脑出血卒中伴与不伴高血压危象患者认知功能的比较

Mohammad Arianto Satrio Wicaksono, Cep Juli, C. Calista, U. Gamayani, A. Cahyani, P. A. Ong
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摘要

背景:脑出血(ICH)中风的特征是神经功能障碍,由非外伤引起的脑实质或脑室系统内的局灶性血液收集引起。高血压是脑出血的主要危险因素之一。高血压危象是一种更严重的未控制的高血压类型,可加重认知结局。本研究的目的是比较脑出血卒中患者有和没有高血压危象的认知功能。方法:本研究采用回顾性比较分析研究,并结合2020年8月至11月的病例对照研究。收集了2019年入住万隆哈桑·萨迪金医生总医院的所有脑出血患者的医疗记录。取病案记录的最小精神状态检查(MMSE)总分,采用Mann-Whitney检验进行组间比较。患者出院当天进行MMSE,最低文化程度为小学。结果:共发现109例脑出血患者,其中合并高血压危象者67例。高血压危象组的MMSE评分中位数略高于非高血压危象组。脑出血患者合并与不合并高血压危象的MMSE评分差异无统计学意义(p值=0.439)。结论:脑出血合并与不合并高血压危象的患者认知功能无明显差异。进一步探讨脑出血患者合并与不合并高血压危象的关系具有重要价值。
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Comparison of Cognitive Function between Intracerebral Haemorrhage Stroke Patients with and without Hypertensive Crisis
Background: Intracerebral haemorrhage (ICH) stroke is characterized by neurological dysfunction, caused by focal collection of blood within the brain parenchyma or ventricular system that is not caused by trauma. Hypertension is one of the main risk factors for intracerebral haemorrhage. Hypertensive crisis, which is a more severe type of uncontrolled hypertension may aggravate the cognitive outcomes. The aim of this study was to compare cognitive function between intracerebral haemorrhage stroke patients with and without hypertensive crisis. Methods: This study was a retrospective comparative analytic study, combined with a case-control study from August to November 2020. All medical records of patients with intracerebral haemorrhage, who were admitted to Dr. Hasan Sadikin General Hospital Bandung in 2019, were collected. The total score of mini-mental state examination (MMSE) which was recorded in the medical record was taken and compared between groups using the Mann-Whitney test. The MMSE was conducted on the day of discharge, and the minimum education level of the patients was elementary school. Results: We found a total of 109 medical records with ICH, 67 of which were with hypertensive crisis. The median MMSE score in the hypertensive crisis group was slightly higher than in the non-hypertensive crisis group. Furthermore, there was no statistical difference in MMSE scores between intracerebral haemorrhage patients with and without hypertensive crisis (p-value=0.439). Conclusion: There is no difference in cognitive function between intracerebral haemorrhage patients with and without hypertensive crisis. Further study is of great value to explore the relation between intracerebral haemorrhage patients with and without hypertensive crisis.
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