2005年,他们共同获得了诺贝尔生理学或医学奖。这种感染可以用抗生素治疗。这种细菌被命名为幽门螺杆菌(h.p ylori)。
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引用次数: 0
Fodmap’s Restricted Diet in Patients with Irritable Gut Syndrome: A Systematic Review Fodmap对肠易激综合征患者的限制性饮食的系统评价
Pub Date : 2021-03-15 DOI: 10.33552/AJGH.2020.02.000545
Sander Bq
To verify the The most and were (National and SciELO as In order to select the studies with the greatest scientific we and review studies. The search strategy the following keywords: “irritable bowel syndrome” and “FODMAP’s restricted diet”. To identify the designs of the studies, the following terms were used: clinical trials. Results: Initially, 117 studies were identified involving irritable bowel syndrome and the Foodmap diet. However, after applying the Clinical Trials filters, 10 studies were found. After reading the articles found and excluding them from the abstracts, 5 articles were selected involving the theme for analysis and inclusion in the scope of this review. Conclusion: The restricted diet in FODMAPs proved to be very effective in improving general and specific symptoms of irritable bowel syndrome, especially abdominal pain, bloating and diarrhea. compared to the positive control and may be better tolerated in individuals with IBS. Further research should be con-ducted to better understand the GI tolerance of low FODMAP ONS in individuals with IBS.
为了选出最具科学性的研究,并对研究进行综述,我们对国家和SciELO的研究进行了验证。搜索策略如下关键词:“肠易激综合征”和“FODMAP的限制饮食”。为了确定研究的设计,使用了以下术语:临床试验。结果:最初,117项研究被确定涉及肠易激综合征和Foodmap饮食。然而,在应用临床试验过滤器后,发现了10项研究。在阅读了发现的文章并将其从摘要中排除后,选择了5篇涉及该主题的文章进行分析并纳入本综述的范围。结论:FODMAPs的限制饮食对改善肠易激综合征的一般和特定症状,特别是腹痛、腹胀和腹泻非常有效。与阳性对照相比,在肠易激综合征患者中耐受性更好。应该进行进一步的研究,以更好地了解肠易激综合征患者对低FODMAP ONS的GI耐受性。
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引用次数: 0
Invasive Cancer of the Colon with Gastric Metastasis 侵袭性结肠癌伴胃转移
Pub Date : 2021-03-15 DOI: 10.33552/AJGH.2020.02.000544
A. Gligorievski
We present case of metastatic from cancer. Computed tomography (CT) indicated primary colon cancer, but also revealed the presence of cancer in the region of the gastric greater curvature and gastric antrum. With the progression of primary cancer and the creation of an extraluminal tumor mass, the process progresses in the manner that the primary transversal colon tumor merges into the metastatic deposit located in the stomach. The patient underwent subtotal gastrectomy and D2 lymphadenectomy, as well as partial resection of the transversal colon, thus the tumor mass of the stomach and the one in the transversal colon being removed in a single act. Pathohistological analysis of the tumor mass and immunohistochemical tests revealed a primary neoplastic infiltrative process in the colon metastasizing into the stomach.
我们报告一例癌症转移。计算机断层扫描(CT)显示原发性结肠癌,但也显示胃癌存在于胃大弯曲和胃窦区域。随着原发性癌症的发展和腔外肿瘤肿块的形成,这一过程的进展方式是原发性横向结肠肿瘤合并到位于胃的转移沉积物中。患者行胃次全切除术和D2淋巴结切除术,并部分切除横结肠,一次切除了胃肿瘤和横结肠肿瘤。肿瘤的病理组织学分析和免疫组织化学检查显示原发性肿瘤浸润过程在结肠转移到胃。
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引用次数: 1
期刊
Academic journal of gastroenterology & hepatology
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