机器人浇铸制备的孔分级生物活性玻璃支架的力学性能

Q1 Materials Science Biomedical Glasses Pub Date : 2019-01-01 DOI:10.1515/bglass-2019-0012
J. Barberi, A. Nommeots-Nomm, E. Fiume, E. Verné, J. Massera, F. Baino
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引用次数: 17

摘要

摘要自从Larry Hench发现45S5 Bioglass®以来,生物活性玻璃作为骨替代材料得到了广泛的研究,近年来,在生产三维支架方面也显示出了巨大的前景。增材制造技术的发展及其在骨组织工程中的应用允许设计和制造具有可控孔隙率的复杂结构。然而,实现坚固且机械可靠的生物活性玻璃支架仍然是一个巨大的挑战。此外,报告对玻璃衍生支架抗压强度以外的其他机械性能进行详尽评估的研究相对较少。本研究工作旨在确定通过自动铸造制造并呈现孔隙率梯度的硅酸盐SiO2-Na2O-K2OMgO-CaO-P2O5玻璃支架的关键力学性能。当在压缩中测试时,这些支架具有6MPa的强度、约340MPa的杨氏模量、93kJ/m3的断裂能和3的威布尔模量,这提供了支架可靠性和再现性的量化。机器人定位是一种合适的制造方法,可以获得具有与人类松质骨相当的良好孔隙率和机械性能的结构,这是骨植入物骨整合的基础。
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Mechanical characterization of pore-graded bioactive glass scaffolds produced by robocasting
Abstract Since the discovery of 45S5 Bioglass® by Larry Hench, bioactive glasses have been widely studied as bone substitute materials and, in more recent years, have also shown great promise for producing three-dimensional scaffolds. The development of additive manufacturing techniques and their application in bone tissue engineering allows the design and fabrication of complex structures with controlled porosity. However, achieving strong and mechanically-reliable bioactive glass scaffolds is still a great challenge. Furthermore, there is a relative paucity of studies reporting an exhaustive assessment of other mechanical properties than compressive strength of glass-derived scaffolds. This research work aimed at determining key mechanical properties of silicate SiO2-Na2O-K2OMgO-CaO-P2O5 glass scaffolds fabricated by robocasting and exhibiting a porosity gradient. When tested in compression, these scaffolds had a strength of 6 MPa, a Young’s modulus around 340 MPa, a fracture energy of 93 kJ/m3 and a Weibull modulus of 3, which provides a quantification of the scaffold reliability and reproducibility. Robocasting was a suitable manufacturing method to obtain structures with favorable porosity and mechanical properties comparable to those of the human cancellous bone, which is fundamental regarding osteointegration of bone implants.
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
自引率
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审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
期刊最新文献
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