Pratiksha Sonkusale, S. Kar, A. Deshmukh, Subhor Nandwani, Sangeeta Galui, Aditya Ambulkar
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They were subjected to careful history taking, dermatological and genital examination, assessment of FSH, LH, and testosterone levels, and slit skin smear for acid-fast bacilli. Diagnosis of leprosy was confirmed histopathologically. The collected data were encoded and entered electronically in a computer excel worksheet 2010 version. The statistical analysis was performed using SPSS version 17.0 for Windows. Pearson correlation coefficient was used to establish relationship between different variables. P ≤ 0.05 was considered statistically significant. Results: A positive correlation was found between FSH and LH hormones which was highly significant, whereas there was a negative correlation between testosterone and FSH and LH levels. There was a positive correlation between age, duration of disease, and reaction in leprosy with those of FSH and LH levels. There was a positive correlation between disease activity bacillary index (BI) and FSH, LH and a negative correlation between BI and testosterone. Conclusion: It is recommended that lepromatous leprosy patients should be routinely screened for hypogonadism using FSH, LH, and testosterone levels.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A pilot study on hypogonadism in male leprosy patients in rural tertiary care hospital in central India\",\"authors\":\"Pratiksha Sonkusale, S. Kar, A. Deshmukh, Subhor Nandwani, Sangeeta Galui, Aditya Ambulkar\",\"doi\":\"10.4103/mj.mj_35_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. Besides the skin and peripheral nerves, it also involves many internal organs. Testicular involvement is mainly seen in leprosy. Hypogonadism in males with leprosy can occur due the involvement of testis. Aim: The aim was to evaluate the gonadal function impairment in males with leprosy and to analyze the relation of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone to the activity, duration, and disease classification in Central India. Patients and Methods: This was a prospective observational pilot study. We evaluated 30 patients of leprosy. They were subjected to careful history taking, dermatological and genital examination, assessment of FSH, LH, and testosterone levels, and slit skin smear for acid-fast bacilli. Diagnosis of leprosy was confirmed histopathologically. The collected data were encoded and entered electronically in a computer excel worksheet 2010 version. The statistical analysis was performed using SPSS version 17.0 for Windows. Pearson correlation coefficient was used to establish relationship between different variables. P ≤ 0.05 was considered statistically significant. Results: A positive correlation was found between FSH and LH hormones which was highly significant, whereas there was a negative correlation between testosterone and FSH and LH levels. There was a positive correlation between age, duration of disease, and reaction in leprosy with those of FSH and LH levels. There was a positive correlation between disease activity bacillary index (BI) and FSH, LH and a negative correlation between BI and testosterone. 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引用次数: 0
摘要
背景:麻风是由麻风分枝杆菌引起的一种慢性肉芽肿性传染病。除了皮肤和周围神经外,它还涉及许多内脏器官。累及睾丸主要见于麻风病。男性麻风病患者的性腺功能减退可因睾丸受累而发生。目的:评价印度中部地区男性麻风患者的性腺功能损害,分析促卵泡激素(FSH)、黄体生成素(LH)和睾酮与麻风活动、病程和疾病分类的关系。患者和方法:这是一项前瞻性观察性初步研究。我们评估了30名麻风病患者。他们接受了详细的病史记录、皮肤和生殖器检查、FSH、LH和睾酮水平的评估以及抗酸杆菌的切开皮肤涂片检查。麻风病的诊断经病理组织学证实。收集到的数据被编码并以电子方式输入到计算机excel工作表2010版本中。采用SPSS 17.0 for Windows进行统计分析。采用Pearson相关系数建立不同变量之间的关系。P≤0.05认为有统计学意义。结果:FSH与LH呈显著正相关,而睾酮与FSH、LH呈显著负相关。年龄、病程、麻风病反应与FSH、LH水平呈正相关。疾病活动性杆菌指数(BI)与FSH、LH呈正相关,与睾酮呈负相关。结论:建议对麻风性麻风患者进行FSH、LH和睾酮水平的常规筛查,以检查其性腺功能减退。
A pilot study on hypogonadism in male leprosy patients in rural tertiary care hospital in central India
Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. Besides the skin and peripheral nerves, it also involves many internal organs. Testicular involvement is mainly seen in leprosy. Hypogonadism in males with leprosy can occur due the involvement of testis. Aim: The aim was to evaluate the gonadal function impairment in males with leprosy and to analyze the relation of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone to the activity, duration, and disease classification in Central India. Patients and Methods: This was a prospective observational pilot study. We evaluated 30 patients of leprosy. They were subjected to careful history taking, dermatological and genital examination, assessment of FSH, LH, and testosterone levels, and slit skin smear for acid-fast bacilli. Diagnosis of leprosy was confirmed histopathologically. The collected data were encoded and entered electronically in a computer excel worksheet 2010 version. The statistical analysis was performed using SPSS version 17.0 for Windows. Pearson correlation coefficient was used to establish relationship between different variables. P ≤ 0.05 was considered statistically significant. Results: A positive correlation was found between FSH and LH hormones which was highly significant, whereas there was a negative correlation between testosterone and FSH and LH levels. There was a positive correlation between age, duration of disease, and reaction in leprosy with those of FSH and LH levels. There was a positive correlation between disease activity bacillary index (BI) and FSH, LH and a negative correlation between BI and testosterone. Conclusion: It is recommended that lepromatous leprosy patients should be routinely screened for hypogonadism using FSH, LH, and testosterone levels.