纳米复合材料作为药物载体的潜力及其未来前景

IF 3.1 3区 化学 Q2 POLYMER SCIENCE Polymer Bulletin Pub Date : 2023-09-07 DOI:10.1007/s00289-023-04987-z
Malika Gupta, Rajni Bala, Reecha Madaan, Samrat Chauhan, Rakesh Chawla, Jasleen Kaur, Javad Sharifi-Rad, Daniela Calina
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引用次数: 0

摘要

近十年来,纳米复合材料的研究与开发已成为一个备受关注的科学领域。纳米复合材料由聚合物和无机固体的混合物组成,两者结合形成一种异质/混合材料。它们是一种添加到纳米粒子中的基质,用于增强机械性能和其他性能,如电气、物理和光学性能,然后进行尺寸重新定位。这些基质在纳米复合材料结构中的添加浓度约为 0.5-2%。结构、组成、界面相互作用和成分或任何专属特性的微小变化都可能导致产品的产生。在制备方法方面,生物聚合物和无机基质在原位生长和聚合,形成纳米复合材料。由于纳米复合材料的形态特性(如表面和流变特性)可用作药物载体,因此其在生物医学和制药科学领域的应用日益受到关注。本综述旨在讨论纳米复合材料的优缺点、制备方法、类型,以及纳米复合材料作为可控和靶向给药系统的效用、用于给药抗癌、抗菌、抗炎、抗糖尿病和心血管药物的前景。
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Unfolding the potential of nanocomposites as drug carriers and their future scenarios

Research and development of nanocomposites have become a scientific field of interest in the last decade. These are formed from mixtures of polymers and inorganic solids that combine to form a heterogeneous/hybrid material. They are a type of matrix added to nanoparticles to enhance mechanical properties and additional properties such as electrical, physical and optical properties, followed by size repositioning. These matrices are added in a concentration of about 0.5–2% in the nanocomposite structure. Minor changes in structure, composition, interfacial interactions and components or any exclusive properties may instigate the product. Regarding the method of preparation, the biopolymer and inorganic matrix are grown and polymerized in situ to create a nanocomposite material. The use of nanocomposites has increased its share of interest in biomedical and pharmaceutical sciences, as they can be used as a medicinal carrier due to their morphological properties, such as their surface and rheological properties. This comprehensive review aims to discuss the advantages and disadvantages of nanocomposites, their method of preparation, their types and the utility of nanocomposites as a controlled and targeted delivery system, their use to deliver anticancer, antimicrobial, anti-inflammatory, antidiabetic and cardiovascular drugs, including their prospects.

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来源期刊
Polymer Bulletin
Polymer Bulletin 化学-高分子科学
CiteScore
6.00
自引率
6.20%
发文量
0
审稿时长
5.5 months
期刊介绍: "Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad. "Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."
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