肾Na-Cl共转运体对钙稳态和骨代谢的影响

Q4 Nursing 中华临床营养杂志 Pub Date : 2019-08-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2019.04.009

Bingbin Zhao, Lei Zhang

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引用次数: 0

摘要

骨质疏松症是一个全球性的公共卫生问题。肾脏尤其是位于肾远端小管细胞的Na-Cl共转运体(NCC)是尿钙调节的重要转运体，在钙稳态和骨代谢中起着重要作用。本文就NCC对钙和骨代谢的影响及其机制的研究进展作一综述。关键词:Na-Cl共转运体;钙稳态;骨代谢

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Effects of renal Na-Cl co-transporter on calcium homeostasis and bone metabolism

Osteoporosis is a global public health problem. The kidney, especially the Na-Cl co-transporter (NCC) located in the renal distal tubular cells, which is an important transporter for urinary calcium regulation, plays an important role in calcium homeostasis and bone metabolism. This review summarized recent researches on effects and mechanisms of NCC on calcium and bone metabolism. Key words: Na-Cl co-transporter; Calcium homeostasis; Bone metabolism

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.