Desquamative interstitial pneumonia in association with chronic necrotizing aspergillosis, a case report and literature review

Desquamative interstitial pneumonia (DIP) is a form of interstitial lung disease that is directly related to smoking. In addition to smoking, other factors have been implicated in its etiology, including: systemic disorders, dangerous materials in the environment, drugs and infectious agents. By reviewing the literature, we find that there are very rare cases that indicate infections as causing DIP. Here the author report on a 58-year-old male who was addict and complained of a dry cough with dyspnea for one month. TBLB was performed and pathology result was consistent with DIP. He received prednisolone 5 mg twice a day, but his symptoms persisted. Open-lung biopsy was performed and it illustrated Aspergillus pneumonia (Chronic necrotizing aspergillosis). He was treated with corticosteroids combined with antifungal agents.