1,4 -苯并噻嗪合成的绿色途径:最新进展和展望

IF 0.9 Q4 CHEMISTRY, PHYSICAL Current Organocatalysis Pub Date : 2023-02-13 DOI:10.2174/2213337210666230213144211
B. Basu, Suchandra Bhattacharya
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引用次数: 1

摘要

杂环部分在自然界中无处不在,对杂环化学的探索可以追溯到几个世纪以前,这些探索已经结合在一起,发明了更环保的方法来合成具有潜在用途的杂环。苯并噻嗪是一类重要的杂环分子,其苯环与六元含氮、硫环融合。在三种可能的异构体中,1,4 -苯并噻唑类具有广泛的药物和生物活性,如抗炎、抗风湿、抗高血压和抗病原作用。为了寻找更环保的方案、无金属催化剂和环境友好的反应条件,到目前为止,已经有很多东西被打开了,还有许多其他方面仍有待破译。这篇小型综述试图根据反应组分和途径对过去十年中合成1,4 -苯并噻嗪支架的各种可持续方案进行分类,同时考虑到合理的机制见解和批判性分析。
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Greener Approaches towards 1,4–Benzothiazine Synthesis: Recent Updates and Outlook
Heterocyclic moieties are ubiquitous in nature and the exploration of heterocyclic chemistry goes centuries back , which have coalesced into the invention of greener methodologies towards the synthesis of heterocycles of potential uses. Benzothiazine is an important class of heterocyclic molecule, in which a benzene ring is fused with a six–member N, S containing ring. Amongst the three possible isomers, 1,4–benzothiazines show a wide spectrum of pharmaceutical and biological activities like anti–inflammatory, anti–rheumatic, antihypertensive, andantipathogenic roles. In search of greener protocols,metal–free catalysts, and environmentally benign reaction conditions, a lot have been unboxed to date, and many other dimensions remain yet to be deciphered. This minireview is an attempt to classify various sustainable protocols for the synthesis of 1,4–benzothiazine scaffolds over the last decade based on the reacting components and pathways, along with the consideration of plausible mechanistic insights and critical analysis.
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来源期刊
Current Organocatalysis
Current Organocatalysis CHEMISTRY, PHYSICAL-
CiteScore
2.00
自引率
0.00%
发文量
28
期刊介绍: Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.
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