{"title":"含异常α-氨基酸衍生物的六氢芘的设计与合成","authors":"Sambasivarao Kotha, Vidyasagar Gaikwad, Saima Ansari","doi":"10.1007/s12039-023-02170-5","DOIUrl":null,"url":null,"abstract":"<div><p>We report constrained α-amino acid derivatives containing hexahydro pyrene unit using ethyl isocyanoacetate as a glycine equivalent. The required precursor 1,4,5,8-tetrakis(bromomethyl)naphthalene <b>3</b> was prepared from commercially available naphthalene-1,4,5,8-tetracarboxylic anhydride <b>4</b> in a three-step sequence.</p><h3>Graphical abstract</h3><p>Herein, we have developed a facile synthetic strategy to hexahydro pyrene bearing unusual amino acid derivative through the coupling of 1,4,5,8-tetrakis(bromomethyl)naphthalene with ethyl isocyanoacetate (EICA) as a glycine equivalent.</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"135 2","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design and synthesis of hexahydro pyrene containing unusual α-amino acid derivatives\",\"authors\":\"Sambasivarao Kotha, Vidyasagar Gaikwad, Saima Ansari\",\"doi\":\"10.1007/s12039-023-02170-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We report constrained α-amino acid derivatives containing hexahydro pyrene unit using ethyl isocyanoacetate as a glycine equivalent. The required precursor 1,4,5,8-tetrakis(bromomethyl)naphthalene <b>3</b> was prepared from commercially available naphthalene-1,4,5,8-tetracarboxylic anhydride <b>4</b> in a three-step sequence.</p><h3>Graphical abstract</h3><p>Herein, we have developed a facile synthetic strategy to hexahydro pyrene bearing unusual amino acid derivative through the coupling of 1,4,5,8-tetrakis(bromomethyl)naphthalene with ethyl isocyanoacetate (EICA) as a glycine equivalent.</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>\",\"PeriodicalId\":50242,\"journal\":{\"name\":\"Journal of Chemical Sciences\",\"volume\":\"135 2\",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2023-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Chemical Sciences\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12039-023-02170-5\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Sciences","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s12039-023-02170-5","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Chemistry","Score":null,"Total":0}
Design and synthesis of hexahydro pyrene containing unusual α-amino acid derivatives
We report constrained α-amino acid derivatives containing hexahydro pyrene unit using ethyl isocyanoacetate as a glycine equivalent. The required precursor 1,4,5,8-tetrakis(bromomethyl)naphthalene 3 was prepared from commercially available naphthalene-1,4,5,8-tetracarboxylic anhydride 4 in a three-step sequence.
Graphical abstract
Herein, we have developed a facile synthetic strategy to hexahydro pyrene bearing unusual amino acid derivative through the coupling of 1,4,5,8-tetrakis(bromomethyl)naphthalene with ethyl isocyanoacetate (EICA) as a glycine equivalent.
期刊介绍：
Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.
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